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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Isolation and Expression Analysis of Two Genes Encoding Cinnamate 4-Hydroxylase from Cotton(Gossypium hirsutum)显示文摘Two genes(GhC4H1 and GhC4H2) that encode putative cotton cinnamate 4-hydroxylases that catalyze the second step in the phenylpropanoid pathway were isolated from developing cotton fibers. GhC4H1 and GhC4H2 each contain open reading frames of 1 518 base pairs(bp) in length and both encode proteins consisting of 505 amino acid residues. They are 90.89% identical to each other at the amino acid sequence level and belong to class I of plant C4 Hs. GhC4H1 and GhC4H2 genomic DNA are 2 247 and 2 161 bp long, respectively, and contain two introns located at conserved positions relative to the coding sequence. GhC4H1 and GhC4H2 promoters were isolated and found to contain many cis-elements(boxes P, L and AC-I element) previously identified in the promoters of other phenylpropanoid pathway genes. Histochemical staining showed GUS expression driven by the GhC4H1 and GhC4H2 promoters in ovules and fibers tissues. GhC4H1 and GhC4H2 were also widely expressed in other cotton tissues. GhC4H2 expression reached its highest level during the elongation stage of fiber development, whereas GhC4H1 expression increased during the secondary wall development period in cotton fibers. Our results contribute to a better understanding of the biochemical role of GhC4H1 and GhC4H2 in cotton fiber development. | NI Zhi-yong LI Bo Neumann M Peter Lü Meng FAN Ling | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | A chemical method to graft carbon nanotubes onto a carbon fiber显示文摘 | Abdelghani Laachachi Alexandre Vivet Gérard Nouet Bessem Ben Doudou Christophe Poilane Jun Chen Jin Bo bai M’Hamed Ayachi | 2007 | Materials Letters2007，，3： | 3 |
| 5 | Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist显示文摘 | Sama I. Sayin Annika Wahlstr?m Jenny Felin Sirkku J?ntti Hanns-Ulrich Marschall Krister Bamberg Bo Angelin Tuulia Hy?tyl?inen Matej Ore?i? Fredrik B?ckhed | 2013 | Cell Metabolism2013，，2： | 3 |
| 6 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 7 | Cardiac implications of thrombotic thrombocytopenic purpura显示文摘Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular thrombosis.Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac involvement would also benefit from routine cardiology follow up during remission. | Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai | 2018 | World Journal of Cardiology2018，10，12： | 2 |
| 8 | Error analysis for four-axis side milling of undevelopable ruled surfaces 显示文摘 | Yang Bo Leu M C Zhou Ji | 1998 | Control Engineering Practice1998，6，4： | 2 |
| 9 | Defining strawberry shape uniformity using 3D imaging and genetic mapping显示文摘Strawberry shape uniformity is a complex trait,influenced by multiple genetic and environmental components.To complicate matters further,the phenotypic assessment of strawberry uniformity is confounded by the difficulty of quantifying geometric parameters‘by eye’and variation between assessors.An in-depth genetic analysis of strawberry uniformity has not been undertaken to date,due to the lack of accurate and objective data.Nonetheless,uniformity remains one of the most important fruit quality selection criteria for the development of a new variety.In this study,a 3D-imaging approach was developed to characterise berry shape uniformity.We show that circularity of the maximum circumference had the closest predictive relationship with the manual uniformity score.Combining five or six automated metrics provided the best predictive model,indicating that human assessment of uniformity is highly complex.Furthermore,visual assessment of strawberry fruit quality in a multi-parental QTL mapping population has allowed the identification of genetic components controlling uniformity.A“regular shape”QTL was identified and found to be associated with three uniformity metrics.The QTL was present across a wide array of germplasm,indicating a potential candidate for marker-assisted breeding,while the potential to implement genomic selection is explored.A greater understanding of berry uniformity has been achieved through the study of the relative impact of automated metrics on human perceived uniformity.Furthermore,the comprehensive definition of strawberry shape uniformity using 3D imaging tools has allowed precision phenotyping,which has improved the accuracy of trait quantification and unlocked the ability to accurately select for uniform berries. | Bo Li Helen M.Cockerton Abigail WJohnson Amanda Karlström Eleftheria Stavridou Greg Deakin Richard J.Harrison | 2020 | Horticulture Research2020，7，1： | 2 |
| 10 | Information Acquisition in desert ant navigation显示文摘 | Gao J Wang L Bo M | 2006 | International Joumal of Information Acquisi-tion2006，3，01： | 1 |
| 11 | Simultaneous determination of ammonia,dimethylamine,trimethylamine and trimethylamine-N -oxide in fish extracts by capillary electrophoresis with indirect UV-detection显示文摘 | Timm Maike Jorgensen Bo M | 2002 | Food Chem2002，76，： | 1 |
| 12 | A review of the treatm ent of chronic hepatitis C virus infection in cirrhosis显示文摘 | Vezali E Aghem o A Colom bo M | 2010 | Clin Ther2010，32，13： | 1 |
| 13 | The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures 显示文摘 | Bo Bai Laith M J Frederick JK | 1999 | Spine1999，24，： | 1 |
| 14 | Diffusion- weighted magnetic resonance imaging for the assessment of fi- brosis in chronic hepatitis C 显示文摘 | Lewin M Poujol-Robert A Bo lie PY | 2007 | Hepatology2007，46，： | 1 |
| 15 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials显示文摘 | Peter M Rothwell Michelle Wilson Carl-Eric Elwin Bo Norrving Ale Algra Charles P Warlow Tom W Meade | 2010 | 2010 (9754)2010，，9754： | 1 |
| 16 | Biogeochemistry of sulfur and iron in Thioploca-colonized surface sediments in the upwelling area off central chile显示文摘 | Zopfi J Bottcher M E Jorgensen Bo B | 2008 | Geochimica et Cosmochimica Acta2008，72，： | 1 |
| 17 | Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line显示文摘 | Mancini M Anderson BO Caldwell E | 1997 | J Cell Biol1997，138，2： | 1 |
| 18 | Effects of D-cycloserine on extinction: translationfrom preclinical to clinical work 显示文摘 | Davis M Ressler K Rothbaum BO | 2006 | Biol Psychiatry2006，60，4： | 1 |
| 19 | Structure and digestibility of endosperm water-soluble a-glucans from different sugary maize mutants 显示文摘 | MING M RONG L BO J | 2014 | Food Chemistry2014，143，143： | 1 |
| 20 | Genetic background of patients from a university medical center in Manhattan : implications for personalized medicine显示文摘 | Tayo BO Teil M Tong L | 2011 | PLoS One2011，6，19： | 1 |
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