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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | C:N:P stoichiometry and nutrient limitation of the soil microbial biomass in a grazed grassland site under experimental P limitation or exces显示文摘Introduction:The availability of essential nutrients,such as nitrogen(N)and phosphorus(P),can feedback on soil carbon(C)and the soil microbial biomass.Natural cycles can be supplemented by agricultural fertiliser addition,and we determined whether the stoichiometry and nutrient limitation of the microbial biomass could be affected by an unbalanced nutrient supply.Methods:Samples were taken from a long-term trial(in effect since 1968)with annual applications of 0,15 and 30 kg P ha^(−1) with constant N and potassium.Soil and microbial biomass CNP contents were measured and nutrient limitation assessed by substrate-induced respiration.Linear regression and discriminant analyses were used to identify the variables explaining nutrient limitation.Results:Soil and biomass CNP increased with increasing P fertiliser,and there was a significant,positive,correlation between microbial biomass P and biomass C,apart from at the highest level of P fertilisation when the microbial biomass was over-saturated with P.The molar ratios of C:N:P in the microbial biomass remained constant(homeostatic)despite large changes in the soil nutrient ratios.Microbial growth was generally limited by C and N,except in soil with no added P when C and P were the main limiting nutrients.C,N and P,however,did not explain all the growth limitation on the soils with no added P.Conclusions:Increased soil C and N were probably due to increased net primary production.Our results confirm that C:N:P ratios within the microbial biomass were constrained(i.e.homeostatic)under near optimum soil conditions.Soils with no added P were characterised by strong microbial P limitation and soils under high P by over-saturation of microorganisms with P.Relative changes in biomass C:P can be indicative of nutrient limitation within a site. | Bryan S Griffiths Annette Spilles Michael Bonkowski | 2012 | Ecological Processes2012，1，1： | 23 |
| 3 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 4 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 5 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 6 | Immunisation against PCV2 structural protein by DNA vaccination of mice显示文摘 | Ren S K Annette M B Tine H F | 2004 | Vaccine2004，22，： | 1 |
| 7 | In vitro flexibility of the cervical spine after ventral uneoh)raminotomy laboratory investigation显示文摘 | Kirsten S Annette K Christopher B | 2007 | Journal of Neurosurgery: Spine2007，，7： | 1 |
| 8 | TLRT/8 triggering exerts opposing effects in acute versus latent HIV infection显示文摘 | Erika S Annette A Helene J | 2006 | J Immunol2006，176，5： | 1 |
| 9 | Determinants of life quality in school-age children with cerebral palsy显示文摘 | Annette M Micbeal S Peter R etal | 2007 | Journal of Pediatrics2007，151，5： | 1 |
| 10 | A PhaseⅠ dose-escalation study of regorafenib (BAY 73-4506),an inhibitor of oncogenic,angiogenic,and stromal kinases,in patients with advanced solid tumors显示文摘 | Klaus M Annette F Simone S | | 0，，09： | 1 |
| 11 | Genital Tract Infections, Bacterial Vaginosis, HIV, and Reproductive Health Issues among Lima-Based Clandestine Female Sex Workers显示文摘 | M. E. Perla Annette E. Ghee Sixto Sánchez R. Scott McClelland Annette L. Fitzpatrick Luis Suárez-Ognio Javier R. Lama Jorge Sánchez Gregory T. Spear | 2012 | Infectious Diseases in Obstetrics and Gynecology2012，，： | 1 |
| 12 | Cognitive existential coupletherapy for newly diagnosed prostate cancer patients and their part-ners:A descriptive pilot study显示文摘 | Collins A L Bloch S Annette F | 2011 | Psycho-oncology2011，10，2： | 1 |
| 13 | Cheese flavour development by enzymatic conversions of peptides and amino acids显示文摘 | Gerrit S Annette V Eman A | 2000 | Food Research International2000，33，3： | 1 |
| 14 | Emerging group-A rotavirus and a nosocomial outbreak of diarrhoea显示文摘 | Marc-Alain Widdowson Gerard JJ van Doornum Wim HM van der Poel Annette S de Boer Ulrike Mahdi Marion Koopmans | 2000 | 2000 (9236)2000，，9236： | 1 |
| 15 | 显示文摘 | Michael N Annette B Olav S | 2005 | FEMS Microbiology Ecology2005，51，2： | 1 |
| 16 | Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer显示文摘 | Annette K. Larsen Aimery Gramont Virginie Poindessous Ana?s Bouygues Mériam Ayadi Paul Mésange | 2013 | Current Colorectal Cancer Reports2013，，3： | 1 |
| 17 | In vitro activities of terbinafine in combination with fluconazole,itraconazole,voriconazole,and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azole显示文摘 | Perea S Gonzalez G Annette W | 2002 | J Clin Microbiol2002，40，： | 1 |
| 18 | In vitro stabilizing effect of a transforaminal compared with two posterior lumbar interbody fusion cages显示文摘 | Annette K Werner S Erich K | 2005 | Spine2005，2，： | 1 |
| 19 | Dynamic cardiocirculatory control during propofol anesthesia in mechanically ventilated patients显示文摘 | Cornelius K Annette S Martin D | 2000 | Anesth Analg2000，91，5： | 1 |
| 20 | In vitro stabilizing effect of a trans- foraminal compared with two posterior lumbar interbody fusion cas- es 显示文摘 | Annette K Werner S Erich K | 2005 | Spine2005，22，30： | 1 |
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