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| 1 | 人类面临的甲基汞暴露和健康影响:世界范围的关注显示文摘本文基于现有的文献资料,突出了当前的认识并且识别在甲基汞暴露、健康影响、危害评估方面还未解决的问题并且得出意见一致的结论。甲基汞是一种烈性毒素,通过水中的食物链在生物体内积累和富集,使世界各地各种社会经济阶层内那些常吃食肉鱼类或者以鱼类为主食的人置于危险境地。甲基汞对神经的发育危害已经成为制定风险评估和公共健康政策的基础。尽管在暴露的新指示生物、影响甲基汞吸收和毒性的因素、毒物动力学、成年人神经病学和心脑血管的影响,来自大量海水鱼和淡水鱼以及食鱼鱼类的营养收益和危害,各方面的知识还有许多研究断层,研究小组认为要保护人类健康,必须尽一切努力来减少并消除暴露源。 | Donna Mergler Henry A.Anderson Laurie Hing Man Chan Kathryn R.Mahaffey Michael Murray Mineshi Sakamoto Alan H.Stern 甲基汞的健康风险和毒物学影响专家组 | 2007 | AMBIO-人类环境杂志2007，36，1： | 12 |
| 2 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 3 | 陈幼坚访谈著名设计师韩家英显示文摘韩家英1961年出生于天津;1982年入读西安美术学院工艺系装潢专业;1986年毕业后任教于西北纺织学院服装系;1990年入深圳万科文化传播公司,任设计总监;1993年成立深圳市韩家英设计有限公司。主要设计奖项及活动:1995年克罗地亚举行的第七届zgraf国际平面设计展[佳作奖];1995年[深圳最佳工业设计奖];1 995年香港亚太区[设计96展]银奖及优异奖等四项奖;1996年[平面设计在中国展]评审奖、金、银、铜及优异奖等十三项奖;1 998年香港[设计98展]银奖及优异奖等五项奖;1998年第五届墨西哥国际海报双年展[Jose-Guadalupe Posads]金奖;1998年应邀赴香港出任特许设计师协会香港98设计年展评委;1998年应德田柏林人剧团及设计师协会VGD邀请,参加了为纪念布莱希特100周年诞辰举办的全世界100名设计师的海报创作活动;1 999年应邀参加第十一届美国科罗拉多国际海报邀请展;1999年应邀参加韩国东亚细亚文字艺术展;2000年[香港设计2000展]金奖;2000年第六届日本富山国际海报三年展铜奖; 2000年波兰旺达计算机艺术双年展二等奖;2000年第十九届捷克布尔诺国际平面设计双年展荣誉奖;2001年作品被德国Kunst und Gewerbe Hamburg博物馆永久收藏。2001年应邀参加法田巴黎国立密特朗图书馆举办的[平面设计200人.1997-2000]展应邀参? | ALAN CHAN | 2003 | 新材料·新装饰2003，1，8： | 4 |
| 4 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 5 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 6 | Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging显示文摘坏死是仅仅在象 ischemic 疾病和创伤的大脑损害(TBI ) 那样的病理学的条件下面发生的房间死亡的一种形式。影响组织的非侵略的成像是新奇治疗学的干预的一个关键部件和在病人的治疗回答的测量。这里,我们为察觉报导一条 bimodal 途径并且 TBI 监视。PEGylated poly (lactic-co-glycolic 酸)(PLGA ) nanoparticles (NP ) ,包含两个近红外线(NIR ) fluorophores 和 perfluorocarbons (陆军) ,被指向到坏死的房间。我们使用了象 IRDye 800CW,我们以前为表明了到失去了膜正直的房间的细胞内部的蛋白质的特定的指向那样的花青染料。这里,我们出现在由光成像和氟的符号的坏死的 vivo 察觉特定磁性的回声成像(19 F MRI ) 用最新设计的 PLGA NP (NIR700 + 陆军)-PEG-800CW。量的前 vivo 光成像和 19 在受伤大脑区域并且在主要机关的 NIR 陆军内容的 F 先生光谱学很好被相关。允许的两种形式在里面在 TBI 的一个老鼠模型的坏死的大脑损害的 vivo 鉴定,与比 19 F MRI。我们的结果证实与木钉层并且损坏 TBI 的织物的成功的指向涂的 PLGA NP 的增加的血水池住处时间。包含 NIR 陆军的单个 PLGA NP 启用两个快速由 MRI 的在损害的程度上的从更深的纸巾的 TBI 州、量的 3D 信息的质的光监视。这些指向坏死的 PLGA NP 能潜在地被用于大脑损害的临床的诊断。 | Luis Javier Cruz Ivo Que Markus Aswendt Alan Chan Mathias Hoehn Clemens Lowik | 2016 | Nano Research2016，9，5： | 3 |
| 7 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 3 |
| 8 | EPCA-2: A Highly Specific Serum Marker for Prostate Cancer显示文摘 | Eddy S. Leman Grant W. Cannon Bruce J. Trock Lori J. Sokoll Daniel W. Chan Leslie Mangold Alan W. Partin Robert H. Getzenberg | 2007 | Urology2007，，4： | 1 |
| 9 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 1 |
