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| 1 | Management of ruptured hepatocellular carcinoma:Implications for therapy显示文摘AIM:To assess the treatment and tumor-related variables associated with outcome after treatment of spontaneously ruptured hepatocellular carcinoma (HCC).METHODS: Patients with ruptured HCC were identif ied. The complications, mortality and survival were assessed. The relationship between tumor size and the severity of hemoperitoneum and between tumor size and grade were examined.RESULTS: From January 1993 to January 2008, 556 patients with HCC with or without cirrhosis were evaluated; of which, 16 (2.87%) presented with spontaneous rupture. All but 1 patient had cirrhosis. Twelve patients underwent surgical resection while 4 underwent trans-cutaneous arterial catheter embolization (TAE) (trans-cutaneous arterial embolization). Early mortality (<30 d) was 25% (4 of 16) and was inversely relatedto Child-Pugh score; 3 of the 4 early deaths occurred in patients treated with TAE with 1 of 12 occurring in the resected group. There was no correlation between tumor size and grade or between size and severity of hemoperitoneum.CONCLUSION: Tumor size did not correlate with severity of the hemoperitoneum. There was an inverse relationship between G1-G3 (grade of cellular differentiation) HCC and dimensions. | Nicolò Bassi Ezio Caratozzolo Luca Bonariol Cesare Ruffolo Alessio Bridda Luigi Padoan Michele Antoniutti Marco Massani | 2010 | World Journal of Gastroenterology2010，16，10： | 26 |
| 2 | Acute appendicitis: What is the gold standard of treatment?显示文摘McBurney’s procedure represented the gold-standard for acute appendicitis until 1981,but nowadays the number of laparoscopic appendectomies has progressively increased since it has been demonstrated to be a safe procedure,with excellent cosmetic results and it also allows a shorter hospitalization,a quicker and less painful postoperative recovery.The aim of this editorial was to perform a review of the literature in order to address controversial issues in the treatment of acute appendicitis. | Cesare Ruffolo Alain Fiorot Giulia Pagura Michele Antoniutti Marco Massani Ezio Caratozzolo Luca Bonariol Francesco Calia di Pinto Nicolò Bassi | 2013 | World Journal of Gastroenterology2013，19，47： | 8 |
| 3 | Perianal Crohn's disease: Is there something new?显示文摘Perianal lesions are common in patients with Crohn's disease, and display aggressive behavior in some cases. An accurate diagnosis is necessary for the optimal management of perianal lesions. Treatment of perianal Crohn's disease includes medical and/or surgical options. Recent discoveries in the pathogenesis of this disease have led to advances in medical and surgical therapy with good results. Perianal lesions in Crohn's disease remain a challenging aspect for both gastroenterologists and surgeons and lead to a greatly impaired quality of life for all patients affected by this disease. A multidisciplinary approach is mandatory to obtain the best results. | Cesare Ruffolo Marilisa Citton Marco Scarpa Imerio Angriman Marco Massani Ezio Caratozzolo Nicolò Bassi | 2011 | World Journal of Gastroenterology2011，17，15： | 3 |
| 4 | Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol显示文摘 | Tian-Li Yue Xin-Liang Ma Xinkang Wang Anne M. Romanic Gao-lin Liu Calvert Louden Juan-Li Gu Sanjay Kumar George Poste Robert R. Ruffolo Giora Z. Feuerstein | 1998 | Circulation Research1998，，2： | 2 |
| 5 | Recent oboervations with β - adrenoceptor blockade显示文摘 | Ruffolo RR Jr Feueratein GZ Ohlstein EH | 1998 | Am J Hyper1998，11，1： | 1 |
| 6 | Clear cell sarcoma of the ileum: report of a case and review of the literature 显示文摘 | D'Amico FE Ruffolo C Romeo S | 2012 | Int J Surg Pathol2012，20，4： | 1 |
| 7 | Carvedilol, a new vasodilating beta-blocker with the potential for cardiovascular organ protection显示文摘 | Feuerstein GZ Ruffolo RR Jr | 1996 | Eur Heart J1996，17，： | 1 |
| 8 | A Methodology to Evaluate the Organizational Impact of It on Knowledge Management: An Italian Case Study显示文摘 | Grimaldi M Rippa P Ruffolo M | 2008 | Journal of Information Technology Case and Application Research2008，，2： | 1 |
| 9 | Pharmacology of carvedilol:rationale for use in hypertension, coronary artery disease,and congestive heart failure 显示文摘 | Ruffolo R R Feuerstein G Z | 1997 | Cardiovasc Drugs Ther1997，11，1： | 1 |
| 10 | Complications of high- energy bicondylar tibial plateau fractures treated with dual plating through 2 incisions 显示文摘 | Ruffolo MR Gettys FK Montijo HE | 2015 | J Orthop Trauma2015，29，2： | 1 |
| 11 | Carvedilol,a novel vasodilating beta-blocker with the potential for cardiovascular organ protection显示文摘 | Feuerstein GZ Ruffolo RR | 1996 | Eur Heart J1996，17，： | 1 |
| 12 | Protective effects of carvedilol in the myocardium 显示文摘 | Feuerstein G Z Bril A Ruffolo RR | 1997 | Am J Cardiol1997，80，11： | 1 |
| 13 | Toxoplasma gondii in fresh pork sausage and seroprevalence in butchers from factories in Londrina,Paraná State,Brazil显示文摘 | Dias R A Navarro I T Ruffolo B B | 2005 | Rev Inst Med Trop Sao Paulo2005，47，4： | 1 |
| 14 | Pharmacology of eprosartan:an angiotensin Ⅱ receptor antagonist,exploring hypotheses from clinical data显示文摘 | Ohlstein E H Ruffolo R R | 1999 | Am Heart J1999，138，32： | 1 |
| 15 | Carvedilol,a novel vasodilating beta-blocker with the potential for cardiovascular organ protection显示文摘 | Ruffolo RR Jr | 1996 | Eur Heart J1996，17，： | 1 |
| 16 | 显示文摘 | Ruffolo SC | 2003 | J Biol Chem2003，278，25： | 1 |
| 17 | Parmacology of carvediol : rationatle for use in hepertension, coronary artery disease, and congestive heart failure 显示文摘 | Ruffolo Jr Feuerstein GZ | 1997 | Cardiovasc Drugs Ther1997，11，： | 1 |
| 18 | Pharmacology of Carvedilol: rationale f or use in hypertension, coronary artery disease,and congestive heart failure显示文摘 | Ruffolo RR Jr Feuerstein GZ | 1997 | Cardiovasc Drugs Ther1997，，1： | 1 |
| 19 | The interaction of the enantiomers of carvedilol with alpha 1-and beta 1-adrenoceptors显示文摘 | Nichols AJ Sulpizio AC Ashton DJ Hieble JP Ruffolo RR Jr | 1989 | Chirality1989，1，： | 1 |
| 20 | Pharmocology of carvedilol:rationale for use in hypertesion,and coronary heart disease,and congestive heart failure显示文摘 | Ruffolo R R Feuerstein G Z | 1997 | Cardiovasc Drugs Ther1997，11，1： | 1 |
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