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| 1 | Different patterns of intestinal response to injury after arterial,venous or arteriovenous occlusion in rats显示文摘AIM:To investigate the differences in injury patterns caused by arterial, venous or arteriovenous mesenteric occlusion.METHODS: Male Wistar rats were separated equally into four groups. Occlusion was performed by clamping the superior mesenteric artery (A), the mesenteric vein (V) or both (AV) for 30 min, followed by 60 min of reperfusion. A control group received sham surgery only. Intestinal sections were examined for histological damage and serum tumor necrosis factor-α (TNF-α), endothelin-1 (ET-1), P-selectin, antithrombin (AT) and soluble intracellular adhesion molecule-1(ICAM-1) concentrations were measured. RESULTS: All groups showed signif icant mucosal injury compared to controls. Furthermore, mucosal injury was significantly more severe in the V and AV groupscompared to the A group (3.6±0.55, 3.4±0.55 and 2±0.71, respectively, P=0.01). ICAM-1 was similarly elevated in all groups, with no significant differences between the groups. P-selectin levels were significantly elevated in the V and AV groups but not the A group (1.4±0.5 ng/mL, 2.52±0.9 ng/mL and 0.02±0.01 ng/mL, respectively, P=0.01) and ET-1 was significantly elevated in the A and V groups but not the AV group (0.32±0.04 pg/mL, 0.36±0.05 pg/mL and 0.29±0.03 pg/mL, respectively, P=0.01) compared to sham controls. AT CONCLUSION:Different patterns of response to ischemia/reperfusion are associated with venous, arterial or arteriovenous occlusion. Venous and arteriovenous occlusion was associated with the most severe alterations. | Francisco Javier Guzmán-de la Garza Carlos Rodrigo Cámara-Lemarroy Gabriela Alarcón-Galván Paula Cordero-Pérez Linda Elsa Muoz-Espinosa Nancy Esthela Fernández-Garza | 2009 | World Journal of Gastroenterology2009，15，31： | 10 |
| 2 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 3 | One-day versus two-day cleansing for colon capsule endoscopy: a prospective randomized pilot study显示文摘 | Laura Ramos Onofre Alarcón Zaida Adrian Antonio Z. Gimeno-García David Nicolás-Pérez Alejandro Jiménez-Sosa Enrique Quintero | 2013 | Gastroenterologia y Hepatologia2013，，： | 2 |
| 4 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 5 | Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn’s disease显示文摘 | M.A. Rosillo M. Sanchez-Hidalgo A. Cárdeno C. Alarcón de la Lastra | 2011 | Biochemical Pharmacology2011，，7： | 2 |
| 6 | Endogenous human microRNAs that suppress breast cancer metastasis显示文摘 | Tavazoie SF Alarc(o)n C Oskarsson T | 2008 | Nature2008，451，7175： | 1 |
| 7 | Simulation and evaluation of the coupling of desalination units to parabolic-trough solar power plants in the Mediterranean region显示文摘 | Patricia Palenzuela Guillermo Zaragoza Diego Alarcón Julián Blanco | 2011 | Desalination2011，281，： | 1 |
| 8 | Characterization of digestive enzyme activity during larval development of gilthead seabream(Sparus aurata)显示文摘 | Moyano FJ Díaz M Alarcón FJ | 1996 | Fish Physiol Biochem1996，15，2： | 1 |
| 9 | Mechanism of crystallization of Co-cordierites from stoichiometric powdered glasses显示文摘 | Maria Angeles Villegas Javier Alarcón | 2002 | Journal of the European Ceramic Society2002，，： | 1 |
| 10 | Pseudomonas syringae phytotoxins:mode of action,regulation,and biosynthesis by peptide and polyketide synthetases显示文摘 | Bender Cl Alarcón-Chaidez F Cross Dc | 1999 | Micro Mole Biol Rev1999，63，2： | 1 |
| 11 | Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008显示文摘 | J. López-Miranda F. Pérez-Jiménez E. Ros R. De Caterina L. Badimón M.I. Covas E. Escrich J.M. Ordovás F. Soriguer R. Abiá C. Alarcón de la Lastra M. Battino D. Corella J. Chamorro-Quirós J. Delgado-Lista D. Giugliano K. Esposito R. Estruch J.M. Fernandez- | 2009 | Nutrition Metabolism and Cardiovascular Diseases2009，，4： | 1 |
| 12 | Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model显示文摘 | Ana Beatriz Albino de Almeida Marina Sánchez-Hidalgo Antonio Ramón Martín Anderson Luiz-Ferreira José Roberto Trigo Wagner Vilegas Lourdes Campaner dos Santos Alba Regina Monteiro Souza-Brito Catalina Alarcón de la Lastra | 2013 | Journal of Ethnopharmacology2013，，1： | 1 |
| 13 | General Practitioners’ Knowledge, Attitudes, Beliefs, and Practices in the Management of Sexual Dysfunction—Results of the Portuguese SEXOS Study显示文摘 | Violeta Alarc?o Sofia Ribeiro Filipe Le?o Miranda Mário Carreira Teresa Dias Joaquim Garcia e Costa Alberto Galv?o‐Teles | 2012 | The Journal of Sexual Medicine2012，，： | 1 |
| 14 | Endogenous human microRNAs that suppress breast cancer metastasis显示文摘 | Tavazoie SF Alarcón C Oskarsson T | 2008 | Nature2008，451，7175： | 1 |
| 15 | LIP 394 for the prevention of renal flare in patients with systemic lupus erythematosus: results from a randomized, double-blind, placebo- controlled study 显示文摘 | Alarc n-Segovia D Tumlin JA Furie RA | 2003 | Arthritis Rheum2003，48，2： | 1 |
| 16 | Linkage,association,and gene-expression analyses identify CNTNAP2 as an autism-susceptihility gene显示文摘 | Alarcón M Abrahams BS Stone JL Duvall JA Perederiy JV Bomar JM | | 0，，01： | 1 |
| 17 | Crammed signaling motifs in the T-cell receptor显示文摘 | Borroto A Abia D Alarcón B | 2014 | Immunol Lett2014，161，1： | 1 |
| 18 | Mineralogical composition of African dust delivered by red rains over northeastern Spain 显示文摘 | Avila A Queralt-Mitjans I Alarcón M | 1997 | Journal of Geophysical Research1997，102，21： | 1 |
| 19 | Endogenous humanmicroRNAs that suppress breast cancer metastasis显示文摘 | Tavazoie SF Alarcón C Oskarsson T | 2008 | Nature2008，451，7175： | 1 |
| 20 | Traumatic rupture of the diaphragm显示文摘 | Cerón Navarro J Pe¨nalver Cuesta J C Padilla Alarcón J | 2008 | Arch Bronconeumol2008，44，： | 1 |
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