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| 1 | 利用间歇浸没式生物反应器进行果蔗组培快繁显示文摘以果蔗(Badila)茎尖脱毒组培苗为材料,利用间歇浸没式生物反应器(Temporary immersion bioreactors TIBs)进行组培快繁的技术体系的研究。结果表明:(1)使用TIBs系统进行甘蔗组织培养一代增殖较传统方法高出10倍以上;(2)TIBs系统以第4代继代材料为宜;(3)接种密度在10~15株/L培养基最有利于甘蔗组培苗的增殖和生长;(4)TIBs系统中6-BA浓度为0.5~1.0mg/L时适合于增殖培养,NAA浓度为4mg/L时有利于根的诱导;(5)浸没间歇频率在1min/3h时增殖和生长表现较为优异,1min/6h时有利于根的诱导和根的生长。 | 杨柳 秦钢 杨丽涛 罗瑞鸿 游建华 Ariel D Arencibia 魏源文 李杨瑞 | 2010 | 热带作物学报2010，31，4： | 18 |
| 2 | Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver显示文摘AIM: To evaluate the in vivo effect of glutamine on cobaltgenerated oxidative stress and (HO-1) induction in rat liver.METHODS: Fasted female Wistar rats received a single injection of cobalt chloride (375 μmol/kg body weight) and then were killed at different times. Lipid peroxidation and soluble and enzymatic antioxidant defense system (reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)) were measured in liver homogenates. Ferritin and ferritin iron contents as well as heme oxygenase-1 (HO-1) activity and expression were also determined. The antioxidant properties of glutamine (Gin) were also evaluated. RESULTS: Cobalt chloride increased lipid peroxidation (50% over control values) 1 h after treatment. GSH reached a minimum at 3 h (40%) increasing thereafter. Twelve hours after CoCl2 injection, the antioxidant enzymes CAT, GSH-Px and SOD also diminished by about 30%. Heme oxygenase-1 induction was observed 6 h after treatment reaching a maximum value of 14-fold over the controls, 12 h after cobalt treatment. A 1.7-fold increase in ferritin and ferritin-bound iron 24 h after treatment were also obtained. Administration of glutamine (300 mg/kg body weight) by gavage 24 h before CoCl2 treatment entirely prevented the increase in thiobarbituric acid reactive substances (TBARS) content, the decrease in GSH levels, and partially reverted heme oxygenase-1 induction. CONCLUSION: These results suggested that a natural product such as glutamine prevents glutathione depletion and consequently heme oxygenase induction. | Soledad Gonzales Ariel H.Polizio María A.Erario María L.Tomaro | 2005 | World Journal of Gastroenterology2005，11，23： | 16 |
| 3 | From Yokohama to Sendai: Approaches to Participation in International Disaster Risk Reduction Frameworks显示文摘Taking the importance of local action as a starting point, this analysis traces the treatment of participation of local and community actors through the three international frameworks for disaster risk reduction(DRR): the Yokohama Strategy and Plan of Action for a Safer World, the Hyogo Framework for Action 2005–2015, and the Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR). The study finds a concerning shift away from valuing local community input and toward promoting technological advances. Community actors went from valued partners with their own expertise and relevant beliefs in Yokohama Strategy to ‘‘aid recipients’ ’ to whom tailored risk information must be transmitted(in SFDRR). This shift may reflect the top-down nature of negotiated international agreements or a broader shift toward investments in technological solutions. Whatever the cause, given widespread recognition of the importance of local knowledge and participation and growing recognition of the importance of intra-community differences in vulnerability, it suggests the need for reconsideration of both the discourse and the practice of involving community-level actors in DRR planning and implementation. | Arielle Tozier de la Poterie Marie-Ange Baudoin | 2015 | International Journal of Disaster Risk Science2015，6，2： | 16 |
| 4 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 13 |
| 5 | 树轮记录的自公元1200年以来强火山喷发事件与高亚洲南部河流源区气候水文变化的关联显示文摘强火山喷发作为气候变化重要的外强迫因素,其所造成的气候环境效应一直是气候变化研究热点,而其对于流域水循环影响较少受关注。本文利用采自高亚洲南部河流源区麦吊云杉(Picea brachytyla)树轮样本,研制出一个长达885 a的树木年轮标准宽度年表。基于树轮气候响应分析结果,利用线性回归模型重建研究区自公元1200年上年11月至当年2月平均最低气温变化,重建方程方差解释量47.1%。该气温重建序列显示,研究区自公元1200年经历了8个冷期和9个暖期,包含有10个极冷年和23个极暖年。同时,该气温重建序列验证了自公元1200年来27次强火山喷发(VEI≥5)对于青藏高原东南部河流源区气候的影响,包括1257年Samalas和1815年Tambora等强火山喷发事件。该气温重建序列与相关河流径流数据对比结果表明强火山喷发在引起高亚洲南部河流源区气温出现明显下降的同时,也可能会进一步导致水循环减缓,使得高亚洲南部河流径流量出现减少。 | 陈友平 陈峰 张合理 胡茂 王世杰 Hadad Martín ARIEL Roig Junent Fidel ALEJANDRO | 2021 | 第四纪研究2021，41，2： | 12 |
