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| 1 | Platinum-induced neurotoxicity: A review of possible mechanisms显示文摘Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despitediscontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion(DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations. | Ozkan Kanat Hulya Ertas Burcu Caner | 2017 | World Journal of Clinical Oncology2017，8，4： | 14 |
| 2 | Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines显示文摘Objective: Oxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H 2 O 2 ) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP- 11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes. Methods: The mRNA transcripts in the cells were determined by RT-PCR. Following H 2 O 2 exposure, oxidative stress in the viable cells was analyzed by 2',7'-dichlorofluorescein diacetate (DCFH-DA). Caffeic acid phenethyl ester (CAPE) was used to eliminate oxidative stress and the consequence of H 2 O 2 exposure and its removal on the expressions of the genes were evaluated by quantitative real-time PCR. Results: The expressions of MMP-1, MMP-7, MMP-14, MMP-15, MMP-17 and β-catenin in MKN-45 cells and only the expression of MMP-15 in 23132/87 cells were increased. Removal of the oxidative stress resulted in decrease in the expressions of MMP genes of which the expressions were increased after H 2 O 2 exposure. β-catenin, a transcription factor for many genes including MMPs, also displayed decreased levels of expression in both of the cell lines following CAPE treatment. Conclusions: Our data suggest that there is a remarkable link between the accumulation of oxidative stress and the increased expressions of MMP genes in the gastric cancer cells and MMPs should be considered as potential targets of therapy in gastric cancers due to its continuous exposure to oxidative stress. | Salih Gencer Anil Cebeci Meliha Burcu Irmak-Yazicioglu | 2013 | Chinese Journal of Cancer Research2013，25，3： | 13 |
| 3 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic scores.METHODS:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy controls.The correlation between the clinical and histopathological features of NASH patients and RDW values was evaluated.Liver fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced fibrosis.RDW values were compared between NASH,simple steatosis and healthy controls.Univariate and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by NASH.RESULTS:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores. | Mustafa Cengiz Burcu Aslan Candir Güldal Yilmaz Gülen Akyol Seren Ozenirler | 2013 | World Journal of Gastroenterology2013，19，42： | 8 |
| 4 | Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis显示文摘Pancreatic metastases are uncommon. They have been reported in lung cancer, gastrointestinal malignancies, breast cancer, renal cell carcinoma, melanoma, lymphoma and sarcoma, and usually have solid morphology. Cystic metastasis to the pancreas is even more rare with few case reports in the literature. However, with the increasing use of computed tomography and magnetic resonance imaging as well as endoscopic ultrasound, more such lesions may be detected. Metastasis to the pancreas from osteosarcoma is highly unusual, but can be seen with the increasing survival of patients with osteosarcoma. We present an extremely rare case of a predominantly cystic lesion of the pancreas, which was diagnosed as metastasis from osteosarcoma. The pathophysiology of the cystic component of the metastasis of osteosarcoma is unknown. Cystic necrotic degeneration of the solid metastasis or pancreatitis secondary to the metastasis with development of associated fluid collection can be considered. Metastasis should remain a differential consideration even for primarily cystic lesions of the pancreas. | Burcu Akpinar Joshua Obuch Norio Fukami Sajal S Pokharel | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 5 | Midkine secretion protects Hep3B cells from cadmium induced cellular damage显示文摘AIM: To evaluate role of midkine secretion during Cadmium (Cd) exposure in the human hepatocyte cell line Hep3B cells. METHODS: Different dosages of Cd (0.5-1-5-10 