| 10 | Emergence in China of human disease due to avian influenza A(H10N8)-cause for concern显示文摘 | To K K Tsang A K Chan J F Kelvin K W Alan K L | 2014 | J Infect2014，68，： | 1 |
| 11 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 1 |
| 12 | Inhibition of Human Sperm Motility by Specific Herbs Used in Alternative Medicine显示文摘 | Richard R. Ondrizek Philip J. Chan William C. Patton Alan King | 1999 | Journal of Assisted Reproduction and Genetics1999，，2： | 1 |
| 13 | Insecticidal activities of asarones identified in Acorus gramineusrhizome against Nilaparvata lugens (Homoptera: Delphacidae) and Plutella xylostella(Lepidoptera: Yponomeutoidae)显示文摘 | Hee Kwon Lee Chan Park Young Joon Alan | 2002 | Applied Entomology and Zoology2002，37，3： | 1 |
| 14 | Complexed prostate-specific antigen as a staging tool: results based on a multicenter prospective evaluation of complexed prostate-specific antigen in cancer diagnosis显示文摘 | Samir S Taneja Elias I Hsu Carol D Cheli Paul Walden Georg Bartsch Wolfgang Horninger Richard J Babaian Herbert A Fritsche Stacy Childs Thomas A Stamey Lori J Sokoll Daniel W Chan Michael K Brawer Alan W Partin Herbert Lepor | 2002 | Urology2002，，4： | 1 |
| 15 | Complexed prostate-specific antigen as a staging tool for prostate cancer: a prospective study in 420 men显示文摘 | Lori J Sokoll Leslie A Mangold Alan W Partin Jonathan I Epstein Debra J Bruzek Willard Dunn Phaedre Mohr Gail Wallerson Daniel W Chan | 2002 | Urology2002，，4： | 1 |
| 16 | Effects of sign characteristics and training methods on safety sign training effectiveness显示文摘 | Alan H S Chan Annie W Y Ng | 2010 | Ergonomics2010，53，11： | 1 |
| 17 | THE USE OF PERCENT FREE PROSTATE SPECIFIC ANTIGEN FOR STAGING CLINICALLY LOCALIZED PROSTATE CANCER显示文摘 | JURGEN PANNEK HARRY G. RITTENHOUSE DANIEL W. CHAN JONATHAN I. EPSTEIN PATRICK C. WALSH ALAN W. PARTIN | 1998 | The Journal of Urology1998，，4： | 1 |
| 18 | Usefulness ofthe MiNi nutritional assessment in predicting the nutritional status ofpatients with liver cancer in taiwar显示文摘 | Alan CT Wei-Chung Hsu Shu-Ching Chan | 2011 | Nutrition and Cancer2011，63，3： | 1 |
| 19 | Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients显示文摘 | Thomas S. Y. Chan Harinder Gill Yu-Yan Hwang Joycelyn Sim Alan C. T. Tse Florence Loong Pek-Lan Khong Eric Tse Anskar Y. H. Leung Chor-Sang Chim Albert K. W. Lie Yok-Lam Kwong | 2014 | Annals of Hematology2014，，3： | 1 |
| 20 | Emergence in China of human disease due to avian influenza A(H10N8) – Cause for concern?显示文摘 | Kelvin K.W. To Alan K.L. Tsang Jasper F.W. Chan Vincent C.C. Cheng Honglin Chen Kwok-Yung Yuen | 2014 | Journal of Infection2014，，3： | 1 |
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