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| 1 | Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center显示文摘AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. | Michael Christian Sulz Reto Bertolini Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger | 2014 | World Journal of Gastroenterology2014，20，43： | 17 |
| 2 | Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves显示文摘干旱容忍的草 Brachypodium distachyon 是为适度的草和谷物庄稼的新兴的模型种。为了为干旱探索这种的实用性,学习,一在 vivo 可再现干旱试金被开发。弄干的自发的土壤在叶尺寸导致了 45% 减小,并且这主要由于在细胞扩大的减少,而细胞分割由干旱仍然保持大部分未受影响。调查观察的叶生长减小的分子的基础,第三片 Brachypodium 叶在三个地区被把,也就是增长,扩大,和成熟地区,并且使分析遭到了到 transcriptome,基于一个整个染色体的并列数组。这条途径允许我们加亮不同的发展的叶地区的侧面不同地回答到干旱的那 transcriptome。涉及干旱忍耐的几基因和功能的过程被识别。transcriptome 数据在增长地区建议增加的精力可获得性,与甾醇合成的一条起来规定一起,那可以影响膜流动性。这个信息可以被用来改进适度的谷物的忍耐到干旱,它无疑是今天并且在不久的将来的农业面对的主要环境挑战之一。 | Wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé | 2013 | Molecular Plant2013，6，2： | 6 |
| 3 | Severe delayed complication after percutaneous endoscopic colostomy for chronic intestinal pseudo-obstruction: A case report and review of the literature显示文摘经皮的内视镜的结肠开口术(PEC ) 逐渐地作为外科的一种选择被建议对待各种各样的混乱,包括尖锐结肠的伪阻塞,长期的肠的伪阻塞和复发的 sigmoid 肠扭传。我们在 PEC 放置以后在发生的严重复杂并发症上报导二个月。有自从 8 年起,演变的长期的肠的伪阻塞的历史的一个 74 岁的人被重新接纳到我们的医院并且收到了 PEC 提供长期的地势。过程是平静的并且极大地改进了病人生命的质量。二个月以后,病人开发了尖锐粪的腹膜炎。在剖腹术,结肠开口术凸缘在腹壁被嵌入,但是没有压迫性坏死在结肠的墙的水平被发现。这复杂并发症与结肠开口术试管的不经心的拖拉有关是可能的。有终端回肠造口术的小计结肠切除术被执行。我们考察迄今为止报导的 PEC 的 60 个案例的主要特征,包括指示和复杂并发症。 | David Bertolini Philippe De Saussure Michael Chilcott Marc Girardin Jean-Marc Dumonceau | 2007 | World Journal of Gastroenterology2007，13，15： | 4 |
| 4 | First report of colonoscopic closure of a gastrocolocutaneous PEG migration with over-the-scope-clip-system显示文摘Percutaneous endoscopic gastrostomy(PEG) is a common practice for long-term nutrition of patients who are unable to take oral food. We report of an 85-year old man with a history of recurrent larynx carcinoma and hemicolectomy many years ago due to unknown reason. Laryngectomy was indicated. Preoperatively a PEG was inserted endoscopically after an abdominal ultrasonography without abnormal findings. Few months after PEG insertion, the patient was evaluated for diarrhea and insufficient feeding without signs of infection or peritonism. An upper endoscopy and computed tomography scan confirmed a buried bumper syndrome with migration of the PEG tube into the colon as a rare complication. He underwent successful colonoscopic removal of the internal bumper and closure of the colonic orifice of the fistula with the over-the-scope-clip system(OTSC). OTSC is an endoscopic device for treatment of bleeding, perforation, leak and fistula in the gastrointestinal tract. To the best of our knowledge, this is the first report of the use of OTSC for colonoscopic closure of a gastrocolocutaneous fistula due to a buried bumper syndrome with transcolonic PEG tube migration. | Reto Bertolini Christa Meyenberger Michael Christian Sulz | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 5 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 6 | Primary Lung Cancer Presenting with Gastrointestinal Tract Involvement: Clinicopathologic and Immunohistochemical Features in a Series of 18 Consecutive Cases显示文摘 | Giulio Rossi Alessandro Marchioni Elena Romagnani Federica Bertolini Lucia Longo Alberto Cavazza Fausto Barbieri | 2007 | Journal of Thoracic Oncology2007，，2： | 2 |
| 7 | Liver resection for hepatocellular carcinoma in patients without cirrhosis显示文摘 | A. Thelen C. Benckert H.‐M. Tautenhahn H.‐M. Hau M. Bartels J. Linnemann J. Bertolini M. Moche C. Wittekind S. Jonas | 2012 | Br J Surg2012，，1： | 2 |
| 8 | Sinitrodi 显示文摘 | Cereda R Bertolini G Gromo G | 1997 | Drugs of the Future1997，22，3： | 2 |