μg/mL) were applied to Hep3B cells and their effects to apoptosis, lactate dehydrogenase (LDH) leakage and midkine secretion were evaluated as time dependent manner. Same experiments were repeated with exogenously applied midkine (250-5000 pg/mL) and/or 5 μg/mL Cd.RESULTS: Cd exposure induced prominent apoptosis and LDH leakage beginning from lower dosages at the 48th h. Cd induced midkine secretion with higher dosages (P < 0.001), (control, Cd 0.5-1-5-10 μg/mL respectively: 1123 ± 73, 1157 ± 63, 1242 ± 90, 1886 ± 175, 1712 ± 166 pg/mL). Exogenous 500-5000 pg/mL midkine application during 5 μg/mL Cd toxicity prevented caspase-3 activation (control, Cd toxicity, 250, 500, 1000, 2500, 5000 pg/mL midkine+ Cd toxicity, respectively: 374 ± 64, 1786 ± 156, 1545 ± 179, 1203 ± 113, 974 ± 116, 646 ± 56, 556 ± 63 cfu) LDH leakage and cell death in Hep3B cells (P < 0.001). CONCLUSION: Our results showed that midkine secretion from Hep3B cells during Cd exposure protects liver cells from Cd induced cellular damage. Midkine has anti-apoptotic and cytoprotective role during Cd toxicity. Further studies are needed to explain the mechanism of midkine secretion and cytoprotective role of midkine during Cd exposure. Midkine may be a promising theurapatic agent in different toxic hepatic diseases. | Nuray Yazihan Haluk Ataoglu Ethem Akcil Burcu Yener Bulent Salman Cengiz Aydin | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 6 | Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma显示文摘 | Burcu Gurer Giray Gurol Emekdas Seda Tezcan Mahmut Ulger Mehmet Sami Serin Orhan Sezgin Engin Altintas Eyup Naci Tiftik | 2014 | Molecular Biology Reports2014，，7： | 2 |
| 7 | Oxygen isotopic variations in modern cetacean teeth and bones: implications for ecological, paleoecological, and paleoclimatic studies显示文摘The oxygen isotope ratios(d18O) preserved in marine sediments have been widely used to reconstruct past ocean temperatures. However, there remain significant uncertainties associated with this method, owing to assumptions about the d18 O of ancient seawater which affects the temperature inferred from sediment d18 O records. In this study, oxygen isotope compositions of phosphate in teeth and bones from five different modern cetacean species, including sperm whale, pygmy sperm whale, short-finned pilot whale, killer whale, and Cuvier's beaked whale, and three fossil whales were determined. The data were used to assess whether the oxygen isotope ratios of biogenic phosphate(d18Op) from cetaceans are a reliable proxy for the oxygen isotopic composition of ocean water(d18Ow). The d18 Opvalues of modern cetaceans range from15.5 % to 21.3 %, averaging(19.6 %± 0.8 %)(n = 136).Using a greatly expanded global cetacean d18 Opdataset, the following regression equation is derived for cetaceans:d18Ow= 0.95317(±0.03293) d18Op- 17.971(±0.605),r = 0.97253. The new equation, when applied to fossil teeth and bones, yielded reasonable estimates of ancient seawater d18 Owvalues. Intra-tooth isotopic variations were observed within individual teeth. Among the selected species, the killer whale(O. orca) has the lowest d18 Opvalues and the largest intra-tooth d18 Opvariation, reflecting its habitat preference and migratory behavior. The results show that oxygen isotope analysis of phosphate in cetacean teeth and dense ear bones provides a useful tool for reconstructing the oxygen isotopic composition of seawater and for examining environmental preferences(including migratory behavior)of both modern and ancient whales. | Burcu Ciner Yang Wang William Parker | 2016 | Science Bulletin2016，61，1： | 2 |
| 8 | 玻璃体内注射贝伐单抗对DME患者视力、黄斑中心厚度和眼血流的影响(英文)显示文摘目的:探讨玻璃体内注射贝伐单抗对伴有黄斑水肿的糖尿病患者眼血流参数的影响。方法:患者21例21眼,伴有弥漫性糖尿病性黄斑水肿(diabeticmacular edema,DME),黄斑中心厚度(central macularthickness,CMT)>320μm,无缺血性黄斑水肿或其他血管性视网膜疾病。患者术前以及注射1.25mg/0.05mL贝伐单抗1d,4wk后接受三种眼科检查:视力(visual acuity,VA)检测、光学相干断层扫描(optical coherence tomography,OCT)测量CMT以及采用超声成像测量眼动脉(ophthalmicartery,OA)、视网膜中央动脉(central retinal artery,CRA)、鼻侧睫状后动脉(nasal posterior ciliary artery,NPCA)以及颞侧睫状后动脉(temporal posterior ciliary artery,TPCA)中的收缩期峰值血流速度(peak systolic velocities,PSV)和舒张末期血流速度(end-diastolic velocities,EDV)。阻力指数(resistive indices,RI)由软件自动计算,注射前与注射后1d的血流速度进行了比较。患者术前和注射后4wk的VA和CMT值进行了比较。结果:注射前平均最佳矫正视力(best-corrected visual acuity,BCVA)为0.88±0.21logMAR,注射后为0.54±0.19logMAR(P<0.01)。平均CMT由注射前440.57±54.58μm下降至250.33±31.12μm(-190.24±36.00μm)。PSV、EDV和RI的变化并不显著。结论:贝伐单抗注射后视力显着改善,CMT降低,而PSV、EDV和RI在OA、CRA、TPCA和NPCA中没有显著变化。玻璃体内注射贝伐单抗注射液能改善VA和CMT,但对于糖尿病患者的OA、CRA、TPCA和NPCA的血流速度没有影响。 | Mehmet Demir Alper Ozel Burcu Dirim Erhan Ozdal Efe Can | 2013 | 国际眼科杂志2013，13，3： | 2 |
