|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Chinese NGOs in action against HIV/AIDS显示文摘Chinese nongovernmental organizations (NGOs) have played a significant role in the battle against AIDS in the People’s Republic of China. This article provides a brief overview of the structure of these organizations, as well as an analysis of their principle accomplishments. Of great significance in this analysis is the fact that Chinese NGOs have effectively dealt with many sensitive health education areas that government authorities have felt reluctant to handle directly. As such, they have provided an indispensable component in the HIV/AIDS prevention and control calculus on the mainland. | Hua XU Yi ZENG Allen F ANDERSON | 2005 | Cell Research2005，15，11： | 4 |
| 4 | 吉林省受艾滋病影响儿童青少年相关情况及关怀与支持活动调查显示文摘目的了解吉林省受艾滋病影响儿童青少年的家庭经济生活、心理、学习和医疗保健等方面情况,以及近年来对其开展的关怀支持活动效果,探讨有效措施和方法保证其健康成长。方法在两个感染者相对集中、属于艾滋病综合防治示范区的县区随机选取58名7.18岁受艾滋病影响儿童青少年进行调查。结果58名受艾滋病影响儿童青少年均生活在农村,父母双亡1人,单亡11人;父母均患有艾滋病9人,一方患有艾滋病37人。家庭年平均收人2400元,低于当地的平均收人水平(3000元)。45名(77.59%)在校学习。自述得知父母患有艾滋病后学习成绩没有发生变化25名(55.56%),学习成绩下降11名(24.44%),学习成绩不稳定6名(13.33%),学习成绩有所提高3名(6.67%)。19名(32.76%)存在心理压力。24人(41.38%)担心父母的病情,不愿让他人知道父母患有艾滋病。51人(87.93%)了解艾滋病预防知识。58名受艾滋病影响儿童青少年都希望没有歧视、平等的生活,能够得到基本的医疗保健。当地政府落实了国家“四免一关怀”政策,学校内外进行了反歧视教育、生活技能培训及关怀与支持活动。结论受艾滋病影响儿童青少年在生活、心理、学习、医疗保健方面需要社会的帮助,开展关怀与支持活动能够促进他们的健康成长。 | 侯祥 Allen F Anderson 孟向东 徐迪祥 李志和 Hillary E Anderson 张新刚 范吉祥 郎莹 张孝伟 臧力权 | 2006 | 中国卫生工程学2006，5，2： | 3 |
| 5 | Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction显示文摘 | Jeffrey L Anderson John F Carlquist Joseph B Muhlestein Benjamin D Horne Sidney P Elmer | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 6 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 7 | Molecular characterization of a protective outer membrane lipoprotein (OmlA)of from Actionbacillus pleuropneumoniae serotype 1 显示文摘 | Gerlach G F Anderson C Klashinsky S | 1993 | Infect Imumun1993，61，2： | 2 |
| 8 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 9 | Unfrozen water contents of submarine permafrost determined by nuclear magnetic resonance 显示文摘 | Tice A R Anderson D M Sterrett K F | 1981 | Engineering Geology1981，18，： | 2 |
| 10 | In formation hiding a survey 显示文摘 | Petitcolas F A P Anderson R J Kulm M G | 1999 | IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 11 | The characterization and comparative analysis of high-molecular-weight glutenin genes from genomes A and B of a hexaploid bread wheat显示文摘 | Anderson O D Greene F C | 1989 | Theor Appl Genet1989，77，： | 1 |
| 12 | Ecological interactions in agroforestry systems显示文摘 | ANDERSON L S SINCLAIR F L | 1993 | Agroforestry Abstract1993，6，： | 1 |
| 13 | A parameter optimization approach for the optimal control of large-scale musculoskeletal systems 显示文摘 | Pandy M G Anderson F C | 1992 | J Bio Eng Trans of the ASME1992，114，11： | 1 |
| 14 | Can stem cells cross lineage boundaries?显示文摘 | Anderson D J Gage F H Weissman I L | 2001 | Nat Med2001，7，： | 1 |
| 15 | Improved standing-wave-type sloshing absorber显示文摘 | Anderson J G Semereigil S E Turan O F | 2000 | Journal of Sound and Vibration2000，235，4： | 1 |
| 16 | Repression of choroidal neovascularization through actin cy-toskeleton pathways by microRNA-24 显示文摘 | Zhou Q Anderson C Zhang H Li X Inglis F Jayagopal A | 2014 | Mol Ther2014，22，2： | 1 |
| 17 | Culex flavivirus and West Nile virus mosquito coinfection and positive ecological associ- ation in Chicago, United States 显示文摘 | Newman CM Cerutti F Anderson TK | 2011 | Vector Borne Zoonotic Dis2011，11，8： | 1 |
| 18 | Factorial invariance of LibQUAL + as a measure of library service quality over time 显示文摘 | Lane F C Anderson B Ponce H F | 2012 | Library & Information Science Research2012，34，1： | 1 |
| 19 | Ultrastructural morphmetric analysis of BrucelIa abortus-infected trophoblasts in experimental placentitis显示文摘 | Anderson T D Cheville N F | 2006 | Pathol2006，124，： | 1 |
| 20 | Patterns of cancer inci-dence,mortality,and prevalence across five continents:defining priorities to reduce cancer disparities in different geographic regions of the world显示文摘 | Kamangar F Dores GM Anderson WF | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员