5篇
您的检索式：作者名="Axel Behrens"
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| 1 | Re-treatment of Children With Chronic Hepatitis C Who Did Not Respond to Interferon-α Treatment显示文摘 | Patrick Gerner Juliane Hilbich Tobias G Wenzl Rolf Behrens Frank Walther Guido Kliemann Axel Enninger Stefan Wirth | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 2 | The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer显示文摘 | Madhu S. Kumar David C. Hancock Miriam Molina-Arcas Michael Steckel Phillip East Markus Diefenbacher Elena Armenteros-Monterroso Fran?ois Lassailly Nik Matthews Emma Nye Gordon Stamp Axel Behrens Julian Downward | 2012 | Cell2012，，3： | 1 |
| 3 | Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain显示文摘 | Gennadij Raivich Axel Behrens | 2006 | Progress in Neurobiology2006，，6： | 1 |
| 4 | Chemically induced hypoxia by dimethyloxalylglycine(DMOG)-loaded nanoporous silica nanoparticles supports endothelial tube formation by sustained VEGF release from adipose tissue-derived stem cells显示文摘Inadequate vascularization leading to insufficient oxygen and nutrient supply in deeper layers of bioartificial tissues remains a limitation in current tissue engineering approaches to which prevascularization offers a promising solution.Hypoxia triggering pre-vascularization by enhanced vascular endothelial growth factor(VEGF)expression can be induced chemically by dimethyloxalylglycine(DMOG).Nanoporous silica nanoparticles(NPSNPs,or mesoporous silica nanoparticles,MSNs)enable sustained delivery of molecules and potentially release DMOG allowing a durable capillarization of a construct.Here we evaluated the effects of soluble DMOG and DMOG-loaded NPSNPs on VEGF secretion of adipose tissue-derived stem cells(ASC)and on tube formation by human umbilical vein endothelial cells(HUVEC)-ASC co-cultures.Repeated doses of 100 mM and 500 mM soluble DMOG on ASC resulted in 3-to 7-fold increased VEGF levels on day 9(P<0.0001).Same doses of DMOG-NPSNPs enhanced VEGF secretion 7.7-fold(P<0.0001)which could be maintained until day 12 with 500 mM DMOG-NPSNPs.In fibrin-based tube formation assays,100 mM DMOG-NPSNPs had inhibitory effects whereas 50 mM significantly increased tube length,area and number of junctions transiently for 4 days.Thus,DMOG-NPSNPs supported endothelial tube formation by upregulated VEGF secretion from ASC and thus display a promising tool for prevascularization of tissue-engineered constructs.Further studies will evaluate their effect in hydrogels under perfusion. | Sarah Zippusch Karen FWBesecke Florian Helms Melanie Klingenberg Anne Lyons Peter Behrens Axel Haverich Mathias Wilhelmi Nina Ehlert Ulrike Boer | 2021 | Regenerative Biomaterials2021，8，5： | 0 |
| 5 | Nat Cell Biol:研究发现乳腺癌的新型细胞起源显示文摘乳腺癌是女性常见的癌症类型之一,长期以来科学家们知道并不是所有的乳腺癌都是相似的,腔体肿瘤主要包含一些和乳腺管内层细胞非常相似的细胞类型,而其它肿瘤所包含的细胞则同乳腺上皮组织外层的细胞相似,研究者认为,这种多样性起源于不同干细胞或祖细胞的突变, | Leander Blaas, Agneta B. Andersson, Marco Gerling, Alexandra Musch, Dorothee Bornhorst Rune Toftg #x000E5 rd Fabio Pucci, Hendrik A. Messal, E. Josue Ruiz Axel Behrens Iyadh Douagi Bradley Spencer-Dene, Richard Stone Gordon Stamp Richard Mitter Leena Bhaw Abdul K. Sesay Jos Jonkers Ilaria Malanchi Axel Behrens | 2017 | 现代生物医学进展2017，17，8： | 0 |
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