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| 1 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 2 | Post-licensure safety surveillance for human papillomavirus- 16/18-AS04- adjuvanted vaccine: more than 4 years of experience 显示文摘 | Angelo MG Zima J Tavares Da Silva F | 2014 | Pharmacoepidemiol Drug Saf2014，23，5： | 1 |
| 3 | Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database显示文摘AIM To evaluate the occurrence of resistant mutations in treatment-na?ve hepatitis C virus(HCV) sequences deposited in the European hepatitis C virus database(euH CVdb). METHODS The sequences were downloaded from the eu HCVdb(http://gffzzc7adb7d73a2545c0sqbwn6609o9no65xb.ffgz.tsg.suse.edu.cn/eu HCVdb/). The search was performed for full-length NS3 protease, NS5 A and NS5 B polymerase sequences of HCV, separated by genotypes 1a, 1b, 2a, 2b and 3a, and resulted in 798 NS3, 708 NS5 A and 535 NS5 B sequences from HCV genotypes1a, 1b, 2a, 2b and 3a, after the exclusion of sequences containing errors and/or gaps or incomplete sequences, and sequences from patients previously treated with direct antiviral agents(DAA). The sequence alignment was performed with MEGA 6.06 MAC and the resulting protein sequences were then analyzed using the BioE dit 7.2.5. for mutations associated with resistance. Only positions that have been described as being associated with failure in treatment in in vivo studies, and/or as conferring a more than 2-fold change in replication in comparison to the wildtype reference strain in in vitro phenotypic assays were included in the analysis.RESULTS The Q80 K variant in the NS3 gene was the most prevalent mutation, being found in 44.66% of subtype 1a and 0.25% of subtype 1b. Other frequent mutations observed in more than 2% of the NS3 sequences were: I170V(3.21%) in genotype 1a, and Y56F(15.93%), V132I(23.28%) and I170V(65.20%) in genotype 1b. For the NS5 A, 2.21% of the genotype 1a sequences have the P58 S mutation, 5.95% of genotype 1b sequences have the R30 Q mutation, 15.79% of subtypes 2a sequences have the Q30 R mutation, 23.08% of subtype 2b sequences have a L31 M mutation, and in subtype 3a sequences, 23.08% have the M31 L resistant variants. For the NS5 B, the V321 L RAV was identified in 0.60% of genotype 1a and in 0.32% of genotype 1b sequences, and the N142 T variant was observed in 0.32% of subtype 1b sequences. The C316 Y, S556 G, D559 N RAV were identified in 0.33%, 7.82% and 0.32% of genotype 1b sequences, respectively, and were not observed in other genotypes.CONCLUSION HCV mutants resistant to DAAs are found in low frequency, nevertheless they could be selected and therapy could fail due resistance substitutions in HCV genome. | Dimas Alexandre Kliemann Cristiane Valle Tovo Ana Beatriz Gorini da Veiga Angelo Alves de Mattos Charles Wood | 2016 | World Journal of Gastroenterology2016，22，40： | 1 |
| 4 | Post-licensure safety surveillance for human papillomavirus-16/18-AS04-adjuvanted vaccine: more than 4 years of experience 显示文摘 | Angelo MG Zima J Tavares Da Silva F | 2014 | Pharmacoepidemiol Drug Saf2014，23，5： | 1 |
| 5 | A versatile synthetic methodology for the synthesis of tryptophols显示文摘 | Simon J Garden Rosangela B da Silva Angelo C Pinto | 2002 | Tetrahedron2002，，42： | 1 |
| 6 | Interleukin-6 promoter polymorphisms -174 G/C in Brazilian patients with systemic lupus erythematosus显示文摘 | Asano NM Angelo HD da Silva HA | 2013 | Human Immunol2013，74，9： | 1 |
| 7 | A versatile synthetic methodology for the synthesis of tryptophols显示文摘 | Simon J G Rosangela B da S Angelo C P | 2002 | Tetrahedron2002，58，42： | 1 |
| 8 | The effect of acidification rate, pH and ageing time on the acidiccold set gelation of whey proteins显示文摘 | Angelo Luiz Fazani Cavallieri Rosiane Lopes da Cunha | 2008 | Food Hydrocolloids2008，22，： | 1 |
| 9 | Ophthalmologic findings in a large pedigree of 11778/Haplogroup J Leber hereditary optic neuropathy显示文摘 | Federico Sadun Anna Maria De Negri Valerio Carelli Solange R. Salomao Adriana Berezovsky Rafael Andrade Milton Moraes Angelo Passos Rubens Belfort Arlon Bastos Da Rosa Peter Quiros Alfredo A. Sadun | 2003 | American Journal of Ophthalmology2003，，： | 1 |
| 10 | IGF-2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil显示文摘 | de Maseena Diniz Maia P F da Silva T M Angelo H D | 2013 | J Matern Fetal Neonatal Med2013，26，3： | 1 |
| 11 | A versatile synthetic methodology for the synthesis of tryptophots[J1显示文摘 | Simon J G Rosangela B da S Angelo C P | | 0，，42： | 1 |
| 12 | The effects of acidification rate,pH and ageing time on the acidic cold set gelation of whey proteins显示文摘 | Angelo Luiz Fazani Cavallieri Rosiane Lopes da Cunha | 2008 | Food Hydroeolloids2008，22，： | 1 |
| 13 | The red blood cell protome and interactome: An update 显示文摘 | Angelo DA Pier GR Lello Z | 2010 | J Proteome Res2010，9，： | 1 |
| 14 | Analysis of a Concrete Structure that Was Exposed to Fires in the Metropolitan Region of Recife显示文摘 | Romildo Alves Berenguer Adauto de Holanda Barbosa Eliana Cristina Barreto Monteiro Romilde Almeidade Oliveira Angelo Just da Costa e Silva | 2016 | Journal of Civil Engineering and Architecture2016，10，3： | 0 |
