5篇
您的检索式：作者名="Aurelien David"
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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | 采用Linux与DSP/B_OSRTOS实施双OS信号处理技术显示文摘在系统性能与编程简易性之间的权衡折中是通用操作系统与实时操作系统之间的主要区分点之一。
GPOS(通用操作系统)倾向于提供较高程度的资源抽象,这不仅可通过支持软件模块与资源隔离来提高应用的便携性、简化开发流程,同时还能增强系统的稳健性,这使GPOS成为诸如网络、用户界面以及显示管理等通用系统组件的理想选择。 | Steve Preissig David Beal Aurelien Jacquiot | 2009 | 电子设计技术 EDN CHINA2009，，3： | 4 |
| 3 | Photonic-crystal GaN light-emitting diodes with tailored guided modes distribution显示文摘 | Aurelien David Rajat Sharma T F Kelly McGroddy | 2006 | Applied Physics Letters2006，88，061124： | 1 |
| 4 | Optimization of Light-Diffracting Photonic-Crystas for High Extraction Efficiency LEDs 显示文摘 | AURELIEN DAVID HENRI BENISTY CLAUDE WEISBUCH | 2007 | Journal of Display Technology2007，3，2： | 1 |
| 5 | WNT/β-catenin pathway activation in wilms tumors:a unifying mechanism with multiple entries?显示文摘 | CORBIN M AURELIEN D R DAVID S R | 2009 | Genes Chromosomes & Cancer2009，48，9： | 1 |
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