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| 1 | Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells显示文摘AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. | Ho-Keun Kwon Ji-Sun Hwang Choong-Gu Lee Jae-Seon So Anupama Sahoo Chang-Rok Im Won Kyung Jeon Byoung Seob Ko Sung Haeng Lee Zee Yong Park Sin-Hyeog Im | 2011 | World Journal of Gastroenterology2011，17，8： | 6 |
| 2 | Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases显示文摘Objective: To investigate the important diagnostic indicators for blood stasis syndrome(BSS) in patients of childbearing age with gynaecological diseases. Methods: A partial least squared-discriminant analysis(PLS-DA) were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine(DKMs) among BSS patients with gynaecological diseases were also investigated. Results: A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63(61.7%) and 40(38.8%) were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion: DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases. | Jeeyoun Jung Mi Mi Ko Myeong Soo Lee So Min Lee Ju Ah Lee | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 3 |
| 3 | Induction of NG108-15 cell differentiation by human marrow stromal cells显示文摘 | Ho SH So LH Lai KO | 1998 | Neuroreport1998，9，： | 1 |
| 4 | TGF-131-induced epithelial-mesenchy- mal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in Human A549 lung cancer ceils 显示文摘 | Ko H So Y Jean H | 2013 | Cancer Letters2013，335，1： | 1 |
| 5 | Additive interaction of hyperglycemia and albuminuria on risk of ischemic stroke in type 2 diabetes 显示文摘 | Yang X Ko GT So WY | 2008 | Diabetes Care2008，31，： | 1 |
| 6 | Estrogen-recepter-related protein P29 in primary no-small cell lung carcinoma:pathologic and prognostic correlation显示文摘 | Vargas SO Leslie KO Vacek PM | 1998 | Cancer1998，82，8： | 1 |
| 7 | From design to implementation-theJoint Asia Diabetes Evaluation (JADE) program : a descriptive reportof an electronic web-based diabetes management program显示文摘 | Ko GT So WY Tong PQ | 2010 | BMCMed Inform Decis Mak2010，10，： | 1 |
| 8 | Totally laparoscopic total gastrectomy using intracorporeally hand-sewn esophagojejunostomy 显示文摘 | So KO Park JM | | J Gastric Cancer0，11，4： | 1 |
| 9 | Post partum haem- orrhage in a teaching hospital in Nigeria:a 5-year experi- ence显示文摘 | Ajenifuja KO Adepiti CA Ogunniyi SO | 2010 | Afr Health Sci2010，10，1： | 1 |
| 10 | Elevated serum level of interleukin-32alpha in the patients with myasthenia gravis 显示文摘 | Na SJ So SH Lee KO | 2011 | J Neurol2011，258，10： | 1 |
| 11 | A NASBA method to detect high-and low-pathogenicity H5 avian influenza viruses显示文摘 | Collins R A Ko L S So K L | 2003 | Avian Dis2003，47，3： | 1 |
| 12 | Prediction of cardiovascular and total mortality in Chinese type 2 diabetic patients by the WHO definition for the metabolic syndrome显示文摘 | Ko GTC So WY Chan NN | 2006 | Diabetes Obesity and Metabolism2006，，8： | 1 |
| 13 | Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes:the Hong Kong diabetes registry显示文摘 | Yang X Ko GT So WY | 2010 | Diabetes2010，59，5： | 1 |
| 14 | Detection of highly pathogenic and low pat hogenic avian influenza subtype H5(Eurasian lineage)using NASBA显示文摘 | Collins R A Ko L S So K L | 2002 | J Virol Methods2002，103，2： | 1 |
| 15 | A NASBA method to detect high-and low-pathogenicity H5 avian influenza viruses显示文摘 | Collins R A Ko L S So K L | 2003 | Avian Dis2003，，： | 1 |
| 16 | Totally laparoscopic total gastrectomy using intra- corporeally hand-sewn esophagojejunostomy显示文摘 | So KO Park JM | 2011 | J Gastric Cancer2011，11，4： | 1 |
| 17 | Factors affecting quality of life in Korean patients with chronic heart failure显示文摘 | Sang Hui CHU Won Hee LEE Ji Soo YOO So Sun KIM Il Sun KO Eui Geum OH JuHee LEE Mona CHOI Joo Young CHEON Chi Young SHIM Seok‐Min KANG | 2014 | Japan Journal of Nursing Science2014，，1： | 1 |
| 18 | Prediction of cardiovascular and total mortality in Chinese type 2 diabetic patients by the WHO definition for the metabolic syndrome 显示文摘 | Ko GTC So WY Chan NN | 2006 | Diabetes Obesity and Metabolism2006，8，： | 1 |
| 19 | Detection of highly pathogenic and low pathogenic avian influenza subtype H5(Eurasianlineage)using NASBA显示文摘 | COLLINS R A KO L S SO K L | | Journal of Virological Methods0，，： | 1 |
| 20 | TGF-131-inducedepithelial- mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cells显示文摘 | Ko H So Y Jeon H | 2013 | CancerLett2013，335，1： | 1 |
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