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| 1 | T2* magnetic resonance imaging of the liver in thalassemic patients in Iran显示文摘AIM: To investigate the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. METHODS: In this cross-sectional study, 210 patients with beta-thalassemia major having regular blood transfusions were consecutively enrolled. Serum ferritin levels were measured, and all patients underwent MRI T2* of the liver. Liver biopsy was performed in 53 patients at an interval of no longer than 3 mo after the MRIT2* in each patient. The amount of iron was assessed in both MRI T2* and liver biopsy specimens of each patient. RESULTS: Patients’ ages ranged from 8 to 54 years with a mean of 24.59 ± 8.5 years. Mean serum ferritin level was 1906 ± 1644 ng/mL. Liver biopsy showed a moderate negative correlation with liver MRI T2* (r = -0.573, P = 0.000) and a low positive correlation with ferritin level (r = 0.350, P = 0.001). Serum ferritin levels showed a moderate negative correlation with liver MRI T2* values (r = -0.586, P = 0.000). CONCLUSION: Our study suggests that MRI T2* is a non-invasive, safe and reliable method for detecting iron load in patients with iron overload. | Farhad Zamani Sara Razmjou Shahram Akhlaghpoor Seyyedeh-Masoomeh Eslami Azita Azarkeivan Afsaneh Amiri | 2011 | World Journal of Gastroenterology2011，17，4： | 8 |
| 2 | Randomized placebo‐controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis显示文摘 | Mehdi Mohamadnejad Kamran Alimoghaddam Mohammad Bagheri Mandana Ashrafi Leila Abdollahzadeh Shahram Akhlaghpoor Maryam Bashtar Ardeshir Ghavamzadeh Reza Malekzadeh | 2013 | Liver Int2013，，10： | 3 |
| 3 | Tracheobronchial stenosis following sulfur mustard inhalation显示文摘 | Ghanei M Akhlaghpoor S Moahammad MM | 2004 | Inhal Toxicol2004，16，13： | 1 |
| 4 | Diagnostic perfor- mance of 64-channel multislice computed tomography in assess- ment of significant coronary artery disease in symptomatic sub- jects显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，12： | 1 |
| 5 | Complementary effect of H MRS in diagnosis of suprasellar tumors显示文摘 | Morteza Faghih Jouibari Seyed Mohammad Ghodsi Shahram Akhlaghpoor Masoud Mehrazin Soheil Saadat Alireza Khoshnevisan Tahereh Padeganeh Ahmad Aoude | 2012 | Clinical Imaging2012，，6： | 1 |
| 6 | Percu taneous Osteoid Osteoma Treatment with Combination of Radiofrequency and Alcohol Ablation显示文摘 | Akhlaghpoor S Tomasian A Arjmand Shabestari A | 2007 | Clin Radiol2007，62，3： | 1 |
| 7 | Comparison of virtual bronehoseopy with fiberoptic bronchoscopy findings in pa- tients exposed to sulfur mustard gas显示文摘 | Akhlaghpoor S Ahari AA Shabestari AA | 2011 | Acta Radiologica2011，52，10： | 1 |
| 8 | Comparison of virtual bronchoseopy with fiberoptie bronchoseopy findings in patients exposed to sulfur mustard gas显示文摘 | Akhlaghpoor S Ahafi AA Shabestari AA | 2011 | Aeta Radiologica2011，52，10： | 1 |
| 9 | Diagnostic performance of 64-channel multislice computed tomography in assessment of significant coronary artery disease in symptomatic subjects显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，： | 1 |
| 10 | Comparison of virtual bron- choseopy with fiberoptie bronehoseopy findings in patients exposed to sulfur mustard gas显示文摘 | Akhlaghpoor S Ahari AA Shabestari AA | 2011 | Aeta Radiologiea2011，52，10： | 1 |
| 11 | Diagnostic performance of 64- channel multislic e computed tomography in assessment of significant coronatry artery, disease in symptomatic subjects 显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，12： | 1 |
| 12 | Diagnostic performance of 64-channel multislice computed tomography in assessment of significant coronary artery disease in symptomatic subjects 显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，： | 1 |
| 13 | Quantitative T2* magnetic resonance imaging for evaluation of iron deposition in the brain of β-thalassemia patients显示文摘 | Akhlaghpoor S Ghahari A Morteza A | 2012 | Clin Neuroradiol2012，22，3： | 1 |
| 14 | Complementary effect of H MRS in diagnosis of suprasellar tumors显示文摘 | Faghih J M Ghodsi S M Akhlaghpoor S | 2012 | Clin Ima- ging2012，3，6： | 1 |
| 15 | Prevalence of congenital coronary artery anomalies and variants in 2697 consecutive patients using 64-detector row coronary etangiography 显示文摘 | Shabestari AA Akhlaghpoor S Tayebivaljozi R | 2012 | Iran J Radiol2012，9，3： | 1 |
| 16 | Diagnostic performance of 64-channel multislice computed tomography in assessment of significant coronary artery disease in symptomatic subjects显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，12： | 1 |
