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| 1 | Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions显示文摘·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with radiotherapy.Thirty-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions. | Lukas Reznicek Carmen Stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer Marcus Kernt | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 2 | Navigated laser in diabetic macular edema: the impact of reduced injection burden on patients and physicians-who wins and who loses?显示文摘We inquired the impact of reduced therapy discontinuation in diabetic macular edema(DME) on physician's revenue considering anti-vascular endothelial growth factor(VEGF) monotherapy and its combination with Navilas treatment. Data were collected on injection frequency, treatment discontinuation and reimbursement fees for DME treatment with anti-VEGF compared to anti-VEGF in combination with navigated laser. Based on these data an economic model was built to compare physicians revenue over a 5y period using either therapy for 4 European countries and the USA. Due to patients' higher therapy adherence, physicians using navigated laser therapy with anti-VEGF generate similar or higher revenues compared to VEGF monotherapy in all analyzed countries. The use of Navilas decreases the patient's injection burden at the same clinical outcome, while the physician's revenue remained stable or increased. Therewith, therapy discontinuation in DME can be reduced using the combination therapy with Navilas. | Jacob Menzler Aljoscha Neubauer Focke Ziemssen | 2019 | International Journal of Ophthalmology(English edition)2019，12，2： | 3 |
| 3 | Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy显示文摘AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic retinopathy.METHODS: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was included.Leak-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic location.Leaking was defined by late phase fluorescein angiograms compared to early phase.Retinal thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm circle.RESULTS: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,respectively.CONCLUSION: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution OCT.Therefore,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening. | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 4 | Comparison of Intravitreal Bevacizumab versus Triamcinolone for the Treatment of Diffuse Diabetic Macular Edema显示文摘 | Kreutzer Thomas C Al Saeidi Rashid Kook Daniel Wolf Armin Ulbig Michael W Neubauer Aljoscha S Haritoglou Christos | 2010 | Ophthalmologica2010，，4： | 2 |
| 5 | 糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)显示文摘目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25~51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。 | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | 国际眼科杂志2011，11，7： | 1 |
| 6 | Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC显示文摘Poly(lactide-co-glycolide acid)(PLGA) is an extraordinary well-described polymer and has excellent pharmaceutical properties like high biocompatibility and good biodegradability. Hence, it is one of the most used materials for drug delivery and biomedical systems, also being present in several US Food and Drug Administration-approved carrier systems and therapeutic devices. For both applications, the quantification of the polymer is inalienable. During the development of a production process, parameters like yield or loading efficacy are essential to be determined. Although PLGA is a well-defined biomaterial,it still lacks a sensitive and convenient quantification approach for PLGA-based systems. Thus, we present a novel method for the fast and precise quantification of PLGA by RP-HPLC. The polymer is hydrolyzed into its monomers, glycolic acid and lactic acid. Afterwards, the monomers are derivatized with the absorption-enhancing molecule 2,4′-dibromoacetophenone. Furthermore, the wavelength of the derivatized monomers is shifted to higher wavelengths, where the used solvents show a lower absorption,increasing the sensitivity and detectability. The developed method has a detection limit of 0.1 mg/mL,enabling the quantification of low amounts of PLGA. By quantifying both monomers separately, information about the PLGA monomer ratio can be also directly obtained, being relevant for degradation behavior. Compared to existing approaches, like gravimetric or nuclear magnetic resonance measurements, which are tedious or expensive, the developed method is fast, ideal for routine screening, and it is selective since no stabilizer or excipient is interfering. Due to the high sensitivity and rapidity of the method, it is suitable for both laboratory and industrial uses. | Marcel Pourasghar Aljoscha Koenneke Peter Meiers Marc Schneider | 2019 | Journal of Pharmaceutical Analysis2019，9，2： | 1 |
