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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats显示文摘Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos(CPF) exposure in rats.Methods:Forty adult male Wistar rats divided into 4 groups of 10 animals were used for the study.Croup I received soya oil(2 mL/kg) while group II was administered with melatonin(0.5 mg/kg).Group III was administered CPF only(8.5 mg/kg l/10th of the LD50) while group Ⅳ was pretreated with melatonin(0.5 mg/kg) and then exposed to CPF(8.5 mg/kg),10 min later.The regimens were administered by gavage once daily for a period of 28 d.At the end of the exposure period, the rats were sacrificed and the testicular tissues and pituitary glands were evaluated for the malonaldehyde(MDA) concentration and activities of superoxide dismutase(SOD) and catalase(CAT).Results:CPF increased MDA concentrations and reduced the activities of SOD and CAT in the testes and pituitary gland.Melatonin pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT activities.Conclusions:the study showed that subacute CPF-induced oxidative stress in the testes and pituitary glands were alleviated by melatonin due to its antioxidant property. | Angela J Umosen Suleiman F Ambali Joseph O Ayo Bisala Mohammed Chidiebere Uchendu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 5 |
| 3 | A new efficient resveratr ol synthesis显示文摘 | MARCELLA G O MARRA C O ANGELA F | 2002 | Tetrahedron Letters2002，，43： | 1 |
| 4 | Closed suctioning of intubated neonates maintains better physiologic stability:a randomized trial显示文摘 | Angela K Susan B Sandra F | 2003 | J Perinatol2003，23，3： | 1 |
| 5 | Increase of nisin production by Lactococcus lactis in different media显示文摘 | Angela F J Moraes D Cholewa O | 2005 | Aft J Biotech2005，4，3： | 1 |
| 6 | Expression of Yes-associated Protein YAP incommon solid tumors显示文摘 | Angela A Steinhardt Mariana F et a1 | 2008 | Hum Pathol2008，39，11： | 1 |
| 7 | Effect of hydrostatic pressure of various magnitudes on osteoarthritic chondrocytes exposed to IL-1β显示文摘 | Antonella F Giulia C Angela P | | Indian Journal of Medical Research0，131，： | 1 |
| 8 | Flat pearl from biofabrication of organized composites on inorganic substrates显示文摘 | Angela M B | 1994 | Nature1994，37，1： | 1 |
| 9 | An assessment of the use of interphase FISH with chromosome special probes as an alterative to cytogenetics in prenatal diagnosis显示文摘 | ANGELA T A TSHERIFA A F PHILLIPA M K | 2000 | Prenat Diagn2000，20，： | 1 |
| 10 | Effect of hydrostatic pressure of various magnitudesosteoarthritic chondrocytes exposed to IL-lbate 显示文摘 | Antonella F Giulia C Angela P et al | 2010 | Indian J Med Res2010，132，： | 1 |
| 11 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 12 | Prevention and management of obesity(mature adoles- cents and adults)显示文摘 | Angela F | 2011 | Institute for Clinical Systems Improvement2011，4，： | 1 |
| 13 | Antimicrobial susceptibility, phage types, and pulsetypes of Salmonella typhimurium, in Sao Paulo, Brazil 显示文摘 | ANGELA C R G AANTT SUELI A F | 2006 | Mem Inst Oswaldo Cruz Rio de Janeiro2006，101，3： | 1 |
| 14 | Some characteristics of Botrytis cinerea isolates tolerent to procymidone显示文摘 | Angela A Sagasta E M | 1986 | Plant Pathol1986，35，： | 1 |
| 15 | Teacher-Stydent Interaction and Gifted Studentsy AttitudesToward Chemistry in Laboratory Classroom in Singapore 显示文摘 | Quek Ghoon Lang Wong Angela F L Fraser Barry J | 2005 | The Journal of Classroom Interaction2005，，： | 1 |
| 16 | Functional asymmetry of human prefrontal cortex: encoding and retrieval of verbally and nonverbally coded information 显示文摘 | Bertram O Axel M Angela D F | 2000 | Journal of Cognitive Neuroscience2000，12，： | 1 |
| 17 | Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path显示文摘 | Copani A Angela Sortino M Nicoletti F | | 0，，： | 1 |
| 18 | Nothing but skin and bone显示文摘 | Patrick Ross F Angela MC | 2006 | Clin Invest2006，15，： | 1 |
| 19 | Iron deficiency in infancy and mother-child interaction at 5 years显示文摘 | CORAPCI F ANGELA E R LOZOFF B | 2006 | Dev Behav Pediatr2006，27，5： | 1 |
| 20 | Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence 显示文摘 | Biet F Angela de Melo Marques M Grayon M | 2007 | Microbes Infect2007，9，2： | 1 |
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