| 9 | Development of Chromium(Ⅲ)-selective Potentiometric Sensor by Using Synthesized Pyrazole Derivative as an lonophore in PVC Matrix and its Applications显示文摘A novel poly(vinyl chloride)membrane potentiometric sensor for chromium(Ⅲ)ions based on the use of 5,5′-(1,4-phenylene)bis(3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide)as a neutral ionophore was developed.The optimum composition of the best performing membrane contained ionophore,potassium tetrakis(p-chlorophenyl)borate(KTpClPB),dibutyl phthalate(DBP),and poly(vinyl chloride)(PVC)in the ratio of 5.5:1.5:55:38(mg).The sensor exhibits a working concentration range of 1.0×10^(-5)-1.0×10^(-1 )mol L^(−1) and a detection limit of 1.7×10^(-6) mol L^(−1).The sensor shows good selectivity for chromium(III)ions over a number of cations including alkali,alkaline earth,heavy and transition metals.The response time of the sensor is 8 s.In addition,the developed sensor shows good reusability and stability.The sensor operates in the wide pH range of 5.0-11.0.The sensor could be used as an indicator electrode in the quantification of Cr^(3+)ions by potentiometric titration against ethylenediaminetetraacetic acid(EDTA).Finally,this sensor was successfully used for the determination of chromium(III)in commercial water,purification water and wastewater. | Ömer Isildak OguzÖzbek Meliha Burcu Gürdere | 2020 | Journal of Analysis and Testing2020，4，4： | 2 |
| 10 | Dexmedetomidine Infusion During Laparoscopic Bariatric Surgery: The Effect on Recovery Outcome Variables显示文摘 | Burcu Tufanogullari Paul F. White Mariana P. Peixoto Daniel Kianpour Thomas Lacour James Griffin Gary Skrivanek Amy Macaluso Mary Shah David A. Provost | 2008 | Anesthesia & Analgesia2008，，6： | 2 |
| 11 | Evaluation of the relationship between heart type fatty acid binding protein levels and the risk of cardiac damage in patients with obstructive sleep apnea syndrome显示文摘 | Burcu O Erdem A Hikmet F | 2008 | Sleep Breath2008，12，3： | 1 |
| 12 | Steam pyrolysis of an industrial waste for bio-oil production显示文摘 | Eylemp Onal Basak Burcu Uzum Ayse Putun | | 0，，： | 1 |
| 13 | Applied Catalysis A: General 显示文摘 | Burcu Mirkelamoglu Gurkan Karakas | 2005 | 281 : 275 - 2842005，281，： | 1 |
| 14 | Discharge formula for rectangular sharp-crested weirs 显示文摘 | Ismail Aydin A Burcu Altan-Sakarya Cigdem Sisman | 2011 | Flow Measurement and Instrumentation2011，22，： | 1 |
| 15 | Effects of nitric oxide synthase inhibition on spatial discrimination learning and central DA2 and mACh receptors显示文摘 | Ersin O. Koylu Lutfiye Kanit Dilek Taskiran Taner Dagci Burcu Balkan Sakire Pogun | 2005 | Pharmacology, Biochemistry and Behavior2005，，1： | 1 |
| 16 | Spectrophotometric determination of ascorbic acid by the modified CUPRAC method with extractive separation of flavonoids-La(III) complexes显示文摘 | Mustafa Ozy ii rek Kubilay G ti 1 fi Burcu Bekta$olu | 2007 | Analytica Chimica Acta2007，588，1： | 1 |
| 17 | Co -localization of cart peptide immunoreactivity and nitric oxide synthase activity in rat hypothalamus显示文摘 | Ersin OK Eduardo W Burcu B | 2000 | Brain Res2000，868，： | 1 |
| 18 | Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans 显示文摘 | Kielstein JT Burcu I Solveig S | 2004 | Circulation2004，109，2： | 1 |
| 19 | Impact of obstetrical brachial plexus injury on parents显示文摘 | Tüzün F Deran O Burcu SA | 2012 | Pediatrics International2012，54，6： | 1 |
| 20 | Determination of oxidative stress in thyroid tissue and plasma of patients with Graves’ disease显示文摘 | Evin Ademo?lu Ne?e ?zbey Ye?im Erbil Sevda Tanrikulu Umut Barbaros Burcu Tulumo?lu Yanik Alp Bozbora Sel?uk ?zarma?an | 2006 | European Journal of Internal Medicine2006，，8： | 1 |
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