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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Second Flow Velocity Patterns in a Pulmonary Artery Model with Varying Degrees of Valvular Pulmonic Stenosis: Pulsatile in Vitro Studies 显示文摘 | H W Sung Ajit P Yoganathan | 1990 | J Biomech Eng (SO 148-0731)1990，112，2： | 1 |
| 3 | Detecting Trichodesmium blooms in SeaWiFS imagery显示文摘 | AJIT Subramaniam CHRISTOPHER W Brown RALEIGH R Hood | 2002 | Deep-Sea Resereh: II2002，49，： | 1 |
| 4 | Does information technology lead to smaller firms? 显示文摘 | Erik Brynjolfsson Thomas W Malone Vijay Gurbaxani and Ajit Kambil | 1994 | Management Science1994，40，12： | 1 |
| 5 | Flocculation ofSerum Lipoproteins withCyclodextrins: application to assay of hy-perlipidemic serum显示文摘 | Ajit Sharma Karen Anderson and Jon W Baker | 1990 | Clin Chem1990，36，3： | 1 |
| 6 | New thermally remendable hig- hly cross-linked polymeric materials 显示文摘 | Chen X X Fred W Ajit K M | 2003 | Macromolecules2003，36，： | 1 |
| 7 | Z-MAC:A hybrid mac for wireless sensor networks显示文摘 | Injong R Ajit W Mahesh A et aI | 2008 | IEEE/ACM Trans Networks2008，16，3： | 1 |
| 8 | Flocculation, of SerumLipoproteins with cyclodextrins : application to assay of hyperlipidemicserum显示文摘 | AJit Sharma Karen Anderson and Jon W Baker | 1990 | Clin Chem1990，6，3： | 1 |
| 9 | Effect of braid angleon fatigue performance of biaxial braided composites显示文摘 | JITENDRA S T AJIT D K JOHN D W | 2006 | International Journal of Fatigue2006，28，10： | 1 |
| 10 | Analyses of homologous ratavirus infection in the mouse mode 显示文摘 | John W Burns Ajit A | 1995 | Virology1995，207，： | 1 |
| 11 | Leading Indicators of Innovation as a Competence for Individuals:An Empirical Study 显示文摘 | PRADEEP W MOHANTY R P AJIT V | 2011 | Journal of Advances in Management Research2011，8，2： | 1 |
| 12 | Comparison of implant related complications amongst patients with opioid use disorder and non-users following total knee arthroplasty显示文摘BACKGROUND The influence of opioid use disorder on implant related complications, infection and readmission rates, and total global episode-of-care costs following primary total knee arthroplasty(TKA) is limited.AIM To examine whether opioid abuse in patients undergoing primary TKA.METHODS A retrospective analysis of the Medicare dataset, using the PearlDiver database,from 2005-2014 comparing outcomes in patients with opioid abusers(OUD) to non-opioid abusers(NOU) undergoing primary TKA was performed. Patient outcomes were analyzed including implant complications, readmission rates, and day-of-surgery and 90-d cost. Statistical analysis was performed with R(University of Auckland, New Zealand) calculating odds-ratio(OR) along with their respective 95% confidence interval(95%CI) and P-values.RESULTS The OUD group was at greater odds of having implant related complications overall(20.84% vs 11.25%; OR: 2.07; 95%CI: 1.93-2.23; P < 0.001). Revision(OR:2.07; 95%CI: 1.11-3.84; P < 0.001), infection(OR: 1.92; 95%CI: 1.72–2.18; P < 0.001),periprosthetic fractures(OR: 1.83; 95%CI: 1.16-4.79; P < 0.001), and 90-dreadmission rates(OR: 1.47, 95%CI: 1.35-1.61, P < 0.001) were also significantly increased. OUD patients also incurred in higher day-of-surgery and total global 90-d episode-of-care costs compared to NOU.CONCLUSION Patients with OUD show an increased risk of complications compared to the nonopioid users group. Appropriate recognition, pre-surgical optimization, and patient education are essential to mitigate these complications and improve patient outcome. | Rushabh M Vakharia Karim G Sabeh Ajit M Vakharia Dhanur M Damodar Tsun Yee Law Martin W Roche | 2019 | World Journal of Orthopedics2019，10，3： | 0 |
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