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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis显示文摘 | Erwan Guyot Angela Sutton Pierre Rufat Christelle Laguillier Abdellah Mansouri Richard Moreau Nathalie Ganne-Carrié Michel Beaugrand Nathalie Charnaux Jean-Claude Trinchet Pierre Nahon | 2012 | Journal of Hepatology2012，，： | 2 |
| 3 | Genetic risk markers for hepatocellular carcinoma in patients with alcoholic liver disease显示文摘 | Pierre Nahon Angela Sutton Marianne Ziol Jessica Zucman-Rossi Jean-Claude Trinchet Nathalie Ganne-Carrié | 2015 | Hepat. Oncol2015，，1： | 1 |
| 4 | Lack of association of some chemokine system polymorphisms with the risks of death and hepatocellular carcinoma occurrence in patients with alcoholic cirrhosis: a prospective study显示文摘 | Pierre Nahon Angela Sutton Pierre Rufat Charles Faisant Chantal Simon Nathalie Barget Jean-Claude Trinchet Michel Beaugrand Liliane Gattegno Nathalie Charnaux | 2007 | European Journal of Gastroenterology & Hepatology2007，，5： | 1 |
| 5 | Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression显示文摘 | Hanna Hlawaty Nadine Suffee Angela Sutton Olivier Oudar Oualid Haddad Veronique Ollivier Christelle Laguillier-Morizot Liliane Gattegno Didier Letourneur Nathalie Charnaux | 2010 | Biochemical Pharmacology2010，，： | 1 |
| 6 | Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis显示文摘AIM:To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 (SDF-1)/CXCL12 and Monocyte Chemotactic Protein-1 (MCP-1)/CCL2 , or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma (HCC) occurrence in hepatitis C virus (HCV)-infected patients. METHODS:SDF-1 3'A, MCP-1 (-2518) and CCR5-32 polymorphisms, SDF-1α, Regulated upon Activation Normal T cells Expressed and Secreted (RANTES)/CCL5 and MCP-1 serum levels were determined in 120 HCV-infected patients, included at time of cirrhosis diagnosis and prospectively followed-up. RESULTS:During follow-up, 23/120 (19.1%) patients died and 47/120 (39.1%) developed HCC. Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. The occurrence of death or HCC during follow-up was similar among carriers and noncarriers of each polymorphism. There was no association between the carriage of mutated alleles and chemokine serum levels and the latter were not associated with the risks of death or HCC. CONCLUSION:This study suggests the lack of association of SDF-1 3'A , MCP-1 (-2518) , CCR5-32 polymorphisms with death and HCC occurrence in cirrhotic HCV-infected patients. | Pierre Nahon Angela Sutton Pierre Rufat Chantal Simon Jean-Claude Trinchet Liliane Gattegno Michel Beaugrand Nathalie Charnaux | 2008 | World Journal of Gastroenterology2008，14，5： | 1 |
| 7 | Stromal Cell-Derlved Faetor-1/Chemokine (C-X-C Motif)Ligand 12 Stimulates Human Hepatoma Cell Growth,Migration, and Invasion显示文摘 | Angela Sutton Veronique Friand Severlne Brule-Dormeger | 2007 | Mol Cancer Bes2007，5，1： | 1 |
| 8 | Inhibition of microsomal triglyceride transfer protein: Another mechanism for drug-induced steatosis in mice显示文摘 | Philippe Lettéron Angela Sutton Abdellah Mansouri Bernard Fromenty Dominique Pessayre | 2003 | Hepatology2003，，1： | 1 |
| 9 | FPGA设计视时序为一切显示文摘当FPGA设计无法满足时序性能目标时,其原因可能并不明显。解决方案不仅取决于FPGA实现工具为满足时序要求而优化设计的能力,还取决于设计人员指定前方目标,诊断并隔离下游时序问题的能力。目前,设计人员掌握了一些使用技巧,可以帮助您设置时钟。通过Synopsys Synplify Premier等工具正确设置时序约束,然后调整参数,以满足赛灵思FPGA设计的性能目标。 | Angela Sutton Paul Owens | 2014 | 中国电子商情2014，，12： | 0 |
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