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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘 | Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | Randomized trials of radiotherapy alone versus comined chemotherapy and radiotherapy in stage Ⅲ a and Ⅲ b nonsmall cell lung cancer:a meta-analysis显示文摘 | Armando P Alessandra C | 1995 | Cancer1995，76，4： | 1 |
| 5 | In congenital hypothyroidism bone maturation at birth may be a predictive factor of psychomotor development during the first year of life irrespective of other variables related to treatment显示文摘 | Malgorzata W Filippo DL Alessandra C | 2003 | Eur J Endocrinol2003，149，1： | 1 |
| 6 | Synthesis and antitubercular activity of novel amino acid derivatives 显示文摘 | Cristiane F Da C Alessandra C | 2012 | Chem Biol Drug Des2012，79，22： | 1 |
| 7 | Enantioselective 1,3-dipolar cycloadditions of unsaturated aldehydes promoted by apoly( ethylene glycol)-supported organic catalyst显示文摘 | Alessandra P M aurizio B M auro C e t a l | 2004 | E ur J Org Chem2004，344，： | 1 |
| 8 | Effect of additives in the casting solution on the formation of PVDF membranes显示文摘 | Fontananova Enrica Jansen Johannes C Cristiano Alessandra | 2006 | Desalination2006，192，13： | 1 |
| 9 | Changes of flavonoids,vitamin Cand antioxidant capacity in minimally processed citrus segments and juices during storage显示文摘 | ALESSANDRA D C ANTONIO P VINCENZO V | 2004 | Food Chemistry2004，84，： | 1 |
| 10 | Present and future of recombinant gonadotropins in reproductive medicine 显示文摘 | Vincenzo D L Maria M C Alessandra D S | 2012 | Curr Pharmac Biotech2012，13，3： | 1 |
| 11 | Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells显示文摘 | Alessandra C Sara P Fabrizio D A | 2009 | J Pineal Res2009，46，3： | 1 |
| 12 | Poly(hydroxylbutyrate-co-hydroxyvalerate) bilayer skin tissue engineering constructs with improved epidermal rearrange-ment显示文摘 | Alessandra Z Mariana C T Silviene N | 2014 | Macromolecular Bioscience2014，14，7： | 1 |
| 13 | Financial constraints to inno- vation in the UK: Evidence from CIS2 and CIS3显示文摘 | Alessandra C Stoneman P | 2008 | Oxf- ord Economic Papers2008，60，4： | 1 |
| 14 | Fingerprint classification by directional image partitioning显示文摘 | Raffaele C Alessandra L Dario M | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，5： | 1 |
| 15 | 显示文摘 | Eliangela M T Alessandra L D R Antonio J F C | 2005 | Macromol Symp2005，229，： | 1 |
| 16 | Effect of biodegradable chelating agents on heavy metals phytoextraction with Mirabilis jalapa and on its associated bacteria显示文摘 | Alessia C Alessandra C Tiziana L | 2007 | European journal of soil biology2007，43，： | 1 |
| 17 | Columbia University's Axel Patents: Technology Transfer and Implications for the Bayh-Dole Act显示文摘 | Alessandra C Robert C D | 2009 | Milbank Quarterly2009，87，3： | 1 |
| 18 | Synthesis of analogues of calicheamicin and neocarzinostatin chromophore显示文摘 | Alessandra C Angela R M John M | 2004 | Tetrahedron2004，60，： | 1 |
| 19 | Animal-assisted interventions as innovative tools for mental health显示文摘 | Francesca C Marta B Alessandra B | 2011 | Ann Ist Super Sa- nita2011，47，34： | 1 |
| 20 | The influence of erbium: yttrium-aluminum-garnet laser ablation with variable pulse width on morphology and microleakage of composite restorations显示文摘 | Ricardo SN Sheila GS Alessandra C et M | 2010 | Lasers Med Sci2010，25，： | 1 |
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