| 17 | Diagnostic performance of 64-channel muhislice computed tomo- graphy in assessment of significant coronary artery disease in symptomatic subjects显示文摘 | Shabestari AA Abdi S Akhlaghpoor S | 2007 | Am J Car- diol2007，99，12： | 1 |
| 18 | Diagnostic performance of 64-ehannelmultislice computed tomography in assessment of significant coronary artery disease in symptomatic subjects显示文摘 | Shabestari A A Abdi S Akhlaghpoor S | 2007 | Am J Cardiol2007，99，12： | 1 |
| 19 | Short-term effectiveness of radiochemoembolization for selected hepatic metastases with a combination protocol显示文摘AIM:To introduce the combination method of radio-chemoembolization for the treatment of selected hepatic metastases. METHODS:Twenty patients with biopsy proven hepatic metastases were selected from those who underwent transarterial radiochemoembolization, a novel combination protocol, between January 2009 and July 2010. Patients had different sources of liver metastasis. The treatment included transarterial administration of three chemotherapeutic drugs (mitomycin, doxorubicin and cisplatin), followed by embolization with large (50-150 μm) radioisotope particles of chromic 32P. Multiphasiccomputer tomography or computer tomography studies, with and without contrast medium injections, were performed for all patients for a short-term period before and after the treatment sessions. The short-term effec-tiveness of this procedure was evaluated by modified response evaluation criteria in solid tumors (mRECIST), which also takes necrosis into account. The subjective percentage of necrosis was also assessed. The response evaluation methods were based on the changes in size, number, and the enhancement patterns of the lesions between the pre-and post-treatment imaging studies. RESULTS:Patients had liver metastasis from colorectal carcinomas, breast cancer, lung cancer and carcinoid tumors. The response rate based on the mRECIST criteria was 5% for complete response, 60% for partial response, 10% for stable disease, and 25% for progressive disease. Regarding the subjective necrosis percentage, 5% of patients had complete response, 50% had partial response, 25% had stable disease, and 20% had progressive disease. Based on traditional RECIST criteria, 3 patients (15%) had partial response, 13 patients (65%) had stable disease, and 4 patients (20%) had disease progression. In most patients, colorectal carcinoma was the source of metastasis (13 patients). Based on the mRECIST criteria, 8 out of these 13 patients had partial responses, while one remained stable, and 5 showed progressive disease. We also had 5 cases of breast cancer metastasis which mostly remained stable (4 cases), with only one partial response after the procedure. Six patients had bilobar involvement; three of them received two courses of radiochemoembolization. The follow up imaging study of these patients was performed after the second ses-sion. In the studied patients there was no evidence of extrahepatic occurrence, including pulmonary radioac-tive deposition, which was proven by Bremsstrahlung scintigraphy performed after the treatment sessions. For the short-term follow-ups for the 2 mo after the therapy, no treatment related death was reported. The mostly common side effect was post-embolizationsyndrome, presented as vomiting, abdominal pain, and fever. Nineteen (95%) patients experienced this syndrome in different severities. Two patient had ascites (with pleural effusion in one patient) not related to hepatic failure. Moreover, no cases of acute liver failure, hepatic infarction, hepatic abscess, biliary necrosis, tumor rupture, surgical cholecystitis, or non-targeted gut embolization were reported. Systemic toxicities such as alopecia, marrow suppression, renal toxicity, or cardiac failure did not occur in our study group. CONCLUSION:Radiochemoembolization is safe and effective for selected hepatic metastases in a short-term follow-up. Further studies are required to show the long-term effects and possible complications of this approach. | Shahram Akhlaghpoor Alireza Aziz-Ahari Mahasti Amoui Shahnaz Tolooee Hossein Poorbeigi Shahab Sheybani | 2012 | World Journal of Gastroenterology2012，18，37： | 1 |
| 20 | Detection and Severity Scoring of Chronic Obstructive Pulmonary Disease Using Volumetric Analysis of Lung CT Images显示文摘 | Hosseini MP Soltanian-Zadeh H Akhlaghpoor S | 2012 | Iran J Radiol2012，9，1： | 1 |
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