|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient显示文摘Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases. | Gilton Marques Fonseca André Luis Montagnini Manoel de Souza Rocha Rosely Antunes Patzina Mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 2 | Parenchymal-sparing liver surgery in patients with colorectal carcinoma liver metastases显示文摘Liver resection is the treatment of choice for patients with colorectal liver metastases(CLM).However,major resections are often required to achieve R0 resection,which are associated with substantial rates of morbidity and mortality.Maximizing the amount of residual liver gained increasing significance in modern liver surgery due to the high incidence of chemotherapyassociated parenchymal injury.This fact,along with the progressive expansion of resectability criteria,has led to the development of a surgical philosophy known as 'parenchymal-sparing liver surgery'(PSLS).This philosophy includes a variety of resection strategies,either performed alone or in combination with ablative therapies.A profound knowledge of liver anatomy and expert intraoperative ultrasound skills are required to perform PSLS appropriately and safely.There is a clear trend toward PSLS in hepatobiliary centers worldwide as current evidence indicates that tumor biology is the most important predictor of intrahepatic recurrence and survival,rather than the extent of a negative resection margin.Tumor removal avoiding the unnecessary sacrifice of functional parenchyma has been associated with less surgical stress,fewer postoperative complications,uncompromised cancer-related outcomes and higher feasibility of future resections.The increasing evidence supporting PSLS prompts its consideration as the gold-standard surgical approach for CLM. | Fernando A Alvarez Rodrigo Sanchez Claria Sebastian Oggero Eduardo de Santibanes | 2016 | World Journal of Gastrointestinal Surgery2016，8，6： | 8 |
| 3 | AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the reRulation of sperm motility显示文摘 | Violeta Calle-Guisado Ana Hurtado de Llera David Martin-Hidalgo Jose Mijares Maria C Gil Ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin | 2017 | Asian Journal of Andrology2017，19，6： | 5 |
| 4 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 5 | Intraoperative Management and Repair of Bile Duct Injuries Sustained during 10,123 Laparoscopic Cholecystectomies in a High-Volume Referral Center显示文摘 | Juan Pekolj Fernando A. Alvarez Martin Palavecino Rodrigo Sánchez Clariá Oscar Mazza Eduardo de Santiba?es | 2013 | Journal of the American College of Surgeons2013，，5： | 3 |
| 6 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 7 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 8 | Effect of climate and altitude on plant community composition and richness in Brazilian inselbergs显示文摘Plant communities are shaped by multiple factors along environmental gradients;however,studies are limited on how environmental filtering drives community composition and species richness on tropical inselbergs.We evaluate the influence of altitude and climatic variables related to temperature and precipitation on plant community composition and species richness on Brazilian inselbergs.We assume as a premise that both climate and altitude would induce changes on plant community composition and species richness at the local level.We used plant inventory data from 370 sampling units across four inselberg sites in the Atlantic Forest of Espírito Santo State,south-eastern Brazil.We tested the univariate and multivariate effects of altitude and climate variables on community composition and species richness with multiple models.Differences in species richness between inselbergs were evaluated using sample-based data to estimate rarefaction and extrapolation curves.In addition,differences in species composition and taxonomic beta diversity were examined via novel frequency-based metrics.A contrasting climate pattern was observed between the inselberg sites,with south sites being wet compared to the dry conditions found in northern sites.Species richness by rarefaction showed a similar pattern within regional sites;however,there were marked differences between regions.Species richness and beta diversity showed significant differences among sites,with higher values in southern sites than in northern sites.In a multi-model comparison between inselberg sites,altitude significantly influenced community composition and species richness and explained more variance than climate models.This finding suggested that climate could act to some extent on these tropical inselbergs;however,altitude was a better predictor of plant community composition and species richness at the local level. | Herval Vieira PINTO-JUNIOR Pedro Manuel VILLA Luis Fernando Tavares de MENEZES Miriam Cristina Alvarez PEREIRA | 2020 | Journal of Mountain Science2020，17，8： | 2 |
| 9 | High ALTlevel predict viremia in anti-HCV-positive HD patients if a modi-fied normal range of ALT is applied显示文摘 | Espinosa M Martin-Malo A Alvarez de Lara MA | 2000 | Clin Nephrol2000，54，2： | 1 |
| 10 | The ALPPS approach for the management of colorectal carcinoma liver metastases 显示文摘 | Alvarez FA Ardiles V de SantibafiesE | 2013 | Current C olorectal Cancer Reports2013，9，2： | 1 |
| 11 | On the Influence of Coupling AMC Resonances for RCS Reduction in the SHF Band显示文摘 | De Cos M E Alvarez Y Las-Heras F | 2011 | Progress in Eleetromagnetics Research2011，117，： | 1 |
| 12 | Modelling microclimate in urban environments and assessing its influence on the performance of surrounding buildings 显示文摘 | Francisco Samchez de la Flor Servando Alvarez Dominguez | 2004 | Energy and Buildings2004，，36： | 1 |
| 13 | Data and models for exploring sustainability of human well - being in global environmental change 显示文摘 | DEFFUANT G ALVAREZ I BARRETEAU O DE VRIES B EDMONDS B GILBERT | 2012 | European Physics Journal Special Topics2012，214，1： | 1 |
| 14 | Field and in vitro assay of three methods for freezing ram semen 显示文摘 | ANEL L De PAZ P ALVAREZ M | 2003 | Theriogenology2003，60，7： | 1 |
| 15 | Chronic obstructive puhnonary disease and heart failure 显示文摘 | Villar Alvarez F M6ndez Bail6n M de Miguel Diez J | 2009 | Arch Bronconeumol2009，45，8： | 1 |
| 16 | Micromophological characteristics of a marine ferromanganese crust 显示文摘 | Robustiano Alvarez Eric H De Carlo James Cowen | 1990 | Marine Geology1990，94，： | 1 |
| 17 | Effect of perorallyad ministered Lactobacillus macrophage activation in mice 显示文摘 | Perdigon G Nader de Macias M E Alvarez S | 1986 | Infect Immun1986，53，： | 1 |
| 18 | Relevance of dieta-ry lipids as modulators of immune functions mcells infected withListeria monocytogenes显示文摘 | Pueftollano MA de Pablo MA Alvarez de | 2002 | Clin Diagn Lab lmmuno12002，9，2： | 1 |
| 19 | Gene selection and classification of microarray data using random forest显示文摘 | Diaz-Uriarte R Alvarez de Andres S | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 20 | Rapid, nongenomic actions of retinoic aeid on phosphatidylinositol-3-kinase signaling pathway mediated by the rctinoic acid receptor显示文摘 | Masi? S Alvarez S de Lera AR | 2007 | Mol Endocrinol2007，21，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员