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| 1 | Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma显示文摘Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma(HCC).HCC develops over several decades and is associated with fibrosis.This sequence suggests that persistent viral infection and chronic inflammation can synergistically induce liver fibrosis and hepatocarcinogenesis.The transforming growth factor-β(TGF-β) signaling pathway plays a pivotal role in diverse cellular processes and contributes to hepatic fibro-carcinogenesis under inflammatory microenvironments during chronic liver diseases.The biological activities of TGF-β are initiated by the binding of the ligand to TGF-β receptors,which phosphorylate Smad proteins.TGF-β typeⅠreceptor activates Smad3 to create COOH-terminally phosphorylated Smad3(pSmad3C),while pro-inflammatory cytokine-activated kinases phosphorylates Smad3 to create the linker phosphorylated Smad3(pSmad3L).During chronic liver disease progression,virus components,together with pro-inflammatory cytokines and somatic mutations,convert the Smad3 signal from tumor-suppressive pS-mad3C to fibro-carcinogenic pSmad3 L pathways,accelerating liver fibrosis and increasing the risk of HCC.The understanding of Smad3 phosphorylation profiles may provide new opportunities for effective chemoprevention and personalized therapy for patients with hepatitis virus-related HCC in the future. | Miki Murata Katsunori Yoshida Takashi Yamaguchi Koichi Matsuzaki | 2014 | World Journal of Gastroenterology2014，20，41： | 5 |
| 2 | ASPP2表达对食管癌术后疗效评价意义的研究显示文摘目的:探讨ASPP2在食管癌术后患者中的表达水平及意义,证实ASPP2对食管癌术后疗效评价的可行性。探讨ASPP2在食管癌组织转变过程中的分子作用机制,ASPP2表达与食管癌患者术后疗效的关系。方法:采用免疫组化方法检测45例食管癌、20例食管良性瘤及20例正常食管组织中ASPP2、P53的表达水平。进一步分析ASPP2、P53的表达与食道癌临床病理特征的关系。采用Spearman等级相关的方法,对ASPP2、P53的表达水平进行相关性分析。结果:三组标本组织中ASPP2、P53的表达水平比较P<0.05,具有显著性差异。结论:食管癌组织中ASPP2表达显著下降,P53水平明显增高,ASPP2、P53的表达与食管癌的直径侵袭和淋巴结转移有关,ASPP2、P53的异常表达是食管癌发生和发展的重要因素,ASPP2是判断食管癌术后疗效的较好指标。 | 李东 田洪超 李树臣 牛凤英 殷培伟 | 2015 | 大家健康(学术版)2015，，3： | 1 |
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