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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Enhanced expression and activity yields of Clostridium thermocellum xylanases without non-catalytic domains显示文摘 | Sajjad M Khan I M Akbar N S | | 0，，1： | 1 |
| 3 | Correlation between branched chain amino acids to tyrosine ratio and child pugh score in liver cirrhosis patients显示文摘 | Hasan I A Gani R Akbar N | | 0，，01： | 1 |
| 4 | Modelling of non-uniform DC driven glow discharge in argon gas显示文摘 | Rafatov I R Akbar D Bilikmen S | 2007 | Physics Letters A2007，367，12： | 1 |
| 5 | Acoustic rhinometry and computed tomography scans for the diagnosis of nasal septal deviation, with clinical correlation显示文摘 | Mamikoglu B Houser S Akbar I | 2000 | Otolaryngol Head Neck Surg2000，123，11： | 1 |
| 6 | Frequency of renal stone disease in patients with urinary tract infection 显示文摘 | Jan H Akbar I Kamran H | 2008 | J Ayub Med Coil Abbottabad2008，20，1： | 1 |
| 7 | Land subsidence of Jakarta (Indonesia) and its geodetic monitoring system显示文摘 | Abidin H Z Djaja R Darmawan D Hadi S Akbar A Rajiyowiryono H Sudibyo Y Meilano I Kasuma M A Kahar J Subarya C | 2001 | Natural hazards2001，23，23： | 1 |
| 8 | Modelling of non-uniform DC driven glow discharge in argon gas显示文摘 | Rafatov I R Akbar D Bilikmen S | 2007 | Physics Letters A2007，367，1： | 1 |
| 9 | Flare--up rate in molars with periapical radiolucency in one- visit vs two- visit endodontic treatment显示文摘 | Akbar I Iqbal A Al--Omiri MK | 2013 | J Contemp Dent Pract2013，14，3： | 1 |
| 10 | Modelling of Non-Uniform DC Driven Glow Discharge in Argon Gas显示文摘 | Rdatov I R Akbar D Bilikmen S | | 0，，1： | 1 |
| 11 | Complications of in-dwelling venous access device:a single institution experience显示文摘 | BURNEY I A KHURSHALDI N AKBAR M T | 2001 | J Pak Med Assoc2001，51，： | 1 |
| 12 | Complications of in-dwelling venous access device: a single institution experience显示文摘 | BURNEY I A KHURSHALDI N AKBAR M T | 2001 | J Pak Med Assoc2001，51，： | 1 |
| 13 | Estimating rural households' willingness to pay for health insurance显示文摘 | A li Asgary Ken Willis Ali Akbar Taghvae i Mojtaba Rafeian | | 0，，05： | 1 |
| 14 | Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease显示文摘 | Song B J Akbar M Jo I | 2015 | Adv Pharmacol2015，74，： | 1 |
| 15 | Modelling of non-uniform DC driven glow discharge in argon gas显示文摘 | RAFATOV I R AKBAR D BILIKMEN S | 2007 | Physics Letters: A2007，367，12： | 1 |
| 16 | Outcome of fixateur interne in thoracolumbar trauma显示文摘 | Rehman L Khattak A Akbar I | 2010 | J Ayub Med Coll Abbottabad2010，22，1： | 1 |
| 17 | Flare-up rate in molars with periapieal radioluceney in one-visit vs two-visit endodontie treatment 显示文摘 | Akbar I Iqbal A A1-Omiri MK | 2013 | J Cont- emp Dent Pract2013，14，3： | 1 |
| 18 | Job involvement as predictor of employee commitment: Evidence from Pakistan显示文摘 | Khan T I Jam F A Akbar A | 2011 | International Journal of Business and Mana- gement2011，6，4： | 1 |
| 19 | Diffusion welding of OFHC copper to austenitic stainless steel 316L显示文摘 | KHEDER A R I AKBAR A A JUBEH N M | 2004 | International Journal for the Joining of Materials2004，16，4： | 1 |
| 20 | Modelling of Non-Uniform DC Driven Glow Discharge in Argon Gas显示文摘 | Rafatov I R Akbar D Bilikmen S | 2007 | Physics Letters2007，367，： | 1 |
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