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| 1 | 高效抗病毒治疗促使艾滋病患者免疫功能重建显示文摘The characteristics of AIDS is that HIV infection induces CD4+ T cell defects that includes a quantitave CD4+ T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4+ and CD8+ T cells followed by a slower CD4+ T cell increase; (2) a rapid rise in memory CD4+ T cells during the first three months of treatment by late increase in naive T cells coexpressing CD45RA and CD62L molecules after 3 months of efficient antiviral treatment;(3) a significant reduction of CD4 and CD8 activation markers in parallel to plasma virus load reduction;(4) a restoration in CD4+ T cell reactivity to recall antigens. These observations open new perspectives for the understanding of CD4+ T cells deficiency and therapeutic strategies of HIV infection. In the present review we will address some of the questions raised by immune restoration with HAART when administered at advanced stages of the disease. | 李太生 Guislaine Carcelaine Patrice Debre Brigitte Autran | 2001 | 基础医学与临床2001，21，1： | 14 |
| 2 | 20例艾滋病病人经高效联合抗病毒治疗后免疫重建研究显示文摘目的 对接受高效联合抗逆转录病毒治疗 (HAART)后的晚期人类免疫缺陷病毒 1型(HIV 1)感染者的免疫功能重建的可能性和影响因素进行探讨。方法 用开放性前瞻性研究方法 ,对2 0例接受由 1种HIV蛋白酶抑制剂和 2种逆转录酶抑制剂联合组成的HAART的HIV 1病人 ,在治疗前和治疗后 1、3、6、9、12个月时 ,分别测定病人对巨细胞病毒和结核菌抗原的特异性CD4+ T细胞免疫应答反应。结果 经 1年的HAART ,2 0例HIV病人的血浆HIV载量平均下降了 1 5lg拷贝 /ml,CD4+T细胞计数平均上升 6 3个 / μl。开始HAART前 ,仅有 4位患者对特异性抗原有反应 ,治疗 1年后有 10例患者重新恢复了对特异抗原的免疫反应 (P <0 0 0 1)。与无免疫应答者相比 ,免疫应答者血浆HIV载量显著减少 ,并持续维持 ,CD4+ T细胞计数明显增加。结论 HAART治疗能够恢复艾滋病病人CD4+ T细胞抗机会病原体的免疫功能 ,这种恢复与治疗前已破坏的免疫功能严重程度无关 ,而取决于治疗后CD4+ T细胞增加的幅度、病毒复制被控制的程度和持续时间。 | 李太生 Katlama C Autran B | 2003 | 中华检验医学杂志2003，26，5： | 13 |
| 3 | Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices显示文摘BACKGROUND Cyanoacrylate(CYA)injection can be performed using a standard upper endoscopy technique or under endoscopic ultrasound(EUS)guidance alone or in combination with coils.There is little information available on the economic impact of these treatment methods.AIM To compare the cost-effectiveness of treating gastric varices by CYA injection via upper endoscopy vs coils plus CYA guided by EUS.METHODS This was an observational,descriptive,and retrospective study.Patients were allocated into two groups:A CYA group and coils plus CYA group.The baseline characteristics were compared,and a cost analysis was performed.RESULTS Overall,36 patients were included(19 in the CYA group and 17 in the coils+CYA group).All patients in the CYA group had acute bleeding.They underwent a higher mean number of procedures(1.47 vs 1,P=0.025),and the mean volume of glue used was 2.15 vs 1.65 mL,P=0.133.The coils+CYA group showed a higher technical success rate(100%vs 84.2%),with a complication rate similar to the CYA group.The majority of CYA patients required hospitalization,and although the mean total per procedure cost was lower(United States$1350.29 vs United States$2978),the mean total treatment cost was significantly different(United States$11060.89 for CYA vs United States$3007.13 for coils+CYA,P=0.03).CONCLUSION The use of EUS-guided coils plus cyanoacrylate is more cost-effective than cyanoacrylate injection when the total costs are evaluated.Larger,randomized trials are needed to validate the cost-effectiveness of the EUS-guided approach to treat gastric varices. | Carlos Robles-Medranda Joao Autran Nebel Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Jesenia Ospina-Arboleda Manuel Valero Hannah Pitanga-Lukashok | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，1： | 4 |
| 4 | Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions:A single-center study显示文摘BACKGROUND Currently,there is insufficient data about the accuracy in the diagnosing of pancreatic cystic lesions(PCLs),especially with novel endoscopic techniques such as with direct intracystic micro-forceps biopsy(mFB)and needle-based confocal laser-endomicroscopy(nCLE).AIM To compare the accuracy of endoscopic ultrasound(EUS)and associated techniques for the detection of potentially malignant PCLs:EUS-guided fine needle aspiration(EUS-FNA),contrast-enhanced EUS(CE-EUS),EUS-guided fiberoptic probe cystoscopy(cystoscopy),mFB,and nCLE.METHODS This was a single-center,retrospective study.We identified patients who had undergone EUS,with or without additional diagnostic techniques,and had been diagnosed with PCLs.We determined agreement among malignancy after 