|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 3 | Endovascular treatment of descending aortic dissection (type B): short- and mediumterm results显示文摘 | Flecher E Cluzel P Bonnet N | 2008 | Arch Cardiovas Dise2008，101，： | 1 |
| 4 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietie cell显示文摘 | Bonnet D Dick I E | 1997 | N atureM ed1997，3，7： | 1 |
| 5 | Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-eell activation in HIV-exposed uninfected individuals 显示文摘 | Ravet S Scott-Atgara D Bonnet E | 2007 | Blood2007，109，10： | 1 |
| 6 | Effects of Light, Oxygen and Concentration on Vitamin A1 显示文摘 | FAILLOUX N BONNET I PERRIER E | 2004 | Journal of Raman Spectroscopy2004，35，2： | 1 |
| 7 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell 显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
| 8 | Left atrial appendage morphology: comparison of transesophageal images and postmortem casts显示文摘 | Stollberger C Ernst G Bonnet E | 2003 | Z Kardiol2003，92，： | 1 |
| 9 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell 显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
| 10 | Isolation of the DNA of various plant pathogenic mycoplasmalike organisms from infeeted plants 显示文摘 | Kollar A Seemuller E Bonnet F | 1990 | Phytopathology1990，80，3： | 1 |
| 11 | Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries显示文摘 | Bonnet M Sizaire V Kebede Y Janin A Doshetov D Mirzoian B Arzumanian A Muminov T Iona E Rigouts L Rusch-Gerdes S Varaine F | 2005 | Int J Tuberc Lung Dis2005，9，10： | 1 |
| 12 | Marker-assisted selection for the wide-spectrum resistance to root-knot nematodes conferred by the Ma gene from Myrobalan plum(Prunus cerasifera)in interspecific Prunus material显示文摘 | LECOULS A C BERGOUGNOUX V RUBIO-CABETAS M J BOSSELUTN VOISIN R POESSEL J L FAUROBERTM BONNET A SALESSES G DIRLEWANGER E ESMENJAUD D | 2004 | Molecular Breeding2004，13，： | 1 |
| 13 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
| 14 | A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis显示文摘 | Somm E Bonnet N Martinez A | 2012 | J Clin Invest2012，122，9： | 1 |
| 15 | Effects of ac- etaminophen on morphine side-effects and consump- tion after major surgery: Meta-analysis of randomized controlled trials显示文摘 | Remy C Marret E Bonnet F | 2005 | Br J Anaesth2005，94，4： | 1 |
| 16 | An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension显示文摘 | Sébastien Bonnet Evangelos D. Michelakis Christopher J. Porter Miguel A. Andrade-Navarro Bernard Thébaud Sandra Bonnet Alois Haromy Gwyneth Harry Rohit Moudgil M Sean McMurtry E Kenneth Weir Stephen L. Archer | 2006 | Circulation2006，，22： | 1 |
| 17 | An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats:similarities to human pulmonary arterial hypertension显示文摘 | BONNET S MICHELAKIS E D PORTER C J | 2006 | Circulation2006，11，22： | 1 |
| 18 | Alternating combination chemotherapy and levamisole improves survival in multiple myeloma: a Southweste Oncology Group Study显示文摘 | Salmon S E Haut A Bonnet J D | 1983 | J Clin Onco1983，1，： | 1 |
| 19 | Human acute myeloid leukemia is organized as a hierarchy that origination from a primitive hematopoietic cell显示文摘 | Bonnet D Dick I E | 1997 | Nature Med1997，3，7： | 1 |
| 20 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell 显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员