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| 1 | 大亚湾石珊瑚群落近25年的变化及其对2008年极端低温事件的响应显示文摘在气候变暖、ENSO加剧等导致全球珊瑚礁生态系统严重退化的背景下,相对高纬度海域的石珊瑚群落被认为是石珊瑚物种延续的最后保留地,但相对高纬度海域周期性的冬季低温是妨碍其发育的最重要因子之一.南海北部相对高纬度的大亚湾海区(22°31′~22°50′N)近40年来持续变暖,珊瑚群落发育但未成礁.2008年初经历了近50年来罕见的极端低温事件,持续32d,大亚湾海区2008年2月平均SST低于14℃,连续多天最低SST为12.3℃左右,低于传统认为的使珊瑚“致命”的温度(13℃),日最低气温则低达6.6℃.该海域的石珊瑚群落生态调查显示:(1)近25年来大亚湾石珊瑚覆盖度从76.6%下降到15.3%,退化达80%;(2)石珊瑚群落优势种由霜鹿角珊瑚变成秘密角蜂巢珊瑚;(3)2008年低温事件对本区石珊瑚群落没有造成明显影响,活珊瑚覆盖度没有发生明显变化.总体结果显示,相对高纬度的大亚湾海区的珊瑚种类已经总体上适应了极端低温的环境,具有进一步发育的潜力,可望在全球变暖背景下成为石珊瑚物种的避难所. | 陈天然 余克服 施祺 李淑 Gilbert J.Price 王嵘 赵美霞 陈特固 赵建新 | 2009 | 科学通报2009，54，6： | 25 |
| 2 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 3 | 多元线性回归模型的聚类分析方法研究显示文摘提出一种对大量的多元线性回归模型进行聚类分析的方法。首先利用增广矩阵的相关系数矩阵定义了2个多元回归模型之间的距离以及模型集合的质心和半径等相关概念。然后采用Squeezer聚类方法,以过程全自动化的方式,实现对多元线性回归模型集合进行聚类分析。通过仿真研究验证了方法的有效性,取得满意的分析结果。 | 王惠文 叶明 Gilbert Saporta | 2009 | 系统仿真学报2009，21，22： | 23 |
| 4 | Retinopathy of prematurity: an epidemic in the making显示文摘探索阻止并且对待早熟( ROP )的严重 retinopathy 的病原学,发生和方法的目的,它很快在早熟的婴儿的增加的数字是在这评论使用的数据主要从用英语出版的 Medline 和 PubMed 的 surviving.Data 来源的世界的区域正在成为威胁到婴儿的视觉。搜索词是“早熟和早熟的出生的 retinopathy ”我们讨论的 .Study 选择历史的观点,流行和发生,在为有严重 ROP 的眼睛的外部网膜的脱离能帮助的早熟的 babies.Results 的 ROP 的分类和处理方法阻止前进到盲目和几大临床的试用在高风险眼睛显示出这个处理的有效性。作为婴儿们熬过的 VLBW 和 ELBW 的一个更大的比例,在风险的婴儿的人口增加。在世界的各种各样的区域,不同鉴定标准作为需要被用来决定哪个婴儿在盲目的风险以便提供及时诊断考试和处理。为 preventiing ROP 的方法包括处于早熟,胎儿的 corticosteroids 的使用,和更好新生的照顾惯例的率导致减小的更好胎儿、产科的照顾。最近的开发显示了氧补充的管理为严重 ROP 的预防是重要的;然而,有还没知道浸透目标什么氧应该被采用。败血增加严重 ROP 在很 preterm 婴儿。基因协会和一条 telemedicine 途径可以被探索检测 ROP。 anti-VEGF 治疗的处理在有严重 ROP 的眼睛是潜在地有用的,但是长期的效果还没被知道,如此的处理应该与大 caution.Conclusions ROP 被使用是为与在最近的年里在许多国家改进新生的服务的发展正在变得更流行的早熟的婴儿的潜在地有约束力的疾病。高优先级应该被放在开发途径由减少 preterm 出生阻止 ROP 盲目上,改进以新生的照顾单位的早熟的婴儿的照顾,并且在那些区域提供足够的眼科的服务。 | Graham E. Quinn Clare Gilbert Brian A. Darlow Andrea Zin | 2010 | Chinese Medical Journal2010，，20： | 17 |
| 5 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 6 | Gram-Schmidt回归及在刀具磨损预报中的应用显示文摘多元线性回归是一种应用广泛的统计分析方法.在实际应用中,当自变量集合存在严重多重相关性时,普通最小二乘方法就会失效.为解决这一问题,利用Gram-Schmidt正交变换,提出一种新的多元线性回归建模方法——Gram-Schmidt回归.该方法可实现多元线性回归中的变量筛选,同时也解决了自变量多重相关条件下的有效建模问题.将该方法应用于机械加工过程中刀具磨损的预报分析,有效地进行了变量筛选,并得到了解释性强同时拟合优度也很高的模型结果. | 王惠文 陈梅玲 Gilbert Saporta | 2008 | 北京航空航天大学学报2008，34，6： | 14 |
| 7 | Epidemiology and natural history of hepatitis C virus infection显示文摘Hepatitis C virus(HCV)affects 130-210 million people worldwide and is one of the major risk factors for hepatocellular carcinoma.Globally,at least one third of hepatocellular carcinoma cases are attributed to HCV infection,and 350000 people died from HCV related diseases per year.There is a great geographical variation of HCV infection globally,with risk factors for the HCV infection differing in various countries.The progression of chronic hepatitis C to end-stage liver disease also varies in different study populations.A long-term follow-up cohort enrolling participants with asymptomatic HCV infection is essential for elucidating the natural history of HCV-caused hepatocellular carcinoma,and for exploring potential seromarkers that have high predictability for risk of hepatocellular carcinoma.However,prospective cohorts comprising individuals with HCV infection are still uncommon.The risk evaluation of viral load elevation and associated liver disease/cancer in HCV(REVEAL-HCV)study has followed a cohort of 1095 residents seropositive for antibodies against hepatitis C virus living in seven townships in Taiwan for more than fifteen years.Most of them have acquired HCV infection through iatrogenic transmission routes.As the participants in the REVEALHCV study rarely receive antiviral therapies,it provides a unique opportunity to study the natural history of chronic HCV infection.In this review,the prevalence,risk factors and natural history of HCV infection are comprehensively reviewed.The study cohort,data collection,and findings on liver disease progression of the REVEAL-HCV study are described. | Mei-Hsuan Lee Hwai-I Yang Yong Yuan Gilbert L’Italien Chien-Jen Chen | 2014 | World Journal of Gastroenterology2014，20，28： | 14 |