24-mo follow-up findings with detection of potentially malignant PCLs via the EUSguided techniques and/or EUS-guided biopsy when available(EUS malignancy detection).RESULTS A total of 129 patients were included, with EUS performed alone in 47/129. In 82/129 patients,EUS procedures were performed with additional EUS-FNA (21/82), CE-EUS (20/82), cystoscopy(27/82), mFB (36/82), nCLE (44/82). Agreement between EUS malignancy detection and the 24-mo follow-up findings was higher when associated with additional diagnostic techniques thanEUS alone [62/82 (75.6%) vs 8/47 (17%);OR 4.35, 95%CI: 2.70-7.37;P < 0.001]. The highestmalignancy detection accuracy was reached when nCLE and direct intracystic mFB were bothperformed, with a sensitivity, specificity, positive predictive value, negative predictive value andobserved agreement of 100%, 89.4%, 77.8%, 100% and 92.3%, respectively (P < 0.001 comparedwith EUS-alone).CONCLUSIONThe combined use of EUS-guided mFB and nCLE improves detection of potentially malignantPCLs compared with EUS-alone, EUS-FNA, CE-EUS or cystoscopy. | Carlos Robles-Medranda Juan I Olmos Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Martha Arevalo-Mora Raquel Del Valle Zavala Joao Autran Nebel Daniel Calle Loffredo Hannah Pitanga-Lukashok | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，3： | 2 |
| 5 | Enhancer detection and gene trapping as tools for functional genomics in plants 显示文摘 | Acosta-Garcia G Autran D Vielle-Calzada J P | 2004 | Methods Mol Biol2004，267，： | 1 |
| 6 | Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine(vCP1452)显示文摘 | Autran B Murphy RL Costagliola D | 2008 | AIDS2008，1122，11： | 1 |
| 7 | Positive effects of combined antiretroviral therapy on CD4 + T cell homeostasis and function in advanced HIV disease显示文摘 | Autran B Carcelain G Li TS | 1997 | Science1997，277，5322： | 1 |
| 8 | Tantalum Pentoxide ( Ta2 05 ) Thin Films for Advanced Dielectric Applications 显示文摘 | Chaneliero C Autran J L Devine R A B | 1998 | Materials Science and Engineering1998，22，： | 1 |
| 9 | Tantalum pentoxide(Ta2Os) thin films for advanced dielectric applications显示文摘 | CHANELIERE C AUTRAN J L DEVINE R A B BALLAND B | 1998 | Materials Science and Engineering R1998，22，： | 1 |
| 10 | Barriers to a cure for H/V: new ways to target and eradicate HIV-1 reservoirs 显示文摘 | Katlama C Deeks SG Autran B | 2013 | Lancet (London England)2013，381，9883： | 1 |
| 11 | Chromosome 1B - encoded glidins and glutenin subunits in durum wheat : Genetics and relationship to gluten strength 显示文摘 | Pogna N E Autran J C Mellini F | 1990 | Journal of Cereal Science1990，，11： | 1 |
| 12 | Maternal Epigenetic Pathways Control Parental Contributions to Arabidopsis Early Embryogenesis显示文摘 | Daphné Autran Célia Baroux Michael T. Raissig Thomas Lenormand Michael Wittig Stefan Grob Andrea Steimer Matthias Barann Ulrich C. Klostermeier Olivier Leblanc Jean-Philippe Vielle-Calzada Phillip Rosenstiel Daniel Grimanelli Ueli Grossniklaus | 2011 | Cell2011，，5： | 1 |
| 13 | X-radiation response of SIMOX buried oxides:influence of the fabrication process显示文摘 | Paillet P Autran J L Flament O | 1996 | IEEE Transactions on Nuclear Science1996，43，2： | 1 |
| 14 | Positive effects of combine dantiretro-viral therapy on CD4+T cell homeostasis and function in advanced HIV disease显示文摘 | Autran B Carcelain G Li TS | 1997 | Science1997，277，5322： | 1 |
| 15 | T cell receptor gamma/delta+lymphocyte subsets during HIV infection显示文摘 | Autran B Triebel F Katlama C Rozenbaum W Hercend T Debre P | 1989 | Clin Exp Immunol1989，75，2： | 1 |
| 16 | Barriers to a cure for HIV:new ways to target and eradicate HIV-1 reservoirs显示文摘 | Katlama C Deeks SG Autran B | 2013 | Lancet2013，381，9883： | 1 |
| 17 | Inter-agent communication in IMAGO prolog显示文摘 | AUTRAN G | 2005 | Lecture Notes in Artificial Intelligence2005，，： | 1 |
| 18 | Therapeuie vaeeines a- gainst HIV need international partnerships显示文摘 | Autran B Debre P Walker B | 2003 | Nat Revimmu- nol2003，3，6： | 1 |
| 19 | On the tunneling component of charge pumping current in ultrathin gate oxide MOSFET's 显示文摘 | MASSON P AUTRAN J L BRIRII J | 1999 | IEEE Elec Dev Lett1999，20，2： | 1 |
| 20 | T-cell subse Eounting and the fight against AIDS: reflection sorer a 20-year struggle' 显示文摘 | Mandy E Nieholson J Autran B | 2002 | Cytometry2002，50，： | 1 |
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