| 6 | The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold显示文摘Plant long noncoding RNAs(lncRNAs)have emerged as important regulators of chromatin dynamics,impacting on transcriptional programs leading to different developmental outputs.The lncRNA AUXIN-REGULATED PROMOTER LOOP(APOLO)directly recognizes multiple independent loci across the Arabidopsis genome and modulates their three-dimensional chromatin conformation,leading to transcriptional shifts.Here,we show that APOLO recognizes the locus encoding the root hair(RH)master regulator ROOT HAIR DEFECTIVE 6(RHD6)and controls RHD6 transcriptional activity,leading to cold-enhanced RH elongation through the consequent activation of the transcription factor gene RHD6-like RSL4.Furthermore,we demonstrate that APOLO interacts with the transcription factor WRKY42 and modulates its binding to the RHD6 promoter.WRKY42 is required for the activation of RHD6 by low temperatures and WRKY42 deregulation impairs cold-induced RH expansion.Collectively,our results indicate that a novel ribonucleoprotein complex with APOLO and WRKY42 forms a regulatory hub to activate RHD6 by shaping its epigenetic environment and integrate signals governing RH growth and development. | Michael Moison Javier Martinez Pacheco Leandro Lucero Camille Fonouni-Farde Johan Rodriguez-Melo Natanael Mansilla Aurelie Christ Jeremie Bazin Moussa Benhamed Fernando Ibanez Martin Crespi Jose M.Estevez Federico Ariel | 2021 | Molecular Plant2021，14，6： | 8 |
| 7 | Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon显示文摘When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products(DBPs) may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine(NDMA), may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment processes.The test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon(PAC) sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than67% ammonia and 70%–100% N-nitrosamine precursors were removed by Mordenite zeolite(except 3-(dimethylaminomethyl)indole(DMAI) and 4-dimethylaminoantipyrine(DMAP)). PAC effectively removed DMAI and DMAP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors(dimethylamine(DMA), ethylmethylamine(EMA), diethylamine(DEA), dipropylamine(DPA), trimethylamine(TMA), DMAP, and DMAI) during the alum coagulation process. | Runmiao Xue Ariel Donovan Haiting Zhang Yinfa Ma Craig Adams John Yang Bin Hua Enos Inniss Todd Eichholz Honglan Shi | 2018 | Journal of Environmental Sciences2018，30，2： | 7 |
| 8 | 岩石变形记忆效应:应用、试验与理论显示文摘基于岩石变形记忆效应DME&DRA法,为准确便捷测量初始地应力提供了全新的思路,国际上及中国台湾的一系列实践应用证明了其巨大的潜力。但是,岩石变形记忆效应的研究和工程应用在中国(除中国台湾外)刚起步,同时,试验及理论的系统性研究整体上落后于工程应用,成为制约DME&DRA法成熟和普及的瓶颈问题。因此,开展岩石变形记忆效应的应用、试验、理论的研究进展综述具有重要意义。首先给出岩石DME&DRA法的基本概念,然后给出在国际上的应用实践现状;从7个方面的内容对试验研究进展进行系统性评述:(1)岩石变形记忆DRA曲线特征;(2)岩石变形记忆效应的失忆性;(3)人工记忆与地应力记忆;(4)初始加载保持时间;(5)初始加载重复次数;(6)记忆存在应力区域;(7)三维应力记忆特征;详细探讨各方面成果及不足;探讨了岩石变形记忆效应形成机理的两种认识及相应的理论模型,深入剖析现有研究结论与进展揭示存在的挑战,最终给出研究方向与建议。为推动国内开始开展岩石变形记忆效应的研究与应用提供基础。 | 王海军 汤雷 任旭华 钟凌伟 司富安 HSIEH Ariel | 2018 | 岩土工程学报2018，40，9： | 6 |
| 9 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 10 | Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases显示文摘Fatty liver diseases,non-alcoholic fatty liver disease(NAFLD)and alcoholic liver disease(ALD)are the most common causes of chronic liver diseases around the world.NAFLD and ALD can progress towards a more severe form of the disease,including as non-alcoholic steatohepatitis(NASH)and alcoholic steatohepatitis(ASH).In both instances central pathogenic events include hepatocyte death,liver inflammation,pathological angiogenesis,and fibrosis,followed by cirrhosis and cancer.Over the last few years,extracellular vesicles(EVs)have been identified as effective cell-to-cell communicators that contain a cell-and stressspecific cargo from the cell of origin and are capable of transferring this cargo to a target or acceptor cell.In this review,we focus on the growing evidence supporting a role for EVs in the pathophysiology of NASH and ASH as well as their potential roles as targets for novel biomarkers for these conditions. | Akiko Eguchi Ariel E.Feldstein | 2018 | Liver Research2018，2，1： | 5 |
| 11 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 5 |
| 12 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 13 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Mustafa S. Ascha Ibrahim A. Hanouneh Rocio Lopez Tarek Abu‐Rajab Tamimi Ariel F. Feldstein Nizar N. Zein | 2010 | Hepatology2010，，6： | 4 |
| 14 | Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain显示文摘The central nervous system has a very high energy requirement.Accordingly,despite representing only 2%of the body’s mass,the brain uses20%of the total oxygen consumption.Importantly,because most of this energy is used to maintain synaptic activity,even a mild decrease in its supply to the brain has deleterious implications for synaptic function.For example,only one minute of interruption of the cerebral blood | ariel diaz manuel yepes | 2018 | Neural Regeneration Research2018，13，2： | 4 |
