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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Melena:A rare complication of duodenal metastases from primary carcinoma of the lung显示文摘Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. These metastases are usually asymptomatic, but may present as perforation, obstruction, malabsorption, or hemorrhage. Hemorrhage as a first presentation of small bowel metastases is extremely rare and is related to very poor patient survival. We describe a case of a 61- year old patient with primary adenocarcinoma of the lung, presenting with melena as the first manifestation of small bowel metastasis. Both primary tumor and metastatic lesions were diagnosed almost simultaneously. Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumor involving the duodenum and the proximal jejunum. Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma, suggesting that small bowel metastases from primary carcinoma of the lung occur usually in patients with terminal disease and rarely produce symptoms. Gastrointestinal bleeding from metastatic small intestinal lesions should be included in the differential diagnosis of gastrointestinal blood loss in a patient with a known bronchogenic tumor. | Chrysoula Kostakou Lubna Khaldi Andrew Flossos Andreas N Kapsoritakis Spiros P Potamianos | 2007 | World Journal of Gastroenterology2007，13，8： | 2 |
| 3 | On signals compression by EMD 显示文摘 | Khaldi K Boudraa A O | 2012 | Electronics Letters2012，48，21： | 1 |
| 4 | High-frequency os- cillatory ventilation in pediatric patients with acute respirato- ry failure显示文摘 | Ben Jaballah N Khaldi A Mnif K | 2006 | Pediatr Crit Care Med2006，7，4： | 1 |
| 5 | Identification of foodborne bacteria by infrared spectroscopy using cellular fatty acid methyl esters显示文摘 | Whittaker P Mossoba MM Khaldi S Al | 2003 | J Microbiological Methods2003，55，3： | 1 |
| 6 | Mobilization and homing of bone marrow stromal cells in myocardial infarction显示文摘 | Bittira B Shum - Tim D Al - Khaldi A | 2003 | Eur J Cardiothorac Surg2003，24，3： | 1 |
| 7 | Tissue distribution, gen- der- and genotype-dependent expression of autophagy-related genes in avian species显示文摘 | Piekarski A Khaldi S Greene E | 2014 | PLoS One2014，9，11： | 1 |
| 8 | High-frequency oscillatory ventilation in term and near-term infants with acute respiratory failure: early rescue use显示文摘 | Ben JN Mnif K Khaldi A | 2006 | Am J Perinatol2006，23，7： | 1 |
| 9 | Audit of a diabetic health education program at a large Primary Health Care Center in Asia region 显示文摘 | Al- Khaldi YM Khan MY | 2000 | Saudi Med J2000，21，9： | 1 |
| 10 | Hemangiopericytoma in the central nervous system显示文摘 | A. Mekni J. Kourda I. Chelly L. Ferchichi K. Bellil K.B. Hammouda N. Kchir M. Zitouna M. Khaldi S. Haouet | 2008 | Neurochirurgie2008，，1： | 1 |
| 11 | Mechanical stimula- tion in the form of vibration prevents postmenopausal bone loss in ovariectomized rats 显示文摘 | Flieger J Karachalios T Khaldi L | 1998 | Calcif Tissue Int1998，63，6： | 1 |
| 12 | Audio Watermarking Via EMD显示文摘 | KHALDI K BOUDRAA A O | 2013 | IEEE Transactions on Auido Speech and Lan- guage Processing2013，21，3： | 1 |
| 13 | Morphometric changes in the epiphyseal plate of the growing and young adult male rat after long-term salmon calcitonin administration显示文摘 | Khaldi L Karachalios TH Galanos A | 2005 | Calcif Tissue Int2005，76，： | 1 |
| 14 | management of meconium aspira- tionsyndrome with high frequency oscillatory ventilation显示文摘 | Bouziri A Hamdi A Khaldi A | 2011 | La Tunis Med2011，89，7： | 1 |
| 15 | Postmortem findings in 22 victims due to two grain silo explosions in France 显示文摘 | Botti K Grosleron-Gros N Khaldi N | 2003 | J Forensic Sei2003，48，4： | 1 |
| 16 | Prognostic value of bax, bcl -2, and p53 staining in primary osteosarcoma显示文摘 | Kaseta MK Khaldi L Gomatos IP | 2008 | J Surg Oncol2008，97，3： | 1 |
| 17 | Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose显示文摘 | Khaldi MZ Guiot Y Gilon P | 2004 | Am J Physiol Endocrinol Metab2004，287，2： | 1 |
| 18 | High-frequency oscillatory ventilation in term and near-term infants with acute respiratory failure:early rescue use 显示文摘 | Ben Jaballah N Mnif K Khaldi A | 2006 | Am J Perinatol2006，23，7： | 1 |
| 19 | Comparison of cardiac output measurements between NICO and the pulmonary artery catheter during repeat surgery for total hip replacement 显示文摘 | Gueret G Kiss G Khaldi S | 2007 | Eur J Anaesthesiol2007，24，12： | 1 |
| 20 | High level of extracellular potassium and its correlates after severe head injury :relationship to high intracranial pressure显示文摘 | Reinert M Khaldi A Zauner A | 2000 | J Neurosurg2000，93，： | 1 |
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