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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Endoscopic ultrasound-guided celiac plexus neurolysis显示文摘Endoscopic celiac plexus neurolysis(CPN)has become the procedure of choice for the management of patients with pancreatic cancer and abdominal pain unresponsive to medical treatment.It is necessary to differentiate between CPN and endoscopic celiac plexus block performed in patients with benign disease.In this review we describe the technique of this procedure with special emphasis on technical details. | Assaad M Soweid Cecilio Azar | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 3 |
| 3 | Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy显示文摘AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation. | Assaad M Soweid Shadi R Yaghi Faek R Jamali Abdallah A Kobeissy Michella E Mallat Rola Hussein Chakib M Ayoub | 2011 | World Journal of Gastroenterology2011，17，47： | 2 |
| 4 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 5 | Kinetics and thermodynamics studies of copper exchange on Na-montmorillonite clay mineral显示文摘 | El B M Sadek O M Assaad F F | 2003 | Journal of Colloid and Interface Science2003，，2： | 1 |
| 6 | Malonyl-CoA signaling,lipid partitioning,and glucolipotoxicity:role in beta-cell adaptation and failure in the etiology of diabetes显示文摘 | PRENTKI M JOJY E EL ASSAAD W | 2002 | Diabetes2002，51，3： | 1 |
| 7 | Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death显示文摘 | EL ASSAAD W BUTEA J PEYOT M L | 2003 | Endocrinology2003，144，9： | 1 |
| 8 | Closely related receptor complexes differ in their ABA selectivity and sensitivity 显示文摘 | Szostkiewicz I Richter K Kepka M Demmel S Na Y Korte A Assaad F F Christmann A Grill E | 2010 | Plant Journal2010，61，1： | 1 |
| 9 | Conjunctival autograft failure in eyes previously exposed to beta radiation or mitomycin显示文摘 | Assaad N N Coroneo M T | 2008 | Arch Ophthalmol2008，126，10： | 1 |
| 10 | The utility of PAX8 and IMP3 stains in the differential diagnosis of benign, premalignant, and malignant endocervical glandular lesions 显示文摘 | Danialan R Assaad M Burghardt J | 2013 | Gynecol Oncol2013，130，2： | 1 |
| 11 | Kinetics and thermodynamics studies of copper exchange on Namontmorillonite clay mineral显示文摘 | El-Batouti M Sadek O M Assaad F F 2003 | 2003 | J Colloid Interface Sci2003，259，： | 1 |
| 12 | Joint Scheduling and Resource Alloca- tion in the OFDMA Downlink: Utility Maxi- mization Under Imperfect Channel-State Information显示文摘 | AGGARWAL R ASSAAD M KOKSAL C E | 2011 | IEEE Transactions on Signal Processing2011，59，11： | 1 |
| 13 | Recirculation and Flow Field Regimes of Unconfined Non-Reacting Swirling Flows 显示文摘 | Yasir M A1 Abdeli Assaad R Masri | 2003 | Experimental Thermal and Fluid Science2003，27，65： | 1 |
| 14 | Liberalized fluid protocol and tissue perfusion biomarkers inlung resection surgery 显示文摘 | ASSAAD S PERKAL M KYRIAKIDES T | 2012 | Anesth Analg2012，114，5： | 1 |
| 15 | Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study显示文摘 | Khaled M Musallam Hani M Tamim Toby Richards Donat R Spahn Frits R Rosendaal Aida Habbal Mohammad Khreiss Fadi S Dahdaleh Kaivan Khavandi Pierre M Sfeir Assaad Soweid Jamal J Hoballah Ali T Taher Faek R Jamali | 2011 | The Lancet2011，，9800： | 1 |
| 16 | Diagnostic accuracy of imageguided percutaneous fine needle aspiration biopsy of the mediastinum显示文摘 | Assaad M W Pantanowitz L Otis CN | 2007 | Diagn Cytopathol2007，35，11： | 1 |
| 17 | Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum显示文摘 | Assaad M W Pantanowitz L Otis C N | 2007 | Diagn Cytopathol2007，35，11： | 1 |
| 18 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 1 |
| 19 | Simultaneous Rayleigh temperature, OH-and CH2O-LIF Imaging of Meth- ane Jets in a Vitiated Coflow 显示文摘 | Robert L G Assaad R M Epaminondas M | 2008 | Combustion and Flame2008，155，12： | 1 |
| 20 | A non-linear combination of the forecast of rainfall-runoff models by the first-order Takagi-Sugeno fuzzy system显示文摘 | Lihua Xiong Assaad Y Shamseldin Kieran M O Connor | 2001 | Journal of Hydrology2001，245，： | 1 |
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