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| 1 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 2 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 3 | Design and discovery of materials guided by theory and computation显示文摘Computational materials science and engineering has emerged as an interdisciplinary subfield spanning materials science and engineering,condensed matter physics,chemistry,mechanics and engineering in general.Modern materials research often requires a close integration of computation and experiments in order to fundamentally understand the materials structures and properties and their relation to synthesis and processing.A number of computational methods and tools at different spatiotemporal scales are now well established,ranging from electronic structure calculations based on density functional theory,1,2 atomic molecular dynamics3,4 and Monte Carlo techniques,5 phase-field method6–9 to continuum macroscopic approaches.Over the last few years,computational materials activities have been steadily moving from technique development and purely computational studies of materials towards discovering and designing new materials guided by computation,machine learning and data mining or by a closely tied combination of computational predictions and experimental validation.This movement is being further accelerated by the recent initiatives by various government agencies in the United States,Europe,China and other countries to pursue the materials genome initiative,10 integrated computational materials engineering11–13 as well as the‘Big Data’initiative. | Long-Qing Chen Li-Dong Chen Sergei V Kalinin Gerhard Klimeck Sanat K Kumar Jörg Neugebauer Ichiro Terasaki | 2015 | npj Computational Materials2015，，1： | 2 |
| 4 | On the Mechanism of Intergranular Corrosion of Aluminum Alloys显示文摘 | V. S. Sinyavskii V. V. Ulanova V. D. Kalinin | 2004 | Protection of Metals2004，，5： | 2 |
| 5 | Posterobasal left ventricular aneurysm after myocardial infarction with normal coronary arteries:Case-report显示文摘We present a case of a 64-year-old woman with signs of debilitating condition including anginal chest pain, exertional dyspnea, and depression. The patient had previously suffered from a myocardial infarction after a loss of a close family member. Workup showed a posterobasal left ventricular aneurysm and moderate to severe mitral regurgitation in the absence of coronary atherosclerosis. Routine ultrasonography revealed abdominal aortic aneurysm and intraabdominal aortic deviation. The patient was immediately started on optimal medical treatment. On repeat assessment general condition was satisfactory, vital signs were normal, and investigations showed no signs of progressive heart failure or other significant clinical changes. Although prognosis in patients with myocardial infarction with normal coronary arteries is generally considered favorable, mechanical complications such as posterobasal left ventricular aneurysm with moderate to severe mitral regurgitation are possible. | Roman Evgenyevich Kalinin Igor Aleksandrovich Suchkov Nina Dzhansugovna Mzhavanadze Adelphina Felician Ncheye | 2018 | World Journal of Clinical Cases2018，6，6： | 2 |
| 6 | Piezore-sponse force microscopy:a window into electromechani-cal behavior at the nanoscale显示文摘 | Bonnell D A Kalinin S V Kholkin A L | 2009 | MRS Bull2009，34，9： | 1 |
| 7 | Water stability of aggregates in subtropical and tropical soils (Georgia and China) and its relationships with the minera- logy and chemical properties显示文摘 | Alekseeva TV Sokolowska Z Hajnos M Kalinin P1 | 2009 | Eurasian Soil Science2009，42，4： | 1 |
| 8 | Modeling of crystallization processes of cast iron grinding balls in casting molds of improved design 显示文摘 | SUSLO N V KALININ V T | 2011 | Metallurgical and Mining Industry2011，3，5： | 1 |
| 9 | ITER cryogenic system显示文摘 | Kalinin V Tada E Millet E | 2006 | Fusion Engineering and Design2006，81，： | 1 |
| 10 | Cytotoxic triterpene glycosides from far-eastern sea cucumbers belonging to the genus Cucumaria显示文摘 | OA Avilov SA Kalinin VI | 1997 | Liebigs Ann1997，12，： | 1 |
| 11 | Inorganic mercury expo- sure : toxicological effects, oxidative stress biomarkem and bioac- cumulation in the tropical freshwater fish matrinxa, Brycon ama- zonicus ( Spix and Agassiz, 1829 ) 显示文摘 | Monteiro D A Rantin F T Kalinin A L | 2010 | Ecotoxicology2010，19，1： | 1 |
| 12 | Topamax monotherapy of partial epilepsy显示文摘 | KALININ VV ZHELEZNOVA EV SOKOLOVA LV | 2004 | Zh Nevropatol Psikhiatr2004，104，7： | 1 |
| 13 | Assessment of the corrosion behavior ofstructural materials in the water coolant of ITER显示文摘 | BELOUS V KALININ G LORENZETTO P | 1998 | Journal of Nuclear1998，，： | 1 |
| 14 | On the Mechanism of Intergranular Corrosion of Aluminum Alloys显示文摘 | V. S. Sinyavskii V. V. Ulanova V. D. Kalinin | 2004 | Protection of Metals2004，，5： | 1 |
| 15 | Gender differences in risk factors of suicidal behavior in epilepsy显示文摘 | Kalinin W Polyanskiy DA | 2005 | Epilepsy Behav2005，6，3： | 1 |
| 16 | Local Impedance Irrmging and Spectroscopy of Polycrystalline ZnO Using Contact Atomic Force Microscopy 显示文摘 | SHAO R KALININ S V BONNELL D A | 2003 | Applied Physics Letters2003，82，： | 1 |
| 17 | Effect of alloying elements point of Fe-Ni invar alloys on the curie显示文摘 | Kalinin V M Dunaev F N Kornyakov V A | 1970 | Russian Physics Journal1970，13，5： | 1 |
| 18 | Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II显示文摘 | THOMA N H IAKOVENKO A KALININ H | 2001 | Biochemistry2001，40，： | 1 |
| 19 | Marine corrosion and protec tion of aluminum alloys according to their composition and structure显示文摘 | Sinyavskii V S Kalinin V D | 2005 | Protection of metals2005，41，4： | 1 |
| 20 | Local thermomechanieal characterization of phase transitions using band excitation atomic force acoustic microscopy with heated probe 显示文摘 | Jesse S Nikiforov M P Germinario L T Kalinin S V | 2008 | Applied Physics Letters2008，93，07： | 1 |
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