| 8 | Feedstock choice,pyrolysis temperature and type influence biochar characteristics:a comprehensive meta-data analysis review显示文摘Various studies have established that feedstock choice,pyrolysis temperature,and pyrolysis type influence final biochar physicochemical characteristics.However,overarching analyses of pre-biochar creation choices and correlations to biochar characteristics are severely lacking.Thus,the objective of this work was to help researchers,biochar-stakeholders,and practitioners make more well-informed choices in terms of how these three major parameters influence the final biochar product.Utilizing approximately 5400 peer-reviewed journal articles and over 50,800 individual data points,herein we elucidate the selections that influence final biochar physical and chemical properties,total nutrient content,and perhaps more importantly tools one can use to predict biochar’s nutrient availability.Based on the large dataset collected,it appears that pyrolysis type(fast or slow)plays a minor role in biochar physico-(inorganic)chemical characteristics;few differences were evident between production styles.Pyrolysis temperature,however,affects biochar’s longevity,with pyrolysis temperatures>500℃ generally leading to longer-term(i.e.,>1000 years)half-lives.Greater pyrolysis temperatures also led to biochars containing greater overall C and specific surface area(SSA),which could promote soil physico-chemical improvements.However,based on the collected data,it appears that feedstock selection has the largest influence on biochar properties.Specific surface area is greatest in wood-based biochars,which in combination with pyrolysis temperature could likely promote greater changes in soil physical characteristics over other feedstock-based biochars.Crop-and other grass-based biochars appear to have cation exchange capacities greater than other biochars,which in combination with pyrolysis temperature could potentially lead to longer-term changes in soil nutrient retention.The collected data also suggest that one can reasonably predict the availability of various biochar nutrients(e.g.,N,P,K,Ca,Mg,Fe,and Cu)based on feedstock choice and total nutrient content.Results can be used to create designer biochars to help solve environmental issues and supply a variety of plant-available nutrients for crop growth. | James A.Ippolito Liqiang Cui Claudia Kammann Nicole Wrage‑Mönnig Jose MEstavillo Teresa Fuertes‑Mendizabal Maria Luz Cayuela Gilbert Sigua Jeff Novak Kurt Spokas Nils Borchard | 2020 | Biochar2020，2，4： | 13 |
| 9 | 八角莲的愈伤组织和组培根及野生根状茎的鬼臼毒素含量比较研究显示文摘比较研究了峨眉山野生八角莲根、组培愈伤组织及其诱导根的鬼臼毒素含量,为八角莲的快速繁殖和利用生物技术生产鬼臼毒素提供科学依据.高效液相色谱技术(HPLC)显示组织培养的八角莲愈伤组织和诱导根中均含有鬼臼毒素,分别为0.117%和0.148%,野生品的根中其含量为0.600%.通过组织培养可在不破坏自然资源的前提下快速生产鬼臼毒素,从而为开发鬼臼毒素类抗癌药物提供大量原料. | 潘琦 陈绍瑗 姜维梅 Gilbert Y S Chan 傅承新 | 2006 | 浙江大学学报(农业与生命科学版)2006，32，1： | 13 |
| 10 | Age distribution,polyps and rectal cancer in the Egyptian population-based cancer registry显示文摘AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies.METHODS:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998.We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007.All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted:age,residence,diagnosis date,grade,stage,topology,clinical characteristics,and histology variables.Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age,sex,residence and other related demographic factors.In addition to age-and sex-specific incidence rate analyses,we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province.We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results(SEER) data of the United States.RESULTS:Over the 9 year-period,1364 colorectal cancer cases were included.The disease incidence under age 40 years was relatively high(1.3/10 5) while the incidence in the age groups 40 and over was very low(12.0/10 5,19.4/10 5 and 21.2/10 5 in the age groups 40-59 years,60-69 years and > 70 years,respectively).The vast majority of tumors(97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum.Colorectal cancer was more common in patients from urban(55%) than rural(45%) areas.Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population.The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years.The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER.CONCLUSION:Low rate of polyps,low incidence in older subjects,and high rate of rectal cancer in Egypt.Future studies should explore clinical and molecular disease patterns. | Darlene Veruttipong Amr S Soliman Samuel F Gilbert Taylor S Blachley Ahmed Hablas Mohamed Ramadan Laura S Rozek Ibrahim A Seifeldin | 2012 | World Journal of Gastroenterology2012，18，30： | 12 |
| 11 | A “GC-rich” method for mammalian gene expression:A dominant role of non-coding DNA GC content in the regulation of mammalian gene expression显示文摘High mammalian gene expression was obtained for more than twenty different proteins in different cell types by just a few laboratory scale stable gene transfections for each protein.The stable expression vectors were constructed by inserting a naturally-occurring 1.006 kb or a synthetic 0.733 kb DNA fragment(including intron) of extremely GC-rich at the 5’ or/and 3’ flanking regions of these protein genes or their gene promoters.This experiment is the first experimental evidence showing that a non-coding extremely GC-rich DNA fragment is a super 'chromatin opening element' and plays an important role in mammalian gene expression.This experiment has further indicated that chromatin-based regulation of mammalian gene expression is at least partially embedded in DNA primary structure,namely DNA GC-content. | Gilbert Rishton Matthew (Mizhou) HUI | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 12 | 1988-2008全球盲的改变显示文摘一、视力损害的患病率
1.人口的改变当
1988年社区健康杂志开始发行时,世界人口是约51亿,20年后,这一数字已经增加了约30%,达到67亿;同时,世界人口的老龄化也非常明显,20年间65岁以上的老人增长了55%,从3.2亿增加到5亿,而已有的证据表明视力损害的患病率在老年人中要高的多。 | Allen Foster Clare Gilbert Gordon Johnson 顾永昊 | 2009 | 实用防盲技术2009，4，1： | 10 |
| 13 | Impact of brine acidification on hatchability, survival and reproduction of Artemia parthenogenetica and Artemia franciscana in salt ponds, Bohai Bay, China显示文摘We studied the effect of pH(pH 5, 6, 7 and 8) on the hatching percentage, survival and reproduction of Artemia strains in Bohai Bay salt ponds. Strains included parthenogenetic Artemia from Bohai Bay(BHB), Artemia franciscana from San Francisco Bay, and A. franciscana artifi cially produced in salt ponds in Vietnam. The latter was included as a potential inoculum for biological management of salt ponds. The hatching percentage of cysts after 24 h and the survival rate of the tested Artemia strains were signifi cantly reduced when exposed to a culture medium at pH 5 for 18 d( P <0.05). The tolerance of Artemia to 48 h acid exposure varied with developmental stage, increasing in the following order: juvenile, nauplii, pre-adult, with maximum tolerance in adults. All strains of Artemia tested could not reproduce at pH 5. At pH levels from pH 6–8, a higher pH generally resulted in a shorter brood interval and enhanced ovoviviparity. Hence, we suggest that brine acidifi cation has a negative impact on Artemia populations in the Bohai Bay saltworks. Inoculation of Artemia with either local parthenogenetic Artemia or exotic A. franciscana should be feasible at pH 7–8. | 隋丽英 邓元告 王婧 SORGELOOS Patrick VAN STAPPEN Gilbert | 2014 | Chinese Journal of Oceanology and Limnology2014，32，1： | 10 |
