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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | BISON-C Upgraded One-Dimensional Transport And Bumup Calculation Code For Unix System显示文摘 | Jerzy C Piotr G | 2000 | Nuclear Science and Engineering2000，134，： | 1 |
| 4 | Functional In Vivo delivery of multiplexed anti- HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge 显示文摘 | Jie hua Zhou C Preston Neff Piotr Swiderski | 2013 | Mol ecular Therapy2013，21，1： | 1 |
| 5 | Unconscious emotion显示文摘 | Piotr Winkielman & Kent C Berridge | 2004 | Current Direction in Psychological Science2004，13，3： | 1 |
| 6 | AmberFFC,a flexible program to convert amber and glycam force fields for use with commercial molecular modeling packages显示文摘 | AURELIEN D PIOTR C NICOLAS H | 2001 | Molecular Modeling Annual2001，7，11： | 1 |
| 7 | Effects of concentration on the performance of erbium-doped fiber amplifiers 显示文摘 | PIOTR M DUNG N JACEK C | 1997 | Journal of Lightzoave Technology1997，15，1： | 1 |
| 8 | Direct methanol fuel cells: progress in cell performance and cathode research显示文摘 | Sharon C Thomas Xiaoming Ren Shimshon Gottesfeld 2 Piotr Zelenay | 2002 | Electrochimica Acta2002，，22： | 1 |
| 9 | Barrier role of ABC family of proteins in human placenta显示文摘 | Danuta KR Piotr C | 2011 | Ginekol Pol2011，82，1： | 1 |
| 10 | Possibilistic construction of fuzzy outranking relation for multiple-criteria ranking显示文摘 | Piotr C Roman S | 1996 | Fuzzy Set and System1996，81，： | 1 |
| 11 | The single-step method of RNA i solation by acid guanidinium thiocyanate-phenol-chloroform extraction: twentysomething years on 显示文摘 | PIOTR C NICOLETTA S | 2006 | Nature Protocols2006，1，2： | 1 |
| 12 | The effect of nitrogen fertilization of radish yielding 显示文摘 | Piotr C Eugeniusz K | 2011 | Acta Seientiarum Polonorum Hortorum Cuhus2011，10，1： | 1 |
| 13 | Review of sewage sludge management: standards, regulations and analytical meth ods显示文摘 | Bart]omiej M C Jacek N Piotr K | 2015 | J Clean Prod2015，90，： | 1 |
| 14 | Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents显示文摘 | PIOTR C ZBIGNIEW P JANA S | 2008 | Carbohydrate Research2008，343，： | 1 |
| 15 | Study of hydraulic parameters in heterogeneous gravel beds: constructed wetland in Nowa Stupia (Poland) 显示文摘 | PIOTR M PRZEMYSLAW W PIOTR C | 2006 | Journal of Hydrology2006，331，34： | 1 |
| 16 | SBA-15 mesoporous silica modified with rhodium by MDD method and its catalytic role for N2O decomposition reaction显示文摘 | Lucjan C Piotr K Marek D | 2011 | J Porous Mater2011，18，： | 1 |
| 17 | Thermal properties of complexes of amaranthus starch with selected metal salts 显示文摘 | Wojciech C Piotr T | 2003 | Thermochimica Acta2003，403，： | 1 |
| 18 | An uncontrolled trial of cytisine(Tabex)for smoking cessation 显示文摘 | Witold Z Magdalena C Piotr T | 2006 | Tob Control2006，15，6： | 1 |
| 19 | The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction: twenty-something years on nature protocols 显示文摘 | Piotr C Nicolctta S | 2006 | NatProtoc2006，1，2： | 1 |
| 20 | ^89Sr versus ^153Sm -EDTMP: Comparsion of treatment efficacy of painful bone metastases in prostate and breast carcinoma 显示文摘 | Msaciej B Rafal C Piotr M | 2007 | Nuclear Med Com2007，28，4： | 1 |
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