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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Characterization of the Topography and Wettability of English Weed Leaves and Biomimetic Replicas显示文摘 | Pedro Miguel Matos Pereira Ana Sofia Moita Gabriel Amaro Monteiro Duarte Miguel Franca Prazeres | 2014 | Journal of Bionic Engineering2014，11，3： | 5 |
| 3 | Osteoblasts are inherently programmed to repel sensory innervation显示文摘Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons.Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development.Yet,the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still limited.Here,we demonstrated that differentiation of human mesenchymal stem cells to osteoblasts leads to a marked impairment of their ability to promote axonal growth,evidenced under sensory neurons and osteoblastic-lineage cells crosstalk.The mechanisms by which osteoblast lineage cells provide this nonpermissive environment for axons include paracrine-induced repulsion and loss of neurotrophic factors expression.We identified a drastic reduction of NGF and BDNF production and stimulation of Sema3A,Wnt4;and Shh expression culminating at late stage of OB differentiation.We noted a correlation between Shh expression profile,OB differentiation stages,and OB-mediated axonal repulsion.Blockade of Shh activity and signaling reversed the repulsive action of osteoblasts on sensory axons.Finally,to strengthen our model,we localized the expression of Shh by osteoblasts in bone tissue.Overall,our findings provide evidence that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation,and highlight osteoblast-derived Shh as an essential player in this cue-induced regulation. | Luis Leitao Estrela Neto Francisco Conceicao Ana Monteiro Marina Couto Cecilia JAlves Daniela MSousa Meriem Lamghari | 2020 | Bone Research2020，8，3： | 4 |
| 4 | Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat显示文摘Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis(R. officinalis) in ethanol-induced gastric ulcer model in vivo.Methods: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were measured.Results: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of(140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis(50 mg/kg, p.o.), a significant inhibition of mucosal injury of(21.2 ± 7.1) mm2(84%inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes(superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition,lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole(28.5%),camphor(27.7%) and alpha-pinene(21.3%).Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis. | Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo Jose Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos Jose Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 5 | Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress显示文摘 | Ana Faria Rosário Monteiro Nuno Mateus Isabel Azevedo Concei??o Calhau | 2007 | European Journal of Nutrition2007，，5： | 1 |
| 6 | Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: A molecular mechanism of protection against TNBS-induced colitis in rats显示文摘 | Eduardo Augusto Rabelo Socca Anderson Luiz-Ferreira Felipe Meira de Faria Ana Cristina de Almeida Ricardo José Dunder Luis Paulo Manzo Alba Regina Monteiro Souza Brito | 2014 | Chemico-Biological Interactions2014，，： | 1 |
| 7 | Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model显示文摘 | Ana Beatriz Albino de Almeida Marina Sánchez-Hidalgo Antonio Ramón Martín Anderson Luiz-Ferreira José Roberto Trigo Wagner Vilegas Lourdes Campaner dos Santos Alba Regina Monteiro Souza-Brito Catalina Alarcón de la Lastra | 2013 | Journal of Ethnopharmacology2013，，1： | 1 |
| 8 | Emission factors and detailed chemical composition of smoke particles from the 2010 wildfire season显示文摘 | Ana Vicente Célia Alves Ana I. Calvo Ana P. Fernandes Teresa Nunes Cristina Monteiro Susana Marta Almeida Casimiro Pio | 2013 | Atmospheric Environment2013，，： | 1 |
| 9 | Combining cover cropping with deficit irrigation in a Mediterranean low vigor vineyard显示文摘 | Carlos M. Lopes Tiago P. Santos Ana Monteiro M. Lucília Rodrigues Joaquim M. Costa M. Manuela Chaves | 2011 | Scientia Horticulturae2011，，4： | 1 |
| 10 | Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus , exposed to organophosphorus insecticide Folisuper 600 (methyl parathion)显示文摘 | Diana Amaral Monteiro Jeane Alves de Almeida Francisco Tadeu Rantin Ana Lúcia Kalinin | 2006 | Comparative Biochemistry and Physiology Part C2006，，2： | 1 |
| 11 | Organic speciation of aerosols from wildfires in central Portugal during summer 2009显示文摘 | Ana Vicente Célia Alves Cristina Monteiro Teresa Nunes Fátima Mirante Mário Cerqueira Ana Calvo Casimiro Pio | 2012 | Atmospheric Environment2012，，： | 1 |
| 12 | Measurement of trace gases and organic compounds in the smoke plume from a wildfire in Penedono (central Portugal)显示文摘 | Ana Vicente Célia Alves Cristina Monteiro Teresa Nunes Fátima Mirante Margarita Evtyugina Mário Cerqueira Casimiro Pio | 2011 | Atmospheric Environment2011，，29： | 1 |
| 13 | Monitoring Knitting Process Through Yarn Input Tension显示文摘 | Andre Catarino Ana Maria Rocha Joao Monteiro | 2003 | New Developments2003，25，6： | 1 |
| 14 | Monitoring knitting process through yarn input Tension 显示文摘 | Andre Catarino Ana Maria Rocha Joao Monteiro | 2003 | New Developments2003，25，6： | 1 |
| 15 | Influence of anthocyanins and derivative pigments from blueberry (Vaccinium myrtillus) extracts on MPP-I- intestinal uptake: A structure-activity approach 显示文摘 | ANA FARIA DIOGO PESTANA ROSIkRIO MONTEIRO | 2008 | Food Chemistry2008，109，3： | 1 |
| 16 | Static crystallization of zeolites MCM-22 and MCM-49 显示文摘 | Ana Lucia Santos Marques Jose Luiz Fontes Monteiro Helolse O Pastore | 1999 | Micropor Mesopor Mater1999，32，： | 1 |
| 17 | In vivo susceptibility to benznidazole of T rypanosoma cruzi strains from the western B razilian A mazon显示文摘 | Ana P. M. Teston Wuelton M. Monteiro Daniele Reis Gleison D. P. Bossolani M?nica L. Gomes Silvana M. Araújo Maria T. Bahia Maria G. V. Barbosa Max J. O. Toledo | 2012 | Trop Med Int Health2012，，： | 1 |
| 18 | BRCA1 regulates p53 -dependent gene expression显示文摘 | Ouchi T Monteiro ANA August A | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 19 | Severe hyponatremia in older patients at admission in an internal medicine department显示文摘 | Lurdes Correia Rogério Ferreira Inês Correia Ana Lebre José Carda Rita Monteiro Adélia Sim?o Armando Carvalho Nascimento Costa | 2014 | Archives of Gerontology and Geriatrics2014，，3： | 1 |
| 20 | Strategic Management of Design as Competitive Differential in Project Management: Scenario and Market Outlook in the Manaus City显示文摘 | Natasha Cristinne Alves Monteiro Armando Araujo de Souza Junior Luis Claiudio de Jesus-Silva Ana Flaivia de Moraes Moraes Luiz Augusto de Carvalho Francisco Soares Afranio de Amorim Francisco Soares Filho Sandro Breval Santiago | 2013 | China-USA Business Review2013，12，10： | 0 |
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