| 14 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 15 | Yb掺杂原子数分数为0.5%的Yb∶Y_3Al_5O_(12)晶体的光谱分析显示文摘采用提拉法生长了Yb掺杂原子数分数为0.5%的Yb∶Y3Al5O12(Yb∶YAG)晶体,对晶体的吸收光谱和荧光光谱进行了分析。与Yb掺杂原子数分数为5%的Yb∶YAG晶体进行了对比,得出采用940 nm激光二极管(LD)抽运晶体最为合适。原子数分数为0.5%的Yb∶YAG晶体相对于原子数分数为5%的Yb∶YAG晶体自吸收效应的影响要小。测量了原子数分数为0.5%的Yb∶YAG晶体的荧光寿命为0.95 ms,与理论值很接近。因此采用原子数分数为0.5%的Yb∶YAG晶体作为激光工作物质将有利于高效、小型集成化的固体激光器的发展。 | 王晓丹 赵志伟 徐晓东 宋平新 姜本学 徐军 邓佩珍 Gilbert Bourdet J.-C.Chanteloup | 2006 | 中国激光2006，33，5： | 9 |
| 16 | Biochar compost blends facilitate switchgrass growth in mine soils by reducing Cd and Zn bioavailability显示文摘Biochars have the potential to reclaim mine-impacted soils;however,their variable physico-chemical properties incite specu-lation about their successful remediation performance.This investigation examined the capability of biochars produced from three different feedstocks along with a compost blend to improve switchgrass growth conditions in a mine-impacted soil by examining influences on soil pH,grass metal contents,and soil-extractable metal concentrations.Cadmium(Cd)-and zinc(Zn)-contaminated mine soil was collected from a site near Webb City,Missouri,USA-a location within the Tri-State Min-ing District.In a full factorial design,soil was treated with a 0%,2.5%,and 5%(w/w)compost mixture(wood chips+beef cattle manure),and 0%,2.5%and 5%of each biochar pyrolyzed from beef cattle manure,poultry litter,and lodgepole pine feedstocks.Switchgrass(Panicum virgatum,‘Cave-In-Rock’variety)was grown in a greenhouse for 50 days and the mass of shoots(above-ground biomass)and roots was assessed,while soil pH,deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations were measured.Poultry litter biochar and compost had the greatest ability to raise soil pH(from 4.40 to 6.61),beef cattle manure biochar and compost moderately raised pH(from 4.4 to 5.92),and lodgepole pine biochar and compost weakly raised pH(from 4.40 to 5.05).Soils treated with beef cattle manure biochar,poultry litter biochar signifi-cantly reduced deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations,while lodgepole pine biochar-treated soils showed mixed results.Switchgrass shoot and root masses were greatest in soil treated with compost in combination with either beef cattle manure biochar or poultry litter biochar.Soils treated with 5%beef cattle manure biochar+5%compost had greater reductions in total Cd and Zn concentrations measured in switchgrass shoots and roots compared to the other two treatments.The three biochars and compost mixtures applied to heavy metal,mine-impacted soil had considerable performance dissimilarities for improving switchgrass productivity.Switchgrass growth was noticeably improved after treatment with the compost in combination with biochar from beef cattle manure or poultry litter.This may be explained by the increased soil pH that promoted Zn and Cd precipitation and organic functional groups that reduced soil-available heavy metal concentrations.Our results imply that creating designer biochars is an important management component in developing successful mine-site phytostabilization programs. | Jeffrey M.Novak James A.Ippolito Donald W.Watts Gilbert C.Sigua Thomas F.Ducey Mark G.Johnson | 2019 | Biochar2019，1，1： | 8 |