| 15 | Biomass and dominance of conservative species drive above-ground biomass productivity in a mediterranean-type forest of Chile显示文摘Background: Forest productivity has a pivotal role in human well-being. Vegetation quantity, niche complementarity, mass-ratio, and soil resources are alternative/complementary ecological mechanisms driving productivity. One challenge in current forest management depends on identifying and manipulating these mechanisms to enhance productivity. This study assessed the extent to which these mechanisms control aboveground biomass productivity(AGBP) of a Chilean mediterranean-type matorral. AGBP measured as tree aboveground biomass changes over a 7-years period, was estimated for twelve 25 m × 25 m plots across a wide range of matorral compositions and structures. Variables related to canopy structure, species and functional diversity, species and functional dominance, soil texture, soil water and soil nitrogen content were measured as surrogates of the four mechanisms proposed. Linear regression models were used to test the hypotheses. A multimodel inference based on the Akaike’s information criterion was used to select the best models explaining AGBP and for identifying the relative importance of each mechanism.Results: Vegetation quantity(tree density) and mass-ratio(relative biomass of Cryptocarya alba, a conservative species) were the strongest drivers increasing AGBP, while niche complementarity(richness species) and soil resources(sand, %) had a smaller effect either decreasing or increasing AGBP, respectively. This study provides the first assessment of alternative mechanisms driving AGBP in mediterranean forests of Chile. There is strong evidence suggesting that the vegetation quantity and mass-ratio mechanisms are key drivers of AGBP, such as in other tropical and temperate forests. However, in contrast with other studies from mediterranean-type forests, our results show a negative effect of species diversity and a small effect of soil resources on AGBP.Conclusion: AGBP in the Chilean matorral depends mainly on the vegetation quantity and mass-ratio mechanisms.The findings of this study have implications for matorral restoration and management for the production of timber and non-timber products and carbon sequestration. | Ariel Isaías Ayma-Romay Horacio E.Bown | 2019 | Forest Ecosystems2019，6，4： | 4 |
| 16 | The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study显示文摘 | Leon A. Adams James F. Lymp Jenny St. Sauver Schuyler O. Sanderson Keith D. Lindor Ariel Feldstein Paul Angulo | 2005 | Gastroenterology2005，，1： | 3 |
| 17 | Novel molecular targets in hepatocellular carcinoma显示文摘Globally,hepatocellular carcinoma(HCC)is a leading cause of cancer and cancerrelated deaths.The therapeutic efficacy of locoregional and systemic treatment in patients with advanced HCC remains low,which results in a poor prognosis.The development of sorafenib for the treatment of HCC has resulted in a new era of molecular targeted therapy for this disease.However,the median overall survival was reported to be barely higher in the sorafenib treatment group than in the control group.Hence,in this review we describe the importance of developing more effective targeted therapies for the management of advanced HCC.Recent investigations of molecular signaling pathways in several cancers have provided some insights into developing molecular therapies that target critical members of these signaling pathways.Proteins involved in the Hedgehog and Notch signaling pathways,Polo-like kinase 1,arginine,histone deacetylases and Glypican-3 can be potential targets in the treatment of HCC.Monotherapy has limited therapeutic efficacy due to the development of inhibitory feedback mechanisms and induction of chemoresistance.Thus,emphasis is now on the development of personalized and combination molecular targeted therapies that can serve as ideal therapeutic strategies for improved management of HCC. | Ariel Ka-Man Chow Simon Wing-Lung Yau Lui Ng | 2020 | World Journal of Clinical Oncology2020，11，8： | 3 |
| 18 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 19 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 20 | Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD显示文摘 | Angela Shannon Naim Alkhouri Christine Carter-Kent Lidia Monti Rita Devito Rocio Lopez Ariel E. Feldstein Valerio Nobili | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 3 |
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