|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | 黄铜矿精矿在甘氨酸介质中的循环伏安及动电位极化研究显示文摘采用循环伏安及动电位极化方法研究黄铜矿在甘氨酸介质中的浸出反应机理及动力学。使用黄铜精矿−碳糊电极研究pH值(9~12),温度(30~90)及甘氨酸浓度(0~2 mol/L)对腐蚀电流密度、腐蚀电位及循环伏安曲线的影响。结果显示,甘氨酸浓度从0增加到2 mol/L导致氧化峰电流密度增加;在相同条件下,腐蚀电流密度从约28μA/cm2增加至约89μA/cm2,同时腐蚀电位由−80 mV降至−130 mV。在温度不高于60℃的条件下,电流密度随温度的增加而增加;当温度高于60℃时,电流密度随温度增加而降低。电流密度随pH值的变化与温度相似,当pH值从9增至10.5时电流密度增加,pH值高于10.5时电流密度降低。此外,铜氧化物及铁氧化物的热力学稳定性在较高温度下增加。 | Maryam KHEZRI Bahram REZAI Ali Akbar ABDOLLAHZADEH Benjamin PWILSON Mehdi MOLAEINASAB Mari LUNDSTRÖM | 2021 | Transactions of Nonferrous Metals Society of China2021，31，2： | 3 |
| 3 | Heuristic solutions for the multiple-choice multi-dimension knapsack problem显示文摘 | Akbar M M Manning E G Shoja G C | 2001 | Lecture Notes in Computer Science2001，2074，2： | 1 |
| 4 | Dendritic cells with immature phenotype and defective function in the peripheral blood from patients with hepatocellular carcinoma显示文摘 | Ninomiya T Akbar S M Masamoto T | 1999 | J Hepatol1999，131，2： | 1 |
| 5 | Serum levels of follicl-stimulating hormone during the bovine estrous cycle 显示文摘 | Akbar A M Reichert L E Jr Dunn T G Jr | 1974 | J Anim Sci1974，39，： | 1 |
| 6 | Mecha- nism of action of vaccine therapy in murine hepatitis B virus carriers: vaccine - induced activation of antigen presenting dendritic cells显示文摘 | Akbar SM Abe M Masumoto T | 1999 | J Hepatol1999，30，5： | 1 |
| 7 | Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival显示文摘 | Akbar M Calderon F Wen Z | 2005 | Proc Natl Acad Sci U S A2005，102，10： | 1 |
| 8 | Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis显示文摘 | Abe M Akbar F Hasebe A | 2003 | J Gastroenterol2003，38，10： | 1 |
| 9 | Growth curve analyses in selected duck lines 显示文摘 | Maruyama K Vinyard B Akbar M K | 2001 | British Poultry Science2001，42，5： | 1 |
| 10 | Solving the multidimensional multiple-choice knapsack problem by constructing convex hulls 显示文摘 | Akbar M M Rahman M S Kaykobaad M | 2005 | Computers & Operations Research2005，33，5： | 1 |
| 11 | Noninvasive diagnosis of the de- gree of hepatic fibrosis using uhrasonography in patients with chronic liver disease due to hepatitis C virus 显示文摘 | Hirala M Akbar SM Horuke N | 2001 | Eur J Clin Invest2001，31，6： | 1 |
| 12 | Investigation of the mechanismof chlorination of glyphosate and glycine in water显示文摘 | AKBAR M MARIAN B STEPHAN B | 2006 | Water Research2006，40，： | 1 |
| 13 | Effect of ambient temperature on the performance of contamination DC insulators显示文摘 | Ishii M Akbar M Kawamura T | 1984 | IEEE Trans actions on Electrical Insulation1984，19，2： | 1 |
| 14 | Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain 显示文摘 | Finney H M Akbar A N Lawson A D | 2004 | J Immunol2004，172，1： | 1 |
| 15 | Growth pattern and carcase development in male ducks selected for growth rate显示文摘 | Maruyama K Akbar M K Turk C M | 1999 | Br Poult Sci1999，40，： | 1 |
| 16 | Production antibody to hepatitis B surface antigen (anti-HBs) by marine hepatitis B virus neonal tolerance versus antigen presentation by dendritic cells显示文摘 | Akbar S M Yamamoto K | 1997 | Inmmology1997，92，4： | 1 |
| 17 | Hepatitis B virus (HBV)-transgenic mice as an investigative tool to study immunopathology during HBV infection 显示文摘 | Akbar SK Onji M | 1998 | Int J Exp Pathol1998，79，： | 1 |
| 18 | Automatic implantable cardioverter defibrillator for the treatment of ventricular fibrillation following coronary artery spasm:a case report显示文摘 | AL-SAYEGH A SHUKKUR A M AKBAR M | 2007 | Angiology2007，58，1： | 1 |
| 19 | Safety and immuno- genicity of hepatitis B surface antigen-pulsed dendritic cells in patients with chronic hepatitis B显示文摘 | Akbar S M Furukawa S Horiike N | 2011 | J Viral Nepal2011，18，6： | 1 |
| 20 | Glycyrrhiziia enhances interleukin-10 production by liver dendritic cells in mice with hepatitis显示文摘 | Abe M Akbar F Hasebe A | 2003 | J Gastroenterol2003，38，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员