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| 1 | Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma显示文摘瞄准:估计是否 transarterial chemoembolization 的联合的有效性(不作声) 并且在 unresectable 肝细胞癌(HCC ) 的治疗的经皮的乙醇注射(PEI ) 是优异的独自不作声使随机化的控制试用是 performed.METHODS:长期的幸存率和住院的持续时间上的联合治疗的效果在 52 以前未经治疗的 HCC 被评估,随机分配了到 TACE-PEI (27 磅) 或独自不作声(25 磅) 。结果:TACE 组的累积幸存率在 6 瞬间是 75.8% , 62.9% 在 12 瞬间,并且 18.0% 分别地在 24 瞬间并且 TACE-PEI 组织 76.9% , 61.5% ,和 38.7% 。在两个组的全面幸存的比较统计上不出现了有效差量。关于有 HCC 的病人, Okuda 上演我(n = 26 ) , TACE-PEI 组的中部的幸存显著地更长(>24 瞬间,还没在学习时期到达的 median ) 与 TACE 组相比(18.4 瞬间[范围 11.6-21.7 瞬间] ;P = 0.04 ) 。TACE-PEI 为死亡把相对风险归结为 0.4 (95%CI 0.15-0.96 ) 独自与接待了的病人相比不作声。在有 HCC Okuda 阶段 II 或 III 的病人的中部的幸存是在 TACE 组的 5.0 瞬间(1.7 瞬间不定义) 与 10.4 相比,在 TACE-PEI 的瞬间组织。结论:联合 TACE-PEI 改进了生存时间与相比独自不作声。我们的学习在 HCC Okuda 舞台揭示了统计上重要的改进幸存我。副作用是次要的,联合治疗没更加延长住院的持续时间。 | Gerhild Becker Tarik Soezgen Manfred Olschewski Joerg Laubenberger Hubert Erich Blum Hans-Peter Allgaier | 2005 | World Journal of Gastroenterology2005，11，39： | 32 |
| 2 | Hepatocellular carcinoma: Therapy and prevention显示文摘Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The major etiologies and risk factors for the development of HCC are well defined and some of the multiple steps involved in hepatocarcinogenesis have been elucidated in recent years. Despite these scientific advances and the implementation of measures for the early detection of HCC in patients at risk, patient survival has not improved during the last three decades. This is due to the advanced stage of the disease at the time of clinical presentation and limited therapeutic options. The therapeutic options fall into five main categories: surgical interventions including tumor resection and liver transplantation, percutaneous interventions including ethanol injection and radiofrequency thermal ablation, transarterial interventions including embolization and chemoembolization, radiation therapy and drugs as well as gene and immune therapies. These therapeutic strategies have been evaluated in part in randomized controlled clinical trials that are the basis for therapeutic recommendations. Though surgery, percutaneous and transarterial interventions are effective in patients with limited disease (1-3 lesions, <5 cm in diameter) and compensated underlying liver disease (cirrhosis Child A), at the time of diagnosis more than 80% patients present with multicentric HCC and advanced liver disease or comorbidities that restrict the therapeutic measures to best supportive care. In order to reduce the morbidity and mortality of HCC, early diagnosis and the development of novel systemic therapies for advanced disease, including drugs, gene and immune therapies as well as primary HCC prevention are of paramount importance. Furthermore, secondary HCC prevention after successful therapeutic interventions needs to be improved in order to make an impact on the survival of patients with HCC. New technologies, including gene expression profiling and proteomic analyses, should allow to further elucidate the molecular events underlying HCC development and to identify novel diagnostic markers as well as therapeutic and preventive targets. | Hubert E Blum | 2005 | World Journal of Gastroenterology2005，11，47： | 27 |
| 3 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 4 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 5 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 6 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 7 | Hepatitis C virus infection and apoptosis显示文摘Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis and upregulation of the death inducing ligands CD95/Fas, TRAIL and TNFα occur. Nevertheless, HCV infection persists in the majority of patients. The impact of apoptosis in chronic HCV infection is not well understood. It may be harmful by triggering liver fibrosis, or essential in interferon (IFN) induced HCV elimination. For virtually all HCV proteins, pro- and anti-apoptotic effects have been described, especially for the core and NS5A protein. To date, it is not known which HCV protein affects apoptosis in vivo and whether the infectious virions act pro- or anti- apoptotic. With the availability of an infectious tissue culture system, we now can address pathophysiologically relevant issues. This review focuses on the effect of HCV infection and different HCV proteins on apoptosis and of the corresponding signaling cascades. | Richard Fischer Thomas Baumert Hubert E Blum | 2007 | World Journal of Gastroenterology2007，13，36： | 10 |
| 8 | 干旱胁迫条件下不同基因型小麦品种的冠层温度和产量稳定性显示文摘在干旱胁迫下,利用冠层温度作为抗旱指标,寻求不同水分状态条件下不同基因型间冠层温度和产量稳定性的关系。于1986—1987和1987—1988年度分别试验了68个普通小麦和17个硬粒小麦品种,供试品种都生长在防雨棚内,或作充分灌溉处理或作逐渐增强的水分胁迫处理。各品种的籽粒产量稳定性由“干旱敏感指数”估计,即由胁迫和非胁迫环境下产量的差值来估计。冠层温度指示每种基因型植株的相对水分胁迫,比较“干早敏感指数”与干早胁迫下正午时的冠层温度,发现在两年里,对于不同基因型,二首呈正相关。这表明在于早胁迫下“干旱敏感”的品种不仅产量遭受损失较大,而且植株常处于较大的水分胁迫下,正午时的冠层温度也较高。以上结果有助于在干旱胁迫下,采用两种差异显著的水分状况,估计产量稳定性(或“干旱敏感指数”),同时可以应用冠层温度,作为选择抗旱性的手段。 | A. Blum 张转放 武卷丽 | 1991 | 国外农学(麦类作物)1991，，2： | 10 |