| 15 | Relationship between phase angle,steatosis,and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus显示文摘BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous treatment.Such a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular carcinoma.Notably,a low phase angle(PA),evaluated by bioelectrical impedance analysis(BIA),is an independent prognostic marker of clinical progression and survival in HIV-infected patients.AIM To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus(HCV)-coinfected patients.METHODS A retrospective observational study by convenience sampling of coinfected HIV/HCV patients,in which all patients underwent transient elastography(Fibroscan)and BIA evaluation.Student’s t test was used for group comparisons,and Spearman’s or Pearson’s correlation test was used when appropriate.The significance level was set at 5%,and analyses were performed using SPSS version 21.0.RESULTS Forty-three patients who received antiretroviral therapy met the inclusion criteria,and 23(53.5%)were under treatment with protease inhibitors(PIs).There was no difference in PA between those who used PIs and those who did not(P=0.635).There was no correlation between fibrosis grade and PA(P=0.355)or lean mass(P=0.378).There was a significant inverse correlation between the controlled attenuation parameter(CAP)and lean mass(P=0.378),positive correlation between PA and lean mass(P=0.378),and negative correlation between PA and fatty mass(P=0.378),although the CAP and PA were not correlated.When evaluated by sex,no significant correlations were found.CONCLUSION PA determines the muscle function of HIV/HCV-coinfected patients,and the CAP values reinforce the association with lean mass,suggesting that patients require early nutritional interventions. | Sabrina Alves Fernandes Cristiane Valle Tovo AndréLuiz Machado da Silva Letícia Pereira Pinto Randhall B Carteri Angelo A Mattos | 2022 | World Journal of Hepatology2022，14，6： | 0 |
| 16 | Advances in cellular technology in the hematology field: What have we learned so far?显示文摘Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-theart concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research. | Gustavo Torres de Souza Claudineia Pereira Maranduba Camila Maurmann de Souza Danielle Luciana Aurora Soares do Amaral Francisco Carlos da Guia Rafaella de Souza Salomao Zanette Joao Vitor Paes Rettore Natana Chaves Rabelo Lucas Mendes Nascimento Icaro Franca Navarro Pinto Julia Boechat Farani Abrahao Elias Hallack Neto Fernando de Sa Silva Carlos Magno da Costa Maranduba Angelo Atalla | 2015 | World Journal of Stem Cells2015，7，1： | 0 |
| 17 | Performance of the Multiprofessional Team in Cytoreductive Surgeries with Intraperitoneal Hyperthermic Chemotherapy:Experience Reporting显示文摘Purpose:This study aims at reporting the experience of a cancer hospital’s multiprofessional team with surgery patients in performing cytoreductive surgeries associated with hyperthermic intraperitoneal chemotherapy.Methods:It is a reporting about the experience of the multiprofessional team at AC Camargo Cancer Center’s surgery center,which operates in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,thus guaranteeing the surgery patient’s safety.Results:No safety report for the surgery patient subjected to intraperitoneal hypothermic chemotherapy was found in the literature.Therefore,the surgery center’s multiprofessional team’s practice was based on standards for manipulating chemotherapeutic agents and for safely administering medication.A checklist was elaborated for cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy based on the surgery patient safety protocol and the institution’s multiprofessional team’s experience.Conclusions:From the multiprofessional team’s experiences in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,the importance of elaborating a checklist to promote the quality of assistance and guarantee patient safety during the entire intraoperative phase became evident. | Cecília da Silva Angelo(RN) Ademar Lopes(PhD) Catharina Ferreira de Meira Pachioni(MSc) Eduardo Henrique Giroud Joaquim(MSc) Samuel Aguiar Junior(PhD) Gustavo Cardoso Guimaraes(PhD) Glauco Baiocchi Neto(PhD) Felipe JoséFernandez Coimbra(PhD) Isabel Miranda Bonfim(MSc) Rita de Cassia Burgos de Oliveira(PhD) Tailine Ligia Tadini(RN) | 2018 | Journal of Pharmacy and Pharmacology2018，6，11： | 0 |
| 18 | Comparative Evaluation of Peptidases Produced by Penicillium corylophilum and Penicillium waksmanii in Solid State Fermentation Using Agro-industrial Residues显示文摘 | Ronivaldo Rodrigues da Silva Tamara Angelo Hamilton Cabral | 2013 | Journal of Agricultural Science and Technology(B)2013，3，3： | 0 |
| 19 | Comparing K-Means and Mean Shift Algorithms Performance Using Mahout in a Private Cloud Environment显示文摘 | Paulo Muniz de Avila Roan Simoes da Silva Luiz Angelo Valota Francisco Rodrigo Palucci Pantoni David Buzatto Sergio Donizetti Zorzo | 2014 | 通讯和计算机(中英文版)2014，11，1： | 0 |
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