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| 1 | 人类少突胶质细胞在髓鞘修复中的作用显示文摘有关髓鞘和少突胶质细胞的研究大部分与脱髓鞘疾病相关,如多发性硬化、脑白质营养不良或脊髓损伤。髓鞘慢性脱失,慢慢导致神经退行性变,最终导致永久而严重的神经功能丧失。因此,尽快恢复髓鞘是修复脱髓鞘疾病的最有效方法。移植外源性的髓鞘再生细胞是一个有希望的治疗方法。已有多项在体和离体实验将各种具有髓鞘形成功能细胞(少突胶质细胞、施万细胞、嗅鞘细胞等)进行移植,观察其髓鞘修复功能。本综述对将人类少突胶质细胞用于治疗脱髓鞘疾病的相关研究进行总结。首先,对人类少突胶质细胞从胚胎发育晚期到产后早期的发育过程进行简要的综述。然后,对各种内源性和外源性的少突胶质细胞调节因子的研究进行总结。在离体实验中,必须调控好各种调节因子才能使培养的少突胶质细胞达到足够的数量用于移植。之后,探讨了人类少突胶质细胞的可能来源,包括一些新型的少突胶质细胞生产策略,如诱导多能干细胞诱导直接分化为少突胶质细胞。最后,本综述对人类少突胶质细胞的髓鞘再生功能和效率进行了系统的回顾。 | Marcin Czepiel Erik Boddeke Sjef Copray 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，2： | 6 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Engineering fructan metabolism in plants显示文摘 | Tita R Sjef C M S | 2003 | Journal of Plant Physiology2003，160，7： | 1 |
| 4 | Glucose delays seed germination in Arabidopsis thaliana显示文摘 | Bas J. W. Dekkers Jolanda A. M. J. Schuurmans Sjef C. M. Smeekens | 2004 | Planta2004，，4： | 1 |
| 5 | Taxation and Foreign Direct Investment: A Synthesis of Empirical Research显示文摘 | Ruud A. de Mooij Sjef Ederveen | 2003 | International Tax and Public Finance2003，，6： | 1 |
| 6 | Sugar effects on early seedling development in Arabidopsis显示文摘 | Sara Rognoni Sheng Teng Laura Arru Sjef C. M. Smeekens Pierdomenico Perata | 2007 | Plant Growth Regulation2007，，3： | 1 |
| 7 | 中华祥云塔显示文摘作为2018 年哈尔滨国际冰雪建造节的主建筑物,中华祥云塔( 又名弗拉明戈塔) 由中荷师生团队联合设计并指导建造。项目于2018 年1 月10 日建成于哈尔滨市松北区,枫叶奥特莱斯小镇入口广场,以30.541m 的高度打破了国际冰壳21m 的原高度世界记录,创造了新的世界纪录,并被世界纪录认证机构现场认证。 | 罗鹏 阿尔诺·普隆克 李姣佼 袁路 王凯 Yaron Moonen 周轶玲 Sjef Brands Rijk Blok | 2019 | 建筑实践2019，2，11： | 1 |
| 8 | Advance Directives in Psychiatry 显示文摘 | Sjef G | 2014 | Intemational of Ethics Law and the New Medicine2014，54，： | 1 |
| 9 | Contraction - Induced Muscle Fiber Damage Is Increased in Soleus Muscle of Streptozotocin- Diabetic Rats and Is Associated with Elevated Expression of Brain - Derived Neurotrophic Factor mRNA in Muscle Fibers and Activated Satellite Cells 显示文摘 | Sjef Copray Robert Liem Nieske Brouwer | 2000 | Experimental Neurology2000，161，： | 1 |
| 10 | Advance directives in Psychia- try 显示文摘 | SJEF gevers | 2002 | European Journal of Health Law2002，9，： | 1 |
| 11 | Advance directives in psychiatry显示文摘 | Sjef Gevers | 2002 | European Journal of Health Law2002，，9： | 1 |
| 12 | The performance advantages of a dual stage system 显示文摘 | MARC B VAN DE COEN V SJEF T | 2004 | Proceedings of SPIE2004，53，77： | 1 |
| 13 | Degradation of macrolide antibiotics by ozone:A mechanistic case study with clarithromycin显示文摘 | FRANZISKA L SJEF C DAVID K | 2006 | Chemosphere2006，65，： | 1 |
| 14 | Taxation and Foreign Direct Investment: A Synthesis of Empirical Research显示文摘 | Ruud A. de Mooij Sjef Ederveen | 2003 | International Tax and Public Finance2003，，6： | 1 |
| 15 | Assessing Non-Lethal Weapons Use in Detain- ee Operations in Iraq:Benign Force or Necessary Evil 显示文摘 | Sjef Orbons | 2012 | Defence Studies2012，12，3： | 1 |
| 16 | Clinical aspects,out-come assessment,and management of ankylosing spondylitis and posten-teric reactive arthritis显示文摘 | Van Der Linden Sjef MD Van Der Heijde | 2000 | Current Opinion in Rheumatology2000，122，： | 1 |
| 17 | Engineering fructan metabolism in plants 显示文摘 | Tita Ritsema Sjef C M Smeekens | 2003 | Journal of Plant Physiology2003，160，7： | 1 |
| 18 | Rulse for optimization of biooatalysis in organic solvents 显示文摘 | Colja L Sjef B Kees V | 1987 | Biotechnol Bioeng1987，30，1： | 1 |
| 19 | Rules for optimization of biocatalysis in organic solvents 显示文摘 | Colja Laane Sjef Boeren Kees Vos | | Biotechnology and Bioengineering0，30，： | 1 |
| 20 | Angioplasty for coarctation in different aged patients显示文摘 | Ronald J. Walhout Jaco C. Lekkerkerker Sjef M.P.G. Ernst Paul A. Hutter Thijs H.W.M. Plokker Erik J. Meijboom | 2002 | American Heart Journal2002，，1： | 1 |
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