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| 1 | The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design显示文摘The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment. | Kamal Choudhary Kevin F.Garrity Andrew C.E.Reid Brian DeCost Adam J.Biacchi Angela R.Hight Walker Zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea Centrone Albert Davydov Jie Jiang Ruth Pachter Gowoon Cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule David Vanderbilt Karin Rabe Francesca Tavazza | 2020 | npj Computational Materials2020，，1： | 10 |
| 2 | The serrated pathway to colorectal carcinoma: current concepts and challenges显示文摘 | Mark Bettington Neal Walker Andrew Clouston Ian Brown Barbara Leggett Vicki Whitehall | 2013 | Histopathology2013，，3： | 6 |
| 3 | 大堡礁和大峡谷世界遗产区的适应性管理显示文摘关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。 | Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona Ariella Helfgott Heather Leslie Jon Norberg Magnus Nystrm Per Olsson Henrik sterblom Marten Scheffer Heidi Schuttenberg Robert S.Steneck Maria Teng Max Troell Brian Walker James Wilson Boris Worm 丁莉 | 2007 | AMBIO-人类环境杂志2007，36，B11： | 4 |
| 4 | Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement From the American Heart Association显示文摘 | Dudley J. Pennell James E. Udelson Andrew E. Arai Biykem Bozkurt Alan R. Cohen Renzo Galanello Timothy M. Hoffman Michael S. Kiernan Stamatios Lerakis Antonio Piga John B. Porter John Malcolm Walker John Wood | 2013 | Circulation2013，，3： | 3 |
| 5 | The Global Stratotype Section and Point (GSSP) for the base of the Holocene Series/Epoch (Quaternary System/Period) in the NGRIP ice core显示文摘 | Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar Konrad Hughen Peter Kershaw Bernd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob Schwander | 2008 | Episodes2008，31，2： | 3 |
| 6 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 7 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 8 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 9 | Beyond first-line chemotherapy for advanced pancreatic cancer:An expanding array of therapeutic options?显示文摘While an increasing number of therapeutic options are now available for the first-line treatment of locally advanced or metastatic pancreatic cancer,the optimal choice for treatment in the second-line setting and beyond is less well defined.A variety of cytotoxic agents,either alone or in combination,have been evaluated,although primarily in the context of small single-arm or retrospective studies.Most regimens have been associated with median progression-free survival rates in the range of 2-4 mo and overall survival rates between 4-8mo,highlighting the very poor prognosis of patients who are candidates for such treatment.Targeted therapies studied in this chemotherapy-refractory setting,meanwhile,have produced even worse efficacy results.In the current article,we review the clinical evidence for treatment of refractory disease,primarily in patients who have progressed on front-line gemcitabine-based chemotherapy.In the process,we highlight the limitations of the available data to date as well as some of the challenges in designing appropriate clinical trials in this salvage setting,including how to select an appropriate control arm given the absence of a wellestablished reference standard,and the importance of incorporating predictive biomarkers and quality of life measures whenever possible into study design. | Evan J Walker Andrew H Ko | 2014 | World Journal of Gastroenterology2014，20，9： | 2 |
| 10 | Critical Appraisal of the Diagnosis of the Sessile Serrated Adenoma显示文摘 | Mark Bettington Neal Walker Christophe Rosty Ian Brown Andrew Clouston Leesa Wockner Vicki Whitehall Barbara Leggett | 2014 | The American Journal of Surgical Pathology2014，，2： | 2 |
| 11 | 指导性集体锻炼对治疗中的早期乳腺癌妇女的益处:实用性随机对照试验显示文摘目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中177位完成6个月随访。干预与常规护理相对照,干预组予12周指导性集体锻炼加常规护理。主要结果评价癌症治疗功能评价(FACT)问卷、贝克抑郁问卷、正性和负性情绪量表、体重指数、7日体力活动回忆问卷、12分钟步行实验和肩关节活动度评估。结果对基线值、研究中心、基线治疗和参加干预试验时的年龄进行校正后,综合效应模型的评估结果(干预组减对照组)显示第12周时:12分钟步行距离为129米(95%可信区间83~176),1周的中等强度活动时间182分钟(75~289),肩关节活动度2.6(1.6~3.7),乳腺癌特定的生活质量量表2.5(1.0~3.9),正性情绪4.0(1.8~6.3)。初步结果未发现干预锻炼对生活质量综合量表(FACT-G)有影响。随访6个月后,大多数效果维持不变,并且在乳腺癌特定的生活质量上得到改善。尚未有不良反应的报道。结论在12周干预锻炼结束时以及6个月后,指导性集体锻炼均显示出机体功能和心理上的获益。因此临床医生应该鼓励患者活动,决策者们应该考虑把体育锻炼纳入到癌症康复服务中来。试验注册号当前对照试验 ISRCTN12587864[controlled-trial.com]。 | Nanette Mutrie Anna M Campbell Fiona Whyte Alex McConnachie Carol Emslie Laura Lee Nora Kearney Andrew Walker Diana Ritchie 方桦(译) 王燕(校) | 2007 | 英国医学杂志中文版2007，10，4： | 2 |
| 12 | Obesity and gender influence cortisol secretion and metabolism in man显示文摘 | Andrew R Phillips DI Walker BR | 1998 | J Clin Endocrinol Metab1998，83，5： | 1 |
| 13 | 显示文摘 | Phillips DI Walker BR | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 14 | Glucocorticoids and Insulin Resistance : Old Hormones, New Targets 显示文摘 | Andrews R C Walker B R | 1999 | Clin Sci1999，96，： | 1 |
| 15 | Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans显示文摘 | Serge Vulliemoz David W. Carmichael Karin Rosenkranz Beate Diehl Roman Rodionov Matthew C. Walker Andrew W. McEvoy Louis Lemieux | 2010 | Neuroimage2010，，1： | 1 |
| 16 | Agricultural Transformation and the Politics of Hydrology in Northern Thailand显示文摘 | Andrew Walker | 2003 | Development and Change2003，，5： | 1 |
| 17 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 18 | Percutaneous Pulmonary Valve Implantation: Impact of Evolving Technology and Learning Curve on Clinical Outcome显示文摘 | Philipp Lurz Louise Coats Sachin Khambadkone Johannes Nordmeyer Younes Boudjemline Silvia Schievano Vivek Muthurangu Twin Yen Lee Giovanni Parenzan Graham Derrick Seamus Cullen Fiona Walker Victor Tsang John Deanfield Andrew M. Taylor Philipp Bonhoeffer | 2008 | Circulation2008，，15： | 1 |
| 19 | Effects of the 11beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes显示文摘 | Andrews RC Rooyackers O Walker BR | 2003 | J Clin Endocrinol Metab2003，88，1： | 1 |
| 20 | Glucocorticoids and insulin resistance:old hormones,new targets显示文摘 | Andrews RC Walker BR | 1999 | Clin Sci (Lond)1999，96，5： | 1 |
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