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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | Malignant Progression in IPMN: A Cohort Analysis of Patients Initially Selected for Resection or Observation显示文摘 | J. LaFemina N. Katabi D. Klimstra C. Correa-Gallego S. Gaujoux T. P. Kingham R. P. DeMatteo Y. Fong M. I. D’Angelica W. R. Jarnagin R. K. Do M. F. Brennan Peter J. Allen | 2013 | Annals of Surgical Oncology2013，，2： | 2 |
| 4 | Operative Drainage Following Pancreatic Resection: Analysis of 1122 Patients Resected Over 5 Years at a Single Institution显示文摘 | Camilo Correa-Gallego Murray F. Brennan Michael D?Angelica Yuman Fong Ronald P. DeMatteo T. Peter Kingham William R. Jarnagin Peter J. Allen | 2013 | Annals of Surgery2013，，6： | 2 |
| 5 | Nano-engineering block copolymer aggregates for drug delivery 显示文摘 | Allen C Eisenberg A Maysinger D | 1999 | Colloids Surf B Biointerfaces1999，16，1： | 2 |
| 6 | Laparoscopic Distal Pancreatectomy: Evolution of a Technique at a Single Institution显示文摘 | Shiva Jayaraman Mithat Gonen Murray F. Brennan Michael I. D’Angelica Ronald P. DeMatteo Yuman Fong William R. Jarnagin Peter J. Allen | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 7 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 8 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 9 | The relationship between career motivation and self-efficacy with protégé career success显示文摘 | Rachel Day Tammy D Allen | 2003 | Journal of Vocational Behavior2003，，1： | 2 |
| 10 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 11 | The expert consensus guideline series : Treatment of behavioral emergencies 2005 显示文摘 | Allen MH Currier GW Carpenter D | 2005 | J Psychiatr Pract2005，11，1： | 1 |
| 12 | Image method for efficiently simulating small room acoustics显示文摘 | ALLEN J BERKLEY D | 1979 | Journal of the Acoustic Society of America1979，，： | 1 |
| 13 | Spatial and temporal variation of nitrous oxide and methane flux between subtropical mangrove sediments and the atmosphere显示文摘 | ALLEN D E DALAL R C RENNENBERG H | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 14 | Fine particulate matter source attribution for Southeast Texas using ^14C/^13C ratios 显示文摘 | Lemire K R Allen D T Klouda G A | 2002 | J Geophys Res2002，107，22： | 1 |
| 15 | Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress显示文摘 | WANG J ZHANG H ALLEN R D | 1999 | Plant Cell Physiology1999，40，7： | 1 |
| 16 | A Formal Basis for Architectural Connection显示文摘 | Allen R Garlan D | 1997 | ACM Transactions on Software Engineering and Methodo-logy1997，6，3： | 1 |
| 17 | Nonlinear shear instabilities of alongshore currents over barred beaches 显示文摘 | Slinn D N Allen J S Newberger P A | 1998 | Journal of Geophysical Research1998，103，18： | 1 |
| 18 | Wide band imped- ance matching: H∞ performance bounds显示文摘 | SCHWARTZ D F ALLEN J C | 2004 | IEEE Transactions on Circuit and Systems--II: Express Briefs2004，51，7： | 1 |
| 19 | Bubbles, Crises and policy显示文摘 | Allen F Gale D | 1998 | Oxford Review of Economic Policy1998，15，3： | 1 |
| 20 | Further studies of the fire resistance of reinforced concrete columns显示文摘 | Allen D E Lie T T | 1974 | National research Council of Canada1974，416，： | 1 |
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