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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Beta titanium alloys in the 1990's显示文摘 | Ajit K M James A D Paul K | 1993 | Warrendale TMS1993，6171，： | 1 |
| 4 | Lead removal through biological sulfate reduction process显示文摘 | Tran T Warounsak L Ajit P A | 2007 | Bioresour Technol2007，98，13： | 1 |
| 5 | Impact of a FACTS controller on reliability of composite power genera- tion and transmission system显示文摘 | Verma Ajit Kumar Srividya A Deka Bimal C | 2004 | Electric Power Systems Research2004，72，2： | 1 |
| 6 | Web-based security cost analysis in electricity markets 显示文摘 | CHEN H CLAUDIO A C AJIT S | 2005 | IEEE Transactions on Power Systems2005，20，2： | 1 |
| 7 | A global perspective on the use, sales, exposure pathways, oc- currence, fate and effects of veterinary antibiotics (VAs) in the environment显示文摘 | Ajit K Sarmah Michael T Meyer Alistair B A Boxall | 2006 | Chemosphere2006，65，72： | 1 |
| 8 | Biological and chemical factors affecting the valuations of NorthEast Indian Plains teas(Ⅱ)显示文摘 | Biswas Ajit K Biswas Asim K Sarkar A R | 1971 | Sci Food Agric1971，22，： | 1 |
| 9 | Biological and chemical factors affecting the valuations of NorthEast Indian Plains teas(Ⅲ)显示文摘 | Biswas Ajit K Sarkar A R Biswas Asim K | 1973 | Sci Food Agric1973，24，12： | 1 |
| 10 | Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells显示文摘 | Ajit Lalvani Ansar A Pathan Helen Durkan Katalin A Wilkinson Adam Whelan Jonathan J Deeks William HH Reece Mohammed Latif Geoffrey Pasvol Adrian VS Hill | 2001 | The Lancet2001，，9273： | 1 |
| 11 | Z-MAC:A hybrid mac for wireless sensor networks显示文摘 | Injong R Ajit W Mahesh A et aI | 2008 | IEEE/ACM Trans Networks2008，16，3： | 1 |
| 12 | A global perspective on the use,sales,exposure pathways,occurrence,fate and effects of veterinary antibiotics (VAs) in the environment显示文摘 | AJIT K S MICHAEL T M ALISTAIR B A | 2006 | Chemosphere2006，65，： | 1 |
| 13 | A global perspective on the use, sales,exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment 显示文摘 | Ajit K S Michael T Meyer Alistair B A Boxall | 2006 | Chemosphere2006，65，5： | 1 |
| 14 | High Temperature Dynamic In-situ Raman Spectral Characterization of Sodium Borosilicate Glasses显示文摘 | Jillaven K Ajit C Robert A | 1993 | Materials Research Society Symposium Proceedings1993，321，： | 1 |
| 15 | In-situ Raman Spectral Characterization of Sodium Borosilicate Glasses at High Temperatures显示文摘 | Jillaven K Ajit C Robert A | 1994 | Canadian Ceramic Society1994，63，3： | 1 |
| 16 | Functional somatic complaints in depression: an overview 显示文摘 | KAUSTAV C AJIT A SANDEEP G et ol | 2010 | Asian J Psychiatr2010，3，3： | 1 |
| 17 | Clinical and prognostic features among children with acute encephalitis syndrome in Nepal: a retrospective study 显示文摘 | Ajit R Ireran A Elizabeth L | 2011 | BMC Infect Dis2011，11，： | 1 |
| 18 | Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy 显示文摘 | Ajit Bolar N Vanlander A V Wilbrecht C | 2013 | Hum Mol Genet2013，22，13： | 1 |
| 19 | Uncertainty analysis based on probability bounds (p-box) approach in probabilistic safety assessment 显示文摘 | Karanki D R Kushwaha H S Verma A K Ajit S | 2009 | Risk Analysis2009，29，5： | 1 |
| 20 | A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment显示文摘 | Ajit K S Michael T M Alistair B A | 2006 | Chemosphere2006，65，： | 1 |
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