| 9 | Medical management of gastric cancer:A 2014 update显示文摘Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy(United States),pre-and post-operative chemotherapy(Europe),and adjuvant chemotherapy after a D2 resection(Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population,the treatments remain limited.In the first line setting,the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy,with or without epirubicin or docetaxel.The results of targeted therapy trials have by and large been disappointing,but none of these trials looked at an appropriately enriched population.Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting,with either irinotecan,docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial. | Elena Elimova Hironori Shiozaki Roopma Wadhwa Kazuki Sudo Qiongrong Chen Jeannelyn S Estrella Mariela A Blum Brian Badgwell Prajnan Das Shumei Song Jaffer A Ajani | 2014 | World Journal of Gastroenterology2014，20，38： | 10 |
| 10 | ⑥无反作用力的摇振器—DuoShake显示文摘 | Walter Blum | 2004 | 中华纸业2004，25，9： | 4 |
| 11 | Umbilical hernia in patients with liver cirrhosis: A surgical challenge显示文摘Umbilical hernia occurs in 20% of the patients with liver cirrhosis complicated with ascites. Due to the enormous intraabdominal pressure secondary to the ascites, umbilical hernia in these patients has a tendency to enlarge rapidly and to complicate. The treatment of umbilical hernia in these patients is a surgical challenge. Ascites control is the mainstay to reduce hernia recurrence and postoperative complications, such as wound infection, evisceration, ascites drainage, and peritonitis. Intermittent paracentesis, temporary peritoneal dialysis catheter or transjugular intrahepatic portosystemic shunt may be necessary to control ascites. Hernia repair is indicated in patients in whom medical treatment is effective in controlling ascites. Patients who have a good perspective to be transplanted within 3-6 mo, herniorrhaphy should be performed during transplantation. Hernia repair with mesh is associated with lower recurrence rate, but with higher surgical site infection when compared to hernia correction with conventional fascial suture. There is no consensus on the best abdominal wall layer in which the mesh should be placed: Onlay, sublay, or underlay. Many studies have demonstrated several advantages of the laparoscopic umbilical herniorrhaphy in cirrhotic patients compared with open surgical treatment. | Julio CU Coelho Christiano MP Claus Antonio CL Campos Marco AR Costa Caroline Blum | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 4 |
| 12 | Flammability standards for furniture,building insulation and electronics:Benefit and risk显示文摘Flammability standards for furniture,building insulation and electronics were established in an attempt to mitigate fire risk.However,research suggests that some of these flammability standards should be reconsidered.High levels of flame retardant chemicals,primarily organohalogens,are added to these products in order to comply with fire safety standards.Organohalogen and organophosphate flame retardants are associated with adverse health effects such as diminished immune function,endocrine disruption,and cancer.Further,flame retardants may not provide a significant fire safety benefit as used in many products,and these chemicals can hinder material recycling.We reviewed evidence of how flammability standards drive the continued use of harmful flame retardants and investigated cases in which flame retardants are used to achieve standard compliance without providing a significant fire safety benefit.The widespread continuous use of toxic flame retardant chemicals demonstrates that toxicological evidence and chemical-by-chemical regulation alone are not sufficient to prevent their inclusion in consumer products.However,recent experiences show that updated flammability standards can reduce the use of flame retardants while maintaining,or even increasing,fire safety.Additional opportunities exist for improved standards that could further decrease flame retardant use and maintain fire safety. | Joseph A.Charbonnet Roland Weber Arlene Blum | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 13 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil2007，，1： | 2 |
| 14 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 15 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Neil J. Stone Jennifer G. Robinson Alice H. Lichtenstein C. Noel Bairey Merz Conrad B. Blum Robert H. Eckel Anne C. Goldberg David Gordon Daniel Levy Donald M. Lloyd-Jones Patrick McBride J. Sanford Schwartz Susan T. Shero Sidney C. Smith Karol Watson Pet | 2014 | Circulation (_suppl_ Suppl)2014，，25： | 2 |
| 16 | Categorization of multiscale-decomposition-based image fusion schemes with a performance study for a digital camera application显示文摘 | Zhong Zhang Blum R S A | 1999 | Proceedings of the IEEE1999，87，8： | 2 |
| 17 | Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma显示文摘 | Tobias Flecken Nathalie Schmidt Sandra Hild Emma Gostick Oliver Drognitz Robert Zeiser Peter Schemmer Helge Bruns Thomas Eiermann David A. Price Hubert E. Blum Christoph Neumann‐Haefelin Robert Thimme | 2014 | Hepatology2014，，： | 2 |
| 18 | Insulin- like growth factor I in neonatal calves fed colostrums or whole milk and injected with growth hormone显示文摘 | GRUETTER BLUM | 1991 | J Anim Physiol Nutr1991，66，： | 2 |
| 19 | 工作轧辊轴承的较长使用寿命显示文摘 | Blum,J 刘家文 | 1996 | 国外轴承技术1996，，2： | 2 |
| 20 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil (-)2007，，1： | 2 |
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