| 17 | AN ECO- AND INNO-PRODUCT DESIGN SYSTEM APPLYING INTEGRATED AND INTELLIGENT QFDE AND TRIZ METHODOLOGY显示文摘The green environmental laws and regulations are legislated, implemented, and enforced in many countries and economic regions. The provision of green products and services are the fast growing trend in global consumer markets. Therefore, introducing new products with environmental considerations becomes critical for global brand manufacturers. This research depicts an integrated and intelligent eco- and inno-product design methodology to support environmental friendly green product development. The methodology adopts approaches, such as life cycle assessment (LCA), quality function deploymnet for environement (QFDE), theory of inventive problem solving (TRIZ) and back-propagation network (BPN) to achieve eco- and inno-design objectives. LCA evaluates and compares the environmental impacts of production. QFDE transforms high-level concerns of environment into design requirements. When there are many historical QFDE data, the BPN prediction model is trained and deployed to automate the specifications of green design improvement. TRIZ is to support the creation of innovative product design ideas effectively and efficiently during the concept design stage. Finally, this paper presents two eco-design cases of power adaptor to demonstrate the proposed methodology. | Amy J.C. TRAPPEY Jerry J.R. OU Gilbert Y.P. LIN Meng-Yu CHEN | 2011 | Journal of Systems Science and Systems Engineering2011，20，4： | 7 |
| 18 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 19 | 聚合酶链反应与反向线点杂交检测沙眼衣原体及分型显示文摘目的建立和评价一个新的多重和巢式PCR反向线点杂交试验(RLB)检测泌尿生殖道沙眼衣原体及其分型方法。方法该试验设计了3对引物分别针对CT外膜蛋白(omp1)基因VD2区和质粒进行扩增,用CT15种血清型(A、B/Ba、C、D/Da、E、F、G/Ga、H、I/Ia、J、Ja、K、L1、L2和L3)探针与扩增后的产物杂交。经COBASAmplicor检测的355份标本,其中277份尿液,2份男性直肠拭子和78份女性宫颈试子,进行PCRRLB检测CT并分型。结果192份COBASAmplicor阳性标本中175份PCRRLB阳性,其中93.1%(163/175)的CT感染可被正确分型,其单一型感染分型结果与DNA测序结果一致。163份COBASAmplicor阴性标本中6份巢式PCRRLB阳性。85.3%(139/163)为单一型CT感染,最常见的CT是E(38.6%)F(28.5%)和D(18.2%)。14.7%(24/163)为CT混合感染,混合感染以H和K为主。结论PCRRLB检测CT是一种简便、快速、特异和敏感的方法,并准确的进行CT分型,为CT感染的临床诊断和分子流行病学研究提供了一种可靠的方法。 | 熊礼宽 孔繁荣 周华 程锦泉 Lyn Gilbert | 2006 | 中华检验医学杂志2006，29，3： | 6 |
| 20 | Porous media grain size distribution and hydrodynamic forces effects on transport and deposition of suspended particles显示文摘The effects of porous media grain size distribution on the transport and deposition of polydisperse suspended particles under different flow velocities were investigated. Selected Kaolinite particles(2–30 μm) and Fluorescein(dissolved tracer) were injected in the porous media by step input injection technique. Three sands filled columns were used: Fine sand,Coarse sand, and a third sand(Mixture) obtained by mixing the two last sands in equal weight proportion. The porous media performance on the particle removal was evaluated by analysing particles breakthrough curves, hydro-dispersive parameters determined using the analytical solution of convection–dispersion equation with a first order deposition kinetics, particles deposition profiles, and particle-size distribution of the recovered and the deposited particles. The deposition kinetics and the longitudinal hydrodynamic dispersion coefficients are controlled by the porous media grain size distribution. Mixture sand is more dispersive than Fine and Coarse sands. More the uniformity coefficient of the porous medium is large, higher is the filtration efficiency. At low velocities, porous media capture all sizes of suspended particles injected with larger ones mainly captured at the entrance.A high flow velocity carries the particles deeper into the porous media, producing more gradual changes in the deposition profile. The median diameter of the deposited particles at different depth increases with flow velocity. The large grain size distribution leads to build narrow pores enhancing the deposition of the particles by straining. | Nasre-Dine Ahfir Ahmed Hammadi Abdellah Alem HuaQing Wang Gilbert Le Bras Tariq Ouahbi | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
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