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| 1 | 20例艾滋病病人经高效联合抗病毒治疗后免疫重建研究显示文摘目的 对接受高效联合抗逆转录病毒治疗 (HAART)后的晚期人类免疫缺陷病毒 1型(HIV 1)感染者的免疫功能重建的可能性和影响因素进行探讨。方法 用开放性前瞻性研究方法 ,对2 0例接受由 1种HIV蛋白酶抑制剂和 2种逆转录酶抑制剂联合组成的HAART的HIV 1病人 ,在治疗前和治疗后 1、3、6、9、12个月时 ,分别测定病人对巨细胞病毒和结核菌抗原的特异性CD4+ T细胞免疫应答反应。结果 经 1年的HAART ,2 0例HIV病人的血浆HIV载量平均下降了 1 5lg拷贝 /ml,CD4+T细胞计数平均上升 6 3个 / μl。开始HAART前 ,仅有 4位患者对特异性抗原有反应 ,治疗 1年后有 10例患者重新恢复了对特异抗原的免疫反应 (P <0 0 0 1)。与无免疫应答者相比 ,免疫应答者血浆HIV载量显著减少 ,并持续维持 ,CD4+ T细胞计数明显增加。结论 HAART治疗能够恢复艾滋病病人CD4+ T细胞抗机会病原体的免疫功能 ,这种恢复与治疗前已破坏的免疫功能严重程度无关 ,而取决于治疗后CD4+ T细胞增加的幅度、病毒复制被控制的程度和持续时间。 | 李太生 Katlama C Autran B | 2003 | 中华检验医学杂志2003，26，5： | 13 |
| 2 | Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine(vCP1452)显示文摘 | Autran B Murphy RL Costagliola D | 2008 | AIDS2008，1122，11： | 1 |
| 3 | Positive effects of combined antiretroviral therapy on CD4 + T cell homeostasis and function in advanced HIV disease显示文摘 | Autran B Carcelain G Li TS | 1997 | Science1997，277，5322： | 1 |
| 4 | Tantalum Pentoxide ( Ta2 05 ) Thin Films for Advanced Dielectric Applications 显示文摘 | Chaneliero C Autran J L Devine R A B | 1998 | Materials Science and Engineering1998，22，： | 1 |
| 5 | Tantalum pentoxide(Ta2Os) thin films for advanced dielectric applications显示文摘 | CHANELIERE C AUTRAN J L DEVINE R A B BALLAND B | 1998 | Materials Science and Engineering R1998，22，： | 1 |
| 6 | Barriers to a cure for H/V: new ways to target and eradicate HIV-1 reservoirs 显示文摘 | Katlama C Deeks SG Autran B | 2013 | Lancet (London England)2013，381，9883： | 1 |
| 7 | Positive effects of combine dantiretro-viral therapy on CD4+T cell homeostasis and function in advanced HIV disease显示文摘 | Autran B Carcelain G Li TS | 1997 | Science1997，277，5322： | 1 |
| 8 | T cell receptor gamma/delta+lymphocyte subsets during HIV infection显示文摘 | Autran B Triebel F Katlama C Rozenbaum W Hercend T Debre P | 1989 | Clin Exp Immunol1989，75，2： | 1 |
| 9 | Barriers to a cure for HIV:new ways to target and eradicate HIV-1 reservoirs显示文摘 | Katlama C Deeks SG Autran B | 2013 | Lancet2013，381，9883： | 1 |
| 10 | Therapeuie vaeeines a- gainst HIV need international partnerships显示文摘 | Autran B Debre P Walker B | 2003 | Nat Revimmu- nol2003，3，6： | 1 |
| 11 | T-cell subse Eounting and the fight against AIDS: reflection sorer a 20-year struggle' 显示文摘 | Mandy E Nieholson J Autran B | 2002 | Cytometry2002，50，： | 1 |
| 12 | Tantalum Pentoxide (Ta200 Thin Films for Advanced Dielectric Applications 显示文摘 | Chaneliere C Autran J L Devine R A B | 1998 | Materials Science and Engineering1998，22，： | 1 |
| 13 | Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection显示文摘 | Chouquet C Autran B Gomard E etal | 2002 | AIDS2002，16，18： | 1 |
| 14 | Therapeutic vac-cines for chronic infections显示文摘 | Autran B Carcelain G Combadiere B | 2004 | Science2004，305，5681： | 1 |
| 15 | 显示文摘 | Chaneliere C Autran J L Devine R A B | 1998 | Mater Sci Eng R1998，22，： | 1 |
| 16 | Positive effects of combined antiretroviral therapy on CD4+ T cellhomeostasis and function in ad-vanced HIV disease 显示文摘 | Autran B Carcelain G Li T S | 1997 | Science1997，277，5322： | 1 |
| 17 | Positive effects of combined antiretroviral therapy on CD4^+T-cell homeostasis and function in advanced HIV disease显示文摘 | Autran B | 1997 | Science1997，277，5322： | 1 |
| 18 | Therapeutic Vaccines for Chronic Infections 显示文摘 | Autran B Carcelain G Combadiere B | 2004 | Science2004，305，5681： | 1 |
| 19 | Consistency of routine measurements of CD4 + ,CD8 + peripheral blood lymphocytes 显示文摘 | ABOULKER JP AUTRAN B BELDJORD K | 1992 | J ImmunolMethods1992，154，2： | 1 |
| 20 | Post-treatment HIV-1 controllers with a long- term virological remission after the interruption of early ini- tiated antiretroviral therapy ANRS VISCONTI Study 显示文摘 | Sfiez-Ciri6n A Bacchus C Hocqueloux L Avettand-Fenoel V Girault I Lecuroux C Potard V Versmisse P Melard A Prazuck T Descours B Guergnon J Viard JP Boufassa F Lambotte O Goujard C Meyer L Costagliola D Venet A Pancino G Autran B Rouzioux C ANRS VISCONTI Study Group | 2013 | PLoS Pathog2013，9，10： | 1 |
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