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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Lack of hepcidin expression attenuates steatosis and causesfibrosis in the liver显示文摘AIM: To investigate the role of key iron-regulatory protein, hepcidin in non-alcoholic fatty liver disease(NAFLD). METHODS: Hepcidin(Hamp1) knockout and floxed control mice were administered a high fat and high sucrose(HFS) or a regular control diet for 3 or 7 mo. Steatosis, triglycerides, fibrosis, protein and gene expression in mice livers were determined by histological and biochemical techniques, western blotting and realtime polymerase chain reaction. RESULTS: Knockout mice exhibited hepatic iron accumulation. Despite similar weight gains, HFS feeding induced hepatomegaly in floxed, but not knockout, mice. The livers of floxed mice exhibited higher levels of steatosis, triglycerides and c-Jun N-terminal kinase(JNK) phosphorylation than knockout mice. In contrast, a significant increase in fibrosis was observed in knockout mice livers within 3 mo of HFS administration. The hepatic gene expression levels of sterol regulatoryelement-binding protein-1c and fat-specific protein-27, but not peroxisome proliferator-activated receptoralpha or microsomal triglyceride transfer protein, were attenuated in HFS-fed knockout mice. Knockout mice fed with regular diet displayed increased carnitine palmitoyltransferase-1a and phosphoenolpyruvate carboxykinase-1 but decreased glucose-6-phosphatase expression in the liver. In summary, attenuated steatosis correlated with decreased expression of lipogenic and lipid storage genes, and JNK phosphorylation. Deletion of Hamp1 alleles per se modulated hepatic expression of beta-oxidation and gluconeogenic genes. CONCLUSION: Lack of hepcidin expression inhibits hepatic lipid accumulation and induces early development of fibrosis following high fat intake. Hepcidin and iron may play a role in the regulation of metabolic pathways in the liver, which has implications for NAFLD pathogenesis. | Sizhao Lu Robert G Bennett Kusum K Kharbanda Duygu Dee Harrison-Findik | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Dimcnsionality reduction via sparse support vector machines 显示文摘 | Bi J Bennett K P Embreehts M | 2003 | Journal of Machine Learn- ing Research2003，3，1： | 1 |
| 5 | Metabolic engineering of Escherichia coli to enhance recombinant protein production through acetate reduction显示文摘 | Aristidou A A San K Y Bennett G N | 1995 | Biotechnol Prog1995，11，： | 1 |
| 6 | Thermostable xylanase10B from Clostridium acetobutylicum ATCC824 显示文摘 | Ali M K Rudolph F B Bennett G N | 2004 | J Industrial Microbiol Biotechnol2004，，： | 1 |
| 7 | Era- bolus extravasation is an alternative mechanism for cere- bral microvascular recanalization 显示文摘 | Carson K Lam Taehwan Yoo Bennett Hiner | 2010 | Nature2010，465，： | 1 |
| 8 | Observational modeling effectsfor movements dynamics and movement outcome measured acrossdiffering task constraint: a meta-analysis 显示文摘 | Ashford D Bennett S Davids K | 2006 | Journal of Motor Be-havior2006，38，3： | 1 |
| 9 | The 'digital natives' debate: A critical review of the evidence显示文摘 | Bennett S Maton K & Kervin L | 2008 | British journal of educational technology2008，，5： | 1 |
| 10 | Germline Epigenetic Regulation of KILLIN in Cowden and Cowden-like Syndrome 显示文摘 | Bennett K L Mester J Eng C | 2010 | J AMA-J Am Med Assoc2010，304，24： | 1 |
| 11 | Prader-Willi syndrome and obstructive sleep apnea: co-occurrence in the pediatric population 显示文摘 | Sedky K Bennett DS Pumariega A | 2014 | J Clin Sleep Med2014，10，4： | 1 |
| 12 | Reports of body pain in a dental student population显示文摘 | Rising DW Bennett BC Hursh K | 2005 | J Am Dent Assoc2005，136，1： | 1 |
| 13 | Revised recom- mendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leu- kemia显示文摘 | Cheson BD Bennett JM Kopecky K J | 2003 | J clin Onco12003，21，24： | 1 |
| 14 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man显示文摘 | Bennett G J Xie Y K | 1988 | Pain1988，33，1： | 1 |
| 15 | Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract显示文摘 | N'Dow J Pearson J P Bennett M K | 2000 | J Urol2000，164，4： | 1 |
| 16 | Lead iodide optical detectors for gamma ray spectroscopy显示文摘 | SHAH K S BENNETT P KLUGERMAN M | 1997 | IEEE Trans Nucl Sci1997，44，3： | 1 |
| 17 | Cake resistance and force balance mechanism in the crossflowmicrofiltration of lactalbumin partides显示文摘 | Harit K Vyas R J Bennett A D | 2001 | J Membr Sci2001，，192： | 1 |
| 18 | Measuring the Consumer Benefits of Improving Farm animal Welfare to Inform Welfare Labelling 显示文摘 | Kehlbacher A Bennett R Balcombe K | 2012 | Food Policy2012，37，6： | 1 |
| 19 | A peripheral mononeuropathy in rat that pro- duces disorders of pain sensation like those seen in man 显示文摘 | Bennett G J Xie Y K | 1988 | Pain1988，33，1： | 1 |
| 20 | expert committee on the diagnosis and classification of diabetes mellitus: follow-up report on the diagnosis of diabetes mellitus 显示文摘 | GENUTH S ALBERTI K G BENNETT P | 2003 | Diabetes Care2003，26，11： | 1 |
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