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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 3 | Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study显示文摘 | Axel Bauer Jan W Kantelhardt Petra Barthel Raphael Schneider Timo M?kikallio Kurt Ulm Katerina Hnatkova Albert Sch?mig Heikki Huikuri Armin Bunde Marek Malik Georg Schmidt | 2006 | The Lancet2006，，9523： | 3 |
| 4 | Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery显示文摘 | Axel DI Kunert W Goggelmann C | 1997 | Circulation1997，96，2： | 1 |
| 5 | Cyclodextrin rotaxanes and polyrotaxanes显示文摘 | Gerhard W Han B H Axel M | 2006 | Chemical Reviews2006，106，： | 1 |
| 6 | Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery显示文摘 | Axel DI Kunert W Goggelmann C | 1997 | Circulation1997，96，2： | 1 |
| 7 | A formula to calculate the standard liver volume in children and its application in pediatric liver transplantation 显示文摘 | Uta H Friedel W Axel H | 2013 | Transplant Internationa2013，26，12： | 1 |
| 8 | Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery显示文摘 | Axel DI Kunert W Goggelmann C | 1997 | Circulation1997，96，： | 1 |
| 9 | Decleration capacity of heart rate as a prelictor of mortality after myocardial infarction~ cohort study 显示文摘 | Axel B Jan W K Petra B | 2006 | Lancet2006，367，9523： | 1 |
| 10 | Operation of a Miniature Redox Hydrogel-Based Pyruvate Sensor in Undiluted Deoxygenated Calf Serum显示文摘 | Gajovic N Binyamin G Axel W | 2000 | Analytical Chemistry2000，72，13： | 1 |
| 11 | Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery显示文摘 | Axel DI Kunert W | 1997 | Circulation1997，1596，2： | 1 |
| 12 | Combing Lithoclast and ultrasound power in one device for percutaneous nephrolithotomy: In vitro results of a novel and highly effective technology 显示文摘 | Peter O Jost W Axel H | 2003 | Urology2003，61，1： | 1 |
| 13 | An equilibrium model of search employment显示文摘 | ALBRECHT J W AXELL B | 1984 | Journal of Political Economy1984，92，： | 1 |
| 14 | Paclitaxel in- hibits arterial smooth muscle cell proliferation and migra- tion in vitro and in vivo using local drag delivery 显示文摘 | Axel D I Kunert W Grogelman C | 1997 | Circulation1997，96，2： | 1 |
| 15 | The neurally controlled animat:biological brauns acting with simulated bodues 显示文摘 | Daniel A Wagenaar Axel W Blau Steve M Potter | 2001 | Autonomous Robots2001，11，： | 1 |
| 16 | Development of a powder metallurgy process for tungsten components显示文摘 | VOLKER P BERTHOLD Z PRACHAI N ROBERT R AXEL V W JUERGEN H | 2008 | Fusion Engineering and Design2008，83，1012： | 1 |
| 17 | An equilibrium model of search employment显示文摘 | Albrecht J W and B Axell | 1984 | Journal of Political Economy1984，92，： | 1 |
| 18 | Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery显示文摘 | Kunert W Goggelmann C | 1997 | Circulation1997，96，2： | 1 |
| 19 | Analysis of Recognition of Fructose by Imprinted Polymers显示文摘 | Rajagopal R Axel W Helmuth M | 2008 | Talanta2008，76，5： | 1 |
| 20 | Paclitaxel inhibits arterial smoothmusclecel proliferation andmigration in vitroand invivousing local drug delivery显示文摘 | Axel DI Kunert W Goggelmann C | | 0，，： | 1 |
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