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| 1 | N^6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development显示文摘N6-Methyladenosine(m6 A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6 A modification methyltransferase, demethylase and proteins that preferentially recognize m6 A modification as 'writers', 'erasers' and 'readers', respectively. Altered expression levels of the m6 A modification key regulators substantially affect their function, leading to significant phenotype changes in the cell and organism. Recent studies have proved that the m6 A modification plays significant roles in regulation of metabolism, stem cell self-renewal, and metastasis in a variety of human cancers. In this review, we describe the potential roles of m6 A modification in human cancers and summarize their underlying molecular mechanisms. Moreover, we will highlight potential therapeutic approaches by targeting the key m6 A modification regulators for cancer drug development.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhfvk5w5xfc9k96q90.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Yi Niu Arabella Wan Ziyou Lin Xiongbin Lu Guohui Wan | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 2 | Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology显示文摘BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver dysfunction.Liver dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 patients.AIM To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.METHODS The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed.Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways.The differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/C.Gene expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using qRT-PCR.RESULTS Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and HDGF.Concordantly,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and GPAM.Consequently,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification capacity.In correspondence with the RNA-seq data analysis,we observed a significant upregulation of DNAJB1 and HSP90AB1 as well as significant downregulation of CYP39A1 in the blood plasma of severe COVID-19 patients with liver dysfunction.CONCLUSION Severe COVID-19 patients appear to experience significant transcriptional shift that may ensue tissue remodeling,mitochondrial dysfunction and lower hepatic detoxification resulting in the clinically observed liver dysfunction. | Sarah Musa Hammoudeh Arabella Musa Hammoudeh Poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi | 2021 | World Journal of Gastroenterology2021，27，21： | 2 |
| 3 | Nutritional quality of organic foods: a systematic review 显示文摘 | Alan D D Sakhi K D Arabella H | 2009 | American Society forNutrition2009，90，1： | 1 |
| 4 | Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study显示文摘 | Lisa M. Pierce Shannon Baumann Michelle R. Rankin Richard M. Wasserman Arabella Biaggi Thomas J. Kuehl Kimberly W. Coates | 2007 | American Journal of Obstetrics and Gynecology2007，，1： | 1 |
| 5 | Nutritional quality of organic foods: a systematic review 显示文摘 | Alan D Dangour Sakhi K Dodhia Arabella Hayter | 2009 | Am J Clin Nut2009，，： | 1 |
| 6 | Patients with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity显示文摘 | Roberto Cauda Stephen K. Tyring Carlo E. Grossi Arabella B. Tilden Kenneth D. Hatch W. Mitchell Sams Samuel Baron Dr. Richard J. Whitley | 1987 | Journal of Clinical Immunology1987，，4： | 1 |
| 7 | Prevalence of Mycoplasma pneumoniae -associated respiratory tract infections in hospitalized children: results of a 4-year prospective study in Tunis显示文摘 | Arabella Touati Sabine Pereyre Asma Bouziri Wafa Achour Ammar Khaldi Najla Ben Jaballah Cécile Bébéar Assia Ben Hassen | 2010 | Diagnostic Microbiology & Infectious Disease2010，，2： | 1 |
| 8 | A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance显示文摘Lenvatinib,a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer,facing limitations due to drug resistance.Here,we applied a multidimensional,high-throughput screening platform comprising patient-derived resistant liver tumor cells(PDCs),organoids(PDOs),and xenografts(PDXs)to identify drug susceptibilities for conquering lenvatinib resistance in clinically relevant settings.Expansion and passaging of PDCs and PDOs from resistant patient liver tumors retained functional fidelity to lenvatinib treatment,expediting drug repurposing screens.Pharmacological screening identified romidepsin,YM155,apitolisib,NVP-TAE684 and dasatinib as potential antitumor agents in lenvatinib-resistant PDC and PDO models.Notably,romidepsin treatment enhanced antitumor response in syngeneic mouse models by triggering immunogenic tumor cell death and blocking the EGFR signaling pathway.A combination of romidepsin and immunotherapy achieved robust and synergistic antitumor effects against lenvatinib resistance in humanized immunocompetent PDX models.Collectively,our findings suggest that patient-derived liver cancer models effectively recapitulate lenvatinib resistance observed in clinical settings and expedite drug discovery for advanced liver cancer,providing a feasible multidimensional platform for personalized medicine. | Lei Sun Arabella H.Wan Shijia Yan Ruonian Liu Jiarui Li Zhuolong Zhou Ruirui Wu Dongshi Chen Xianzhang Bu Jingxing Ou Kai Li Xiongbin Lu Guohui Wan Zunfu Ke | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 9 | Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial显示文摘Background:Given the importance of flexible use of different COVID-19 vaccines within the same schedule to facilitate rapid deployment,we studied mixed priming schedules incorporating an adenoviral-vectored vaccine(ChAdOx1 nCoV-19[ChAd],AstraZeneca),two mRNA vaccines(BNT162b2[BNT],Pfizer-BioNTech,and mRNA-1273[m1273],Moderna)and a nanoparticle vaccine containing SARS-CoV-2 spike glycoprotein and Matrix-M adjuvant(NVX-CoV2373[NVX],Novavax). | Arabella S V Stuart | 2021 | 四川生理科学杂志2021，43，10： | 0 |
| 10 | 循环肿瘤细胞在结直肠癌免疫治疗中的应用前景显示文摘液体活检的概念在十多年前被提出后,很快就扩展到了循环肿瘤细胞(CTC)领域。CTC作为一种新型的生物标志物,具有无创、敏感、操作简易等传统影像学检测和活体检测无法比拟的优点,正成为日渐重要的肿瘤诊疗技术。CTC除了可以提供基因组层面的分析,还可以由此得到转录组、蛋白组及表观遗传组等层面的信息。相比其他液体活检技术,CTC检测能够提供更为完整的肿瘤遗传信息,以及展示出更为详细的肿瘤发展轨迹。针对微卫星不稳定型(MSI)结直肠癌,免疫疗法的预后最佳。CTC的检测对结直肠癌预后评估、个性化用药与制定免疫治疗方案有着重要的临床应用价值。本综述系统总结了CTC分离方法和在肿瘤中的应用,影响结直肠癌免疫疗效的预后因素,以及对如何利用CTC检测表征来制定治疗方案,动态检测疾病进展、判断预后、评价免疫疗效和精准治疗等展开了讨论和展望。 | WAN Arabella H 李佳蕊 信文君 万国辉 | 2022 | 药学学报2022，57，9： | 0 |
| 11 | Heritage Impact Assessment (HIA) as an Alternative Evaluation Tool for Historical Built Heritages in Lahore, Pakistan显示文摘Heritage Impact Assessments(HIAs)are progressively needed to investigate potential impacts and outcomes of development on the Outstanding Universal Value(OUV)of world heritage properties.However,many key stakeholders involved in implementing the World Heritage Convention lack the management system,methodological tools,and guidelines to conduct effective impact assessments in areas without these resources.The paper explores the successful utilization of the Heritage Impact Assessment(HIA)tool to address concerns raised by UNESCO and civil society.This occurred when the Punjab government initiated the Orange Line Metro Train Project(OLMT)near the World Heritage Shalimar Garden and other historic monuments in Lahore.The project aimed to meet the daily transportation needs of around 2.5 million commuters. | Rabia Khaskheli Weiping Zhang Hina Marvi Arabella Bhutto | 2023 | Journal of World Architecture2023，7，6： | 0 |
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