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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Prolactin release in cattle 显示文摘 | Akbar H Schams D | 1974 | J Reprod and Fert1974，39，： | 1 |
| 3 | Assessment of Scenic Beauty of the Roadside Vegetation in Northern England显示文摘 | Akbar K F Hale W H G Headley A D | 2003 | Landscape and Urban Planning2003，，63： | 1 |
| 4 | Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain 显示文摘 | Finney H M Akbar A N Lawson A D | 2004 | J Immunol2004，172，1： | 1 |
| 5 | Cattle dung pat microenvironmental effects on germination and establishment on crested wheatgrass显示文摘 | Akbar G Call C A Wiedmeier R D | 1995 | Soil Research1995，，： | 1 |
| 6 | Microwave dielectric properties of doped BaTi4O9显示文摘 | Mhaisalker S G Readey D W Akbar S A | | 0，，08： | 1 |
| 7 | Direct numerical method for an inverse problem of a parabolic parical differential equation显示文摘 | Liao Wenyuan Mehdi D Akbar M | 2009 | Journal of Computational and Applied Mathematics2009，3232，： | 1 |
| 8 | Infared reflectance spectra of doped BaTi4O9 显示文摘 | Mhaisalkar S G Readey D W Akbar S A | 1991 | Solid State Chem1991，95，： | 1 |
| 9 | On gas-liquid two-phase flow regimes in microchannels 显示文摘 | Akbar M K Plummer D A Ghiaasiaan S M | 2003 | Int J Multiphase Flow2003，29，5： | 1 |
| 10 | On gas-liquid two-phase flow regimes in microchannel显示文摘 | AKBAR M K PLUMMER D A GHIAASIAAN S M | 2003 | International Journal of Multiphase Flow2003，29，5： | 1 |
| 11 | On gas-liquid two phase flow regimes in microchannels显示文摘 | Akbar MK Plummer D A Ghiaasiaan S M | | 0，，： | 1 |
| 12 | Effect of mefformin and sulfonylurea on C - reactive protein level in well - controlled type 2 diabetics with metabolic syndrome显示文摘 | | 2003 | Endocrine2003，20，3： | 1 |
| 13 | Infrared reflectance spectra of doped BaTi4 O9显示文摘 | MHAISALKAR S G READEY D W AKBAR S A | 1991 | J Solid State Chem1991，95，： | 1 |
| 14 | Assessment of scenic beauty of the roadside vegetation in northern England显示文摘 | Akbar K F Hale W H G Headlev A D | | 0，，02： | 1 |
| 15 | Effect of Metformin and Sulfonylurea on C-reactive Protein Level in Well-controlled Type 2 Diabetics with Metabolic Syndrome显示文摘 | Akbar D H | 2003 | Endocrine2003，20，3： | 1 |
| 16 | Regulatory T cells in human disease and their potential for therapeutic manipulation显示文摘 | TAAMS L S PALMER D B AKBAR A N | 2006 | Immunology2006，118，： | 1 |
| 17 | Frequency and correlation of molecular subtypes of breast cancer with clinicopathological features 显示文摘 | Akbar M Akbar K Naveed D | 2014 | J Ayub Med Coil Abbottabad2014，26，3： | 1 |
| 18 | Direct solubilization of enzyme aggregates with enhanced activity in nonaqueous media 显示文摘 | AKBAR U ASCHENBRENNER C D HARPER M R | 2007 | Biotechnol Bioeng2007，96，6： | 1 |
| 19 | Assessment of scenic beauty of the roadside vegetation in northern England显示文摘 | Akbar K F Hale W H G Headley A D | 2003 | Landscape and Urban Planning2003，63，： | 1 |
| 20 | Modelling of non-uniform DC driven glow discharge in argon gas显示文摘 | Rafatov I R Akbar D Bilikmen S | 2007 | Physics Letters A2007，367，12： | 1 |
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