|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 2 | Effect of methoxychlor on antioxidant system of goat epididymal sperm in vitro显示文摘Aim: To evaluate the effect of methoxychlor on the antioxidant system of goat epididymal sperm. Methods:Epididymis of adult goat was obtained from local slaughter houses and sperm were collected by chopping the epididymis in modified Ringer's phosphate solution (RPS). After several washings, the sperm samples were dispersed in RPS and incubated with methoxychlor (1 μnol/L, 10 μmol/L and 100 μmol/L) and methoxychlor + vitamin C (100μmol/L each) for 3 h at 32℃. After incubation, the sperm motility and viability were assessed. An aliquot of sperm sample was homogenized, centrifuged and used for the assay of superoxide dismutase, glutathione peroxidase, glutathione reductase and lipid peroxidation. Results: In methoxychlor-incubated sperm and in sperm co-incubated with methoxychlor and vitamin C, the sperm motility and viability showed no significant changes as compared to the corresponding controls. In methoxychlor-incubated sperm the activity of superoxide dismutase, glutathione reductase and glutathione peroxidase were decreased while lipid peroxidation was increased in a dose-dependent manner. Co-incubation of sperm with methoxychlor and vitamin C showed no changes in the activity of superoxide dismutase, glutathione reductase and glutathione peroxidase and in the level of lipid peroxidation. Conclusion: Methoxychlor induced oxidative stress in epididymal sperm of goats by decreasing the levels of antioxidant enzymes. Co-incubation of sperm with methoxychlor and vitamin C, a natural antioxidant, reversed the effect of methoxychlor. | Bindu Gangadharan M.Arul Murugan P.P.Mathur | 2001 | Asian Journal of Andrology2001，3，4： | 13 |
| 3 | Initiation of Parkinson’s disease from gut to brain byδ-secretase显示文摘Lewy pathology,composed ofα-Synuclein(α-Syn)inclusions,a hallmark of Parkinson’s disease(PD),progressively spreads from the enteric nervous system(ENS)to the central nervous system(CNS).However,it remains unclear how this process is regulated at a molecular level.Here we show thatδ-secretase(asparagine endopeptidase,AEP)cleaves bothα-Syn at N103 and Tau at N368,and mediates their fibrillization and retrograde propagation from the gut to the brain,triggering nigra dopaminergic neuronal loss associated with Lewy bodies and motor dysfunction.α-Syn N103 and Tau N368 robustly interact with each other and are highly elevated in PD patients’gut and brain.Chronic oral administration of the neurotoxin rotenone induces AEP activation andα-Syn N103/Tau N368 complex formation in the gut,eliciting constipation and dopaminergic neuronal death in an AEP-dependent manner.Preformed fibrils(PFFs)ofα-Syn N103/Tau N368 are more neurotoxic and compact,and aggregate more quickly along the vagus nerve than their FL/FL counterparts or the individual fragments’fibrils.Colonic injection of PFFs induces PD pathologies,motor dysfunctions,and cognitive impairments.Thus,δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS. | Eun Hee Ahn Seong Su Kang Xia Liu Guiqin Chen Zhentao Zhang Bindu Chandrasekharan Ashfaqul M.Alam Andrew S.Neish Xuebing Cao Keqiang Ye | 2020 | Cell Research2020，30，1： | 9 |
| 4 | Antioxidant potential of silk protein sericin against hydrogen peroxide-induced oxidative stress in skin fibroblasts 显示文摘 | Dash R Acharya C Bindu P C | 2008 | BMB Rep2008，41，3： | 1 |