| 7 | Tissue-specific expression patterns of the RAGE receptor and its soluble forms—a result of regulated alternative splicing?显示文摘 | Claudia Schlueter Sven Hauke Aljoscha M. Flohr Piere Rogalla J?rn Bullerdiek | 2003 | BBA - Gene Structure and Expression2003，，1： | 1 |
| 8 | 3DAV exploration of video-based rendering technology in MPEG显示文摘 | Aljoscha S Chen M C | 2004 | IEEE Transactions on Circuit and Systems for Video Technology2004，14，3： | 1 |
| 9 | Tissue-specific expression patterns of the RAGE receptor and its soluble forms-a result of regulated alternative splicing显示文摘 | Schlueter C Hauke S Aljoscha M | 2003 | Biochim Biophys Acta2003，1630，： | 1 |
| 10 | Measuring emotional management abilities: Further evidence of the importance to distinguish between typical and maximum performance 显示文摘 | H HARALD FREUDENTHALER ALJOSCHA G NEUBAUER | 2007 | Personality and Individual Differences2007，42，： | 1 |
| 11 | 玻璃体腔注射贝伐单抗治疗PDR黄斑水肿后患者的满意度和视力(英文)显示文摘目的:增生性糖尿病性视网膜病播散性视网膜激光光凝后,用非选择性抗VEGF抑制剂贝伐单抗治疗糖尿病性黄斑水肿,调查患者自我评估的视功能及视力。方法:30例30眼增生性糖尿病性视网膜病伴持续性糖尿病性黄斑水肿连续病例,播散性视网膜激光光凝后,1.25mg贝伐单抗0.05mL (Avastin)单剂量玻璃体腔注射治疗。对照组包括30例30眼增生性糖尿病性视网膜病,只接受播散性视网膜激光光凝。主要的调查结果包括Snellen视力,眼底临床检查和患者自我用0-100分数值范围评价的视觉质量。结果:贝伐单抗组的平均基线视力为0.48±0.58 logMAR,对照组为0.61±0.78 (两组无显著差异)。6mo后,视力没有显著的变化,贝伐单抗组和对照组分别为0.33±0.41和0.52±0.68。临床检查显示黄斑水肿仅有一些改善趋势。患者用直观模拟标度尺主观评价视功能结果显示注射贝伐单抗6mo后由60.2±17.5改善至76.0±15.6 (P<0.001)。对照组自我评估视功能平均值为59.6±19.8,与贝伐单抗组基线值无显著差异,但是低于注射贝伐单抗后分数,差异有高度显著性(P<0.01)。结论:治疗增生性糖尿病性视网膜病的黄斑水肿,贝伐单抗(Avastin)玻璃体腔注射作为播散性激光光凝的辅助治疗较单纯的激光治疗后患者满意度和自我评价的视力显著改善。患者视力在6mo后无明显变化。 | Lala Ceklic Slobodanka Latinovic Aljoscha S Neubauer Marijana Malesevic | 2009 | 国际眼科杂志2009，9，9： | 1 |
| 12 | Evaluation of a novel Scheimpflug-based non-contact tonometer in healthy subjects and patients with ocular hypertension and glaucoma显示文摘 | Lukas Reznicek Daniel Muth Anselm Kampik Aljoscha S Neubauer Christoph Hirneiss | 2013 | British Journal of Ophthalmology2013，，11： | 1 |
| 13 | Evaluation of minimally invasive therapies and rationale for a prospective randomized trial to evaluate selective intra-arterial lysis for clinically complete central retinal artery occlusion显示文摘 | Arthur J Aljoscha S Ulrich S | 2003 | Archives of Ophthalmology2003，24，9： | 1 |
| 14 | Semi - supervised learning in knowledge discovery显示文摘 | Aljoscha Klose Rudolf Kruse | 2005 | Fuzzy Sets and Systems2005，，149： | 1 |
| 15 | 新颖的立体内容制作工具显示文摘目前,立体影视正逐步成为大众消费产品。然而,尽管立体节目数量正在迅速增加、相关技术也在不断进步,但是立体节目制作和显示仍然存在诸多难题,例如控制和调整实景拍摄内容的立体感就是其中一个重要问题,因为有效改变深度相当于调整摄像机的基线距离和会聚角。在已有的后期制作工具中,基线距离和会聚角的调整涉及复杂且昂贵的图像分割、密集深度重建以及图像修复。本文概括了现有立体内容编辑技术及目前难题,并阐述了关于视差校正、深度信息编辑、显示调整以及2D/3D格式转换等最新研究成果及解决方案。 | Alexander Hornung Aljoscha Smolic Markus Gross 刘茂英(译) 方捷新(译) 刘达(校) | 2010 | 现代电影技术2010，，12： | 1 |
| 16 | Evaluation of Minimally lnvasive therapies and rationale for a prospective randomized trial to evaluate selecfive intra-arterial lysis for clinically complete central Retinal artery Occlusion显示文摘 | Arthur J Aljoscha S Ulrich S | 2003 | Arch Ophthalmol2003，121，： | 1 |
| 17 | Endovascular Treatment of Common Femoral Artery Disease显示文摘 | Robert F. Bonvini Aljoscha Rastan Sebastian Sixt Elias Noory Thomas Schwarz Ulrich Frank Marco Roffi Pierre André Dorsaz Uwe Schwarzw?lder Karlheinz Bürgelin Roland Macharzina Thomas Zeller | 2011 | Journal of the American College of Cardiology2011，，8： | 1 |
| 18 | Central Retinal Artery Occlusion: Local Intra-arterial Fibrinolysis versus Conservative Treatment, a Multicenter Randomized Trial显示文摘 | Martin Schumacher Dieter Schmidt Bernhard Jurklies Christine Gall Isabel Wanke Claudia Schmoor Herbert Maier-Lenz Laszlo Solymosi Hartmut Brueckmann Aljoscha S. Neubauer Armin Wolf Nicolas Feltgen | 2010 | Ophthalmology2010，，7： | 1 |
| 19 | Initial experience with the 5 x300 mm proteus embolic capture angioplasty balloon in the treatment ofperipheral vascular disease显示文摘 | Thomas Z Andrej S Aljoscha R | 2012 | J Endovasc Ther2012，19，6： | 1 |
| 20 | Comparison of prednisolone 1%, rimexolone 1% and ketorolac tromethamine 0.5% after cataract extraction显示文摘 | Christoph Hirnei? Aljoscha S. Neubauer Anselm Kampik Carl-Ludwig Sch?nfeld | 2005 | Graefe’s Archive for Clinical and Experimental Ophthalmology2005，，8： | 1 |
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