| 9 | Associations between serum 25-hydroxyvitamin D 3 concentrations and liver histology in patients with non-alcoholic fatty liver disease显示文摘 | Giovanni Targher Lorenzo Bertolini Luca Scala Massimo Cigolini Luciano Zenari Giancarlo Falezza Guido Arcaro | 2006 | Nutrition Metabolism and Cardiovascular Diseases2006，，7： | 2 |
| 10 | Temporal variability and effect of environmental variables on airborne bacterial communities in an urban area of Northern Italy显示文摘 | Valentina Bertolini Isabella Gandolfi Roberto Ambrosini Giuseppina Bestetti Elena Innocente Giancarlo Rampazzo Andrea Franzetti | 2013 | Applied Microbiology and Biotechnology2013，，14： | 2 |
| 11 | Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia显示文摘Three members of the angiopoietin-like(ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8-are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes. This review focuses on the role of ANGPTL3 as emerged from the study of genetic variants of Angptl3 gene in mice and humans. Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase. In humans with ANGPTL3 deficiency, caused by homozygous loss of function(LOF) variants of Angptl3 gene, the levels of all plasma lipoproteins are greatly reduced. This plasma lipid disorder referred to as familial combined hypolipidemia(FHBL2) does not appear to be associated with distinct pathological manifestations. Heterozygous carriers of LOF variants have reduced plasma levels of total cholesterol and triglycerides and are at lower risk of developing atherosclerotic cardiovascular disease, as compared to non-carriers. These observations have paved the way to the development of strategies to reduce the plasma level of atherogenic lipoproteins in man by the inactivation of ANGPTL3, using either a specific monoclonal antibody or anti-sense oligonucleotides. | Patrizia Tarugi Stefano Bertolini Sebastiano Calandra | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 12 | Gastrointestimd stromal tumors frequency, malignancy, and new prognostic factors : the experi- ence of a single institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 13 | Energy metabolism of thoracic surgical patients in the early postoperative period 显示文摘 | Brandi LS Bertolini R Janni A | 1996 | Chest1996，109，： | 1 |
| 14 | CXCR4 neutralization,a novel therapeutic approach for non-hodgkinps lymphoma显示文摘 | Bertolini F Agnola CD Mancuso P | 2002 | Cancer Res2002，62，： | 1 |
| 15 | Influence of S-adenosly--L-methionine on chronic mild stress-induced anhedonia in castrated rats显示文摘 | Benelli A Filaferro M Bertolini A | 1999 | Br J Pharmacol1999，127，3： | 1 |
| 16 | Effect of temperature during co-nidial formation of Monilinia laxa on conidial size,ger-mination and infection of stored nectarines显示文摘 | Tian S P Bertolini P | 1999 | Journalof Phytopathology1999，147，： | 1 |
| 17 | Biotrans- formations of cinnamic and ferulic acid with Actinomycetes显示文摘 | Brunati M Marinelli F Bertolini C | 2004 | Enzyme and Microbial Technology2004，34，1： | 1 |
| 18 | Primary mixed adenocarci-noma and small cell carcinoma of the appendix : a clinicopatholog-ic, immunohistochemical, and molecular study of a hitherto unre-ported tumor 显示文摘 | Rossi G Bertolini F Sartori G | 2004 | Am J Surg Pathol2004，28，9： | 1 |
| 19 | Evaluation of right ventricular function in patients with a previous episode of pulmonary embolism using tissue Doppler Imaging显示文摘 | Dentali F Bertolini A Nicolini E | 2013 | Intern Emerg Med2013，8，8： | 1 |
| 20 | Anti-VEGF and beyond: shaping a new generation of anti-angiogenic therapies for cancer显示文摘 | Francesco Bertolini Paola Marighetti Ines Martin-Padura Patrizia Mancuso Dana D. Hu-Lowe Yuval Shaked Alberto D’Onofrio | 2011 | Drug Discovery Today2011，，23： | 1 |
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