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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Moderate drinking? Alcohol consumption significantly decreases neurogenesis in the adult hippocampus显示文摘 | Anderson ML Nokia MS Govindaraju KP | 2012 | Neuroscience2012，224，： | 1 |
| 3 | Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia显示文摘 | Gates GA Anderson ML Feeney MP | 2008 | Arch Otolaryngol Head Neck Surg2008，134，7： | 1 |
| 4 | Contribution of intraoperative enteroseopy in the mannagement of obscure gastrointestinal bleeding显示文摘 | Kendriek ML Buttar NS Anderson MA | 2001 | J Gastrointest Surg2001，5，2： | 1 |
| 5 | Increased atheroselerosis in myeloperoxidase - deficient mice 显示文摘 | Brennan ML Anderson MM shih DM | 2001 | Clin Invest2001，18，： | 1 |
| 6 | Comfort,satisfacdon,and anxiolysis in surgical patients using a patient adjustable comfort warming system:aprospective randomized clinical trial显示文摘 | Brien D Greenfield ML Anderson JE | 2010 | Perianesth Nurs2010，25，： | 1 |
| 7 | Intraosse- ous innervation of the human patella: a histologic study显示文摘 | Barton RS Ostrowski ML Anderson TD | 2007 | Am J Sports Med2007，35，2： | 1 |
| 8 | Differences in the pro- file, treatment, and prognosis of patients with cardiogenic shock by myocardial infarction classifieation a report from NCDR显示文摘 | Anderson ML Peterson ED Peng SA | 2013 | Circula- tion Cardiovascular Quality & Outcomes2013，6，6： | 1 |
| 9 | Heahhrelatedquality of life among long term survivors of stroke显示文摘 | Haekett ML DuncanJR Anderson CS | 2000 | Stroke2000，312，2： | 1 |
| 10 | Biochem显示文摘 | ML Wetlanfer DB Anal | | (67):4930，，67： | 1 |
| 11 | Weather-related mortality: how heat, cold, and heat waves affect mortality in the United States 显示文摘 | Anderson BG Bell ML | 2009 | Epidemiology2009，20，2： | 1 |
| 12 | Improved survival after stroke: Is admission to hospital the major explanation? Trend analyses of the Auckland Regional Community Stroke Studies 显示文摘 | Carter KN Anderson CS Hackett ML | 2007 | Cerebrovasc Dis2007，23，2： | 1 |
| 13 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 14 | Innate immunity modulates adipokines in humans显示文摘 | Anderson PD Mehta NN Wolfe ML | 2007 | J Clin Endocrinol Metab2007，92，6： | 1 |
| 15 | Varying levels of family history of breast cancer in relation to marnmographic breast density 显示文摘 | Crest AB Aiello EJ Anderson ML | 2006 | Cancer Causes Contr2006，17，6： | 1 |
| 16 | Central audito- ry dysfunction as a harbinger of Alzheimer dementia显示文摘 | Gates GA Anderson ML McCurry SM | 2011 | Arch Otolaryngol Head Neck Surg2011，137，： | 1 |
| 17 | Balance interventions for diabetic peripheral neuropathy:a systematic review显示文摘 | Ites KI Anderson EJ Cahill ML | | 0，，03： | 1 |
| 18 | Immune properties of human umbilical cord Wharton' s jelly-derived cells 显示文摘 | Weiss ML Anderson C Medieetty S | 2008 | Stem Cells2008，26，11： | 1 |
| 19 | Health outcomes l year after subarachnoid hemorrhage:an international population-based study显示文摘 | Anderson CS | 2000 | Neurology2000，55，： | 1 |
| 20 | Treatment of ocular toxocariasis with albendezole: a case report显示文摘 | Frazier M Anderson ML Sophocleous S | 2009 | Optometry2009，80，： | 1 |
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