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| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 3 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 4 | A reciprocal translocation between ’Garfi’ almond and ’Nemared’ peach显示文摘 | B. Jáuregui M.C. de Vicente R. Messeguer A. Felipe A. Bonnet G. Salesses P. Arús | 2001 | TAG Theoretical and Applied Genetics2001，，8： | 2 |
| 5 | Effect of high ambient temperature on feed digestibility in broilers显示文摘 | Bonnet S Geraert P A Lessire M | 1997 | Poultry Science1997，76，： | 1 |
| 6 | Post-antibiotic and post-β-lactamase inhibitor effects of ceftazidime plus sulbac- tam on extended-spectrum β-lactamase-producing Gram-negative bacteria 显示文摘 | Lavigne JP Bonnet R Miehaux-Charachon S | 2004 | J Antimicrob Chemother2004，53，4： | 1 |
| 7 | Role of Ca^2+-sensitive K+ channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases显示文摘 | Bonnet S Savineau JP Barillot W | 2003 | Cardiovasc Res2003，60，： | 1 |
| 8 | Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-eell activation in HIV-exposed uninfected individuals 显示文摘 | Ravet S Scott-Atgara D Bonnet E | 2007 | Blood2007，109，10： | 1 |
| 9 | Dynamic X-ray computed tomography显示文摘 | Bonnet S Koenig A | 2003 | Proceeding of the IEEE2003，91，10： | 1 |
| 10 | The food-contaminant deoxynivalcnol modifies eating by targeting anorexigenic neurocircuitry 显示文摘 | Girarcdt C Bonnet M S Jdir R | 2011 | PLOS ONE2011，6，26： | 1 |
| 11 | Tuberculosis treatment in a refugee and migrant population: 20years of experience on the Thai-Burmese border显示文摘 | Minetti A Camelique O Hsa Thaw K Thi S Swaddiw-udhipong W Hewison C Pinoges L Bonnet M Guerin PJ | 2010 | Int J Tu- berc Lung Dis2010，14，12： | 1 |
| 12 | Upregulation of L-type Ca^2+ channels in mesenteric and skeletal arteries of SHR显示文摘 | Pratt PF Bonnet S Ludwig LM | 2002 | Hypertension2002，40，： | 1 |
| 13 | Influence of Traversing Crack on Chloride Diffusion into Con- crete 显示文摘 | DJERBI A BONNET S KHELIDJ A | 2008 | Cement and Concrete Research2008，38，6： | 1 |
| 14 | Development of a new ELISA for serum periostin:evaluation of growth-related changes and bisphospho- nate treatment in mice显示文摘 | Conti6 S Voorzanger-Rousselot N Litvin J Bonnet N Ferrari S Clezardin P | 2010 | Calcif Tissue Int2010，87，： | 1 |
| 15 | Efficiency of semi-automated fluorescent multiplex PCRs with 11 microsatellite markers for genetic studies of deer populations 显示文摘 | Bonnet A Thevenon S Maudet F | 2002 | Animal Genetics2002，33，5： | 1 |
| 16 | Prophylactic lymph node dissection for papillary thyroid cancer less than 2 cm: im- plications for radioiodine treatment 显示文摘 | Bonnet S Hartl D Leboulleux S | 2009 | J Clin Endoerinol Metab2009，94，11： | 1 |
| 17 | DNA-magnetite nanocomposite materials 显示文摘 | Mornet S Vekris A Bonnet J | 2000 | Mater Lett2000，42，3： | 1 |
| 18 | Mechanical Characterization of Cement-based Mortar Incorporating Rubber Aggregates from Recycled Worn Tyres显示文摘 | TURATSINZE A BONNET S GRANJU J | 2005 | Building and Environment2005，40，2： | 1 |
| 19 | Evaluation of thick organiccoatings degradation in seawater using cathodic protection and thermally accelerated tests 显示文摘 | Touzain S Le Thu Q Bonnet G | 2005 | Progress in Organic Coatings2005，52，4： | 1 |
| 20 | Dichloroacetate pre vents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis显示文摘 | Mc Murtry MS Bonnet S Wu X | 2004 | Circ Res2004，95，8： | 1 |
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