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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini John | 2008 | Critical Care Medicine2008，，1： | 4 |
| 3 | Genetic algorithms for reliability-based optimization of water distribution systems显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simpson | 2005 | Journal of Water Resources and Management2005，26，6： | 1 |
| 4 | Cryoprecipitate for the correction of co- agulopathy associated with liver disease 显示文摘 | French C J Bellomo R Angus P | 2003 | Anaesth Intensive Care2003，31，4： | 1 |
| 5 | The acute dialysis qualify initiative: part II :patient selection for CRRT显示文摘 | Bellomo R Angus D Star RA | 2002 | Adv Ren Replace Ther2002，9，1： | 1 |
| 6 | Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase显示文摘 | Angus P Vaughan R Xiong S | 2003 | Gastroenterology2003，125，： | 1 |
| 7 | Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase显示文摘 | Angus P Vaughan R Xiong S | 2003 | Gastroenterology2003，125，： | 1 |
| 8 | Resistance to adefovir dipivoxil therapy associated with the seleetion of a novel muta- tion in the HBV polymerase 显示文摘 | Angus P Vaughan R Xiong S | 2003 | Gastroenterology2003，125，2： | 1 |
| 9 | Epidemiology of sepsis:unupdate显示文摘 | Angus D C Wax R S | 2001 | Crit Care Med2001，29，： | 1 |
| 10 | Genetic algorithms for reliability2based optimization of waterdistribution systems 显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simp son | 2004 | Journal of Water Resources andM anagem ent2004，，： | 1 |
| 11 | Islet encapsulation:strategies to enhance islet cell functions显示文摘 | Beck J Angus R Madsen B | 2007 | Tissue Eng2007，13，： | 1 |
| 12 | An improved genetic algorithm for pipe network optimization显示文摘 | Graeme C Dandy Angus R Simpson Lanurence J Murphy | 1996 | Water Resources Research1996，32，2： | 1 |
| 13 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 14 | RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients:a cohort analysis显示文摘 | Hoste EA Clermont G Kersten A Venkataraman R Angus DC De Bacquer D | | 0，，： | 1 |
| 15 | Diversity peaks at intermediate productivity in a laboratory micro- cosm 显示文摘 | KASSEN R ANGUS B GRAHAM B | 2000 | Nature2000，406，6795： | 1 |
| 16 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 17 | Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation显示文摘 | Vaughan R B Angus P W Chin Dusting J P F | 2003 | Gut2003，52，10： | 1 |
| 18 | Application of two ant colony optimisation algorithms to water distribution system optimization显示文摘 | ANGUS R S | 2006 | Mathematical and Computer Modelling2006，44，5： | 1 |
| 19 | Lay- er-by-layer engineered capsules and their applications 显示文摘 | ANGUS P R J CHRISTINA C ALEXANDRA S A | 2006 | Curr Opin Colloidln2006，11，4： | 1 |
| 20 | Diversity peaks at intermediate productivity in a laboratory microcosm显示文摘 | Kassen R Angus B Graham B | 2000 | Nature2000，406，： | 1 |
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