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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Auditor brand name reputations and industry specializations显示文摘 | Allen T Craswell Jere R Francis Stephen L Taylor | 1995 | Journal of Accounting and Economics1995，，3： | 4 |
| 3 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 4 | A comparison of liquid hot water and steam pretreatments of sugar cane bagasse for bioconversion to ethanol显示文摘 | Mark Laser Deborah Schulman Stephen G Allen Joseph Lichwa Michael J Antal Lee R Lynd | 2001 | Bioresource Technology2001，，1： | 2 |
| 5 | Initiating insulin therapy in type 2 diabetes:a comparison of biphasic and basal insulin analogs显示文摘 | Raskin R Allen E Hollander P | | Diabetes Care0，，： | 2 |
| 6 | Oxidative stress and superoxide dismutase in development,aging and gene regulation显示文摘 | Allen R G | 1998 | Age1998，21，： | 2 |
| 7 | An update for the calculation of reference evapotranspiration显示文摘 | ALLEN R G SMITH M | 1994 | ICID Bulletin1994，43，2： | 2 |
| 8 | Design and Analysis of a Compact,Wide Field, Unobscured, Zoom Mirror System显示文摘 | R Barry Johnson Mann Allen | 1997 | Proceedings of SPIE1997，3129，： | 2 |
| 9 | Spatial and temporal variation of nitrous oxide and methane flux between subtropical mangrove sediments and the atmosphere显示文摘 | ALLEN D E DALAL R C RENNENBERG H | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 10 | The influence of fetal genotype upon endometrial cup development and PMSG and progestagen production in equids显示文摘 | Allen W R | 1975 | J Reprod Fertil1975，，： | 1 |
| 11 | Fine particulate matter source attribution for Southeast Texas using ^14C/^13C ratios 显示文摘 | Lemire K R Allen D T Klouda G A | 2002 | J Geophys Res2002，107，22： | 1 |
| 12 | Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress显示文摘 | WANG J ZHANG H ALLEN R D | 1999 | Plant Cell Physiology1999，40，7： | 1 |
| 13 | A Formal Basis for Architectural Connection显示文摘 | Allen R Garlan D | 1997 | ACM Transactions on Software Engineering and Methodo-logy1997，6，3： | 1 |
| 14 | Porter's generic strategies:An exploratory study of their use in JAPAN显示文摘 | Allen R S Helms M M Takeda M B | 2007 | Journal of Business Strategies2007，24，1： | 1 |
| 15 | Final surface error correction of an off-axis aspheric petal by ion figuring显示文摘 | ALLEN L N HANNON J J WAMBACH R W | 1992 | SPIE1992，1543，： | 1 |
| 16 | Risky business:The role of risk in voluntary turnover decisions显示文摘 | David G Allen Robert W R Karen R MJarnes M V | 2007 | Human Resource Management Review2007，17，： | 1 |
| 17 | A mechanistic classification of thora- columbar spine fractures 显示文摘 | Ferguson RL Allen BL J r | 1984 | Clin Orthop Relat Res1984，，189： | 1 |
| 18 | Red imported fire ant impacts on northern bobwhite populations显示文摘 | Allen C R Lutz R S Demarais S | 1995 | Ecol Appl1995，，3： | 1 |
| 19 | Prediagnostic symptom recognition and help seeking among cancer patients 显示文摘 | Mor V Masterson - Allen S Goldberg R | 1990 | J Community Health1990，15，4： | 1 |
| 20 | The impact of FLT3 intenaal tandem duplication mutant level, number, size,and interaction with NPM1 mutations in a large co- hort of young adult patients with acute myeloid leukemia 显示文摘 | GALE R E GREEN C ALLEN C | 2008 | Blood2008，111，： | 1 |
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