| 5 | Enhanced production of cellulase-free thermostable xylanase by Bacillus pumilus ASH and its potential application in paper industry 显示文摘 | Bindu Banan Jitender Sharma Saurabh Sudha Dhiman Ramesh Chander Kuhad | 2007 | Enzyme and Microbial Technology2007，41，： | 1 |
| 6 | Angiotensin-converting enzyme (rs4646994) and ex ADDUCIN (rs4961) gene polymorphisms' study in primary spontaneous intracerebral hemorrhage显示文摘 | Kalita J Misra U K Bindu I S | 2011 | Neurol India2011，59，1： | 1 |
| 7 | Mobilization and domain of bone marrow stromal cells in myocardial infarction显示文摘 | Bindu B Dominique S Abdulaziz A | 2003 | Eur J Cardio Surg2003，24，： | 1 |
| 8 | Physico-chemical changes in high pressure treated Indian white prawn (Fenneropenaeus indicus) during chill storage显示文摘 | Bindu J Ginson J Kamalakanth C | 2013 | Innovative Food Science & Emerging Technologies2013，17，： | 1 |
| 9 | Hypoparathyroidism: a rare treatable cause of epilepsy -report of two cases 显示文摘 | Bindu M Harinarayana CV | 2006 | E ur J Neurol2006，13，： | 1 |
| 10 | Addition-cure-type phenolic resin based on alderene reaction: Synthesis and laminate composite properties 显示文摘 | Bindu RL Reghunadhan Nair CP Ninan KN | 2001 | Journal of Applied Polymer Science2001，80，5： | 1 |
| 11 | Institutional reforms and investor reactions to CSR announcements:evidence from an emerging economy显示文摘 | Arya Bindu Zhang Gaiyan | 2009 | Journal of Management Studies2009，46，7： | 1 |
| 12 | Preparation of CuInS2 thin films using CBD CuxS films显示文摘 | BINI S BINDU K LAKSHMI M | 2000 | Renewable Energy2000，20，4： | 1 |
| 13 | Long-Term Propensity Score–Matched Comparison of Percutaneous Closure of Patent Foramen Ovale With Medical Treatment After Paradoxical Embolism显示文摘 | Andreas Wahl Peter Jüni Marie-Luise Mono Bindu Kalesan Fabien Praz Laura Geister Lorenz R?ber Krassen Nedeltchev Heinrich P. Mattle Stephan Windecker Bernhard Meier | 2012 | Circulation2012，，6： | 1 |
| 14 | Clinical and magnetic resonance imaging findings in patients with Leigh syndrome and SURF1 mutations显示文摘 | Kothari Sonam Nahid Akthar Khan Parayil Sankaran Bindu Arun B. Taly N. Gayathri M.M. Srinivas Bharath C. Govindaraju H.R. Arvinda Madhu Nagappa Sanjib Sinha K. Thangaraj | 2013 | Brain and Development2013，，： | 1 |
| 15 | Phenolic resins bearing maleimide functions ; synthesis and characterisation 显示文摘 | Reghunadhan Nair CP Bindu RL Ninan KN | 2000 | Journal of Applied Polymer Science Part A Polymer Chemistry2000，38，2： | 1 |
| 16 | In vitro preprogramming of marrow stromal cells for myocardial regeneration显示文摘 | Bindu B Jin-QK Abdulaziz AK | 2002 | Society Thorac Surg2002，74，4： | 1 |
| 17 | Hormonal activities of 5-ami- nolevulinic acid in callus induction and micro propagation 显示文摘 | BINDU R C VIVEKANANDAN M | 1998 | Plant Growth Regu1998，26，： | 1 |
| 18 | Physico-chemical changes in high pressure treated Indian white prawn ( Fenneropenaeus indicus ) during chill storage显示文摘 | J. Bindu J. Ginson C.K. Kamalakanth K.K. Asha T.K. Srinivasa Gopal | 2012 | Innovative Food Science and Emerging Technologies2012，，： | 1 |
| 19 | A double blind, randomized,controlled trial to study the effect of dexmedeto- midine on hemodynamic and recovery responses during tracheal extubation 显示文摘 | Bindu B Pasupuleti S Gowd UP | 2013 | J Anaesthesiol Clin Pharmacol2013，29，2： | 1 |
| 20 | Modeling of mechanical ablation in thermal protection systems 显示文摘 | Palanianathan R Bindu S | 2005 | Journal of Space craft and Rockets2005，42，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员