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| 1 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications显示文摘 | Ajay Kumar Gupta Mona Gupta | 2004 | Biomaterials2004，，18： | 3 |
| 2 | Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate显示文摘Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract IIIM-160.Methods: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in Swiss albino mice.A suitable oral formulation was developed and characterized.Results: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in Swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in Sprague–Dawley rats.Conclusion: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation. | Sandip B.Bharate Vikas Kumar Sonali S.Bharate Bikarma Singh Gurdarshan Singh Amarinder Singh Mehak Gupta Deepika Singh Ajay Kumar Surjeet Singh Ram A.Vishwakarma | 2019 | Journal of Integrative Medicine2019，17，3： | 3 |
| 3 | Post‐transplant biliary complications: An analysis from a predominantly living donor liver transplant center显示文摘 | Manav Wadhawan Ajay Kumar Subash Gupta Neerav Goyal Rajeev Shandil Sunil Taneja Anupam Sibal | 2013 | J Gastroenterol Hepatol2013，，6： | 1 |
| 4 | Synthesis and surface en- gineering of iron oxide nano-particles for biomedical appli- cations显示文摘 | Ajay Kumar Gupta Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 5 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications显示文摘 | Ajay Kumar Gupta Mona Gupta | 2004 | Biomaterials2004，，18： | 1 |
| 6 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications 显示文摘 | Ajay Kumar Gupta Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 7 | Gene networks in hexaploid wheat: interacting quantitative trait loci for grain protein content显示文摘 | Pawan Kulwal Neeraj Kumar Ajay Kumar Raj Kumar Gupta Harindra Singh Balyan Pushpendra Kumar Gupta | 2005 | Functional & Integrative Genomics2005，，4： | 1 |
| 8 | QTL analysis for some quantitative traits in bread wheat显示文摘Quantitative trait loci (QTL) analysis was conducted in bread wheat for 14 important traits utilizing data from four different mapping populations involving different approaches of QTL analysis. Analysis for grain protein content (GPC) sug- gested that the major part of genetic variation for this trait is due to environmental interactions. In contrast, pre-harvest sprouting tolerance (PHST) was controlled mainly by main effect QTL (M-QTL) with very little genetic variation due to environmental interactions; a major QTL for PHST was detected on chromosome arm 3AL. For grain weight, one QTL each was detected on chromosome arms 1AS, 2BS and 7AS. QTL for 4 growth related traits taken together detected by different methods ranged from 37 to 40; nine QTL that were detected by single-locus as well as two-locus analyses were all M-QTL. Similarly, single-locus and two-locus QTL analyses for seven yield and yield contributing traits in two populations respectively allowed detection of 25 and 50 QTL by composite interval mapping (CIM), 16 and 25 QTL by multiple-trait composite interval mapping (MCIM) and 38 and 37 QTL by two-locus analyses. These studies should prove useful in QTL cloning and wheat improvement through marker aided selection. | PUSHPENDRA Kumar Gupta HARINDRA Singh Balyan PAWAN Laxminarayan Kulwal NEERAJ Kumar AJAY Kumar REYAZUL Rouf Mir AMITA Mohan JITENDRA Kumar | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，11： | 1 |
| 9 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications显示文摘 | Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 10 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications 显示文摘 | Ajay Kumar Gupta Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 11 | Synthesis and surface engineering of iron oxidenanoparticles for biomedical applications显示文摘 | Ajay Kumar Gupta Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 12 | Applications of the non - dominated sorting genetic algorithm (NSGA) in chemical reaction engineering 显示文摘 | Anjana D Nandasana Ajay Kumar Ray Santosh K Gupta | 2003 | International Journal of Chemical Reactor Engineering2003，，1： | 1 |
| 13 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications显示文摘 | Ajay Kumar Gupta Mona Gupta | 2004 | Biomaterials2004，，18： | 1 |
| 14 | Gene networks in hexaploid wheat: interacting quantitative trait loci for grain protein content显示文摘 | Pawan Kulwal Neeraj Kumar Ajay Kumar Raj Kumar Gupta Harindra Singh Balyan Pushpendra Kumar Gupta | 2005 | Functional & Integrative Genomics2005，，4： | 1 |
| 15 | Indian task force for celiac disease:Current status显示文摘There are limited data on celiac disease(CD) from India.The limited knowledge about CD in India might be attributed to several factors.The fi rst meeting of the Indian Task Force for Celiac Disease was held in the Asian Institute of Gastroenterology,Hyderabad,India in December 2008.The objectives of the meeting were to focus research on prevalence of CD in the wheat-eating Northern vs the rice-eating Southern Indian population,low-budget serological assays to study the underprivileged population,to involve other medical subspecialties in CD,to suggest proper legislation regarding wheat food labeling,and to organize affordable food substitutes for patients with celiac disease. | Rajesh Gupta Duvvuru Nageshwar Reddy Govind K Makharia Ajit Sood Balakrishnan S Ramakrishna Surender Kumar Yachha Babu Ram Thapa Rupa Banerjee Sekaran Anuradha Usha Dutta Amarender Singh Puri Ajay Kumar Jain Chris JJ Mulder Ajay Kumar Sesikeran Boindala | 2009 | World Journal of Gastroenterology2009，15，48： | 1 |
| 16 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications 显示文摘 | AJAY KUMAR GUPTA MONA GUPTA | 2005 | Biomaterials2005，26，18： | 1 |
| 17 | Clinico-etiological and EEG profile of neonatal seizures显示文摘 | Dr. Ajay Kumar Ashish Gupta Bibek Talukdar | 2007 | The Indian Journal of Pediatrics2007，，1： | 1 |
| 18 | 显示文摘 | Ajay Kumar Guptaa Mona Gupta | 2005 | Biomaterials2005，26，： | 1 |
| 19 | COVID-19 mortality and its risk factors:A single-center observational study显示文摘Objectives:To determine COVID-19 mortality and its risk factors in hospitalized patients at of a tertiary care center in north India.Methods:A retrospective observational study was conducted of patients who were hospitalized from May 2020 to January 2021.The in-hospital mortality was assessed,and demographic variables and comorbidities between COVID-19 deaths and survivors were compared.Results:A total of 24000 patients were admitted during the study period,among which 17000 had shown positive results of the RT-PCR test for COVID-19.The total mortality was 329 patients(1.37%),among which 232(70.52%)succumbed due to COVID-19,and 97(29.48%)died due to other illnesses.The mean age of the patients was(64.09依16.99)years.The mean age was significantly higher in COVID-19 related deaths[(67.63±13.78)years]as compared to that of the survivors[(60.52±19.5)years](P<0.001).Compared to COVID-19 survivors,there were more males(72.41%v.s.61.5%)and less females(27.59%v.s.38.5%)in COVID-19 related deaths(P=0.001).Comorbidities such as hypertension,diabetes mellitus,and chronic kidney disease showed a significant correlation with COVID-19 mortality with an adjusted odds ratio of 2.389(95%CI:1.465-2.982),3.891(95%CI:2.059-5.392),and 6.358(95%CI:5.675-10.564),respectively.Conclusions:Elderly males with comorbidities have higher risk for mortality related to COVID-19.Ongoing vaccination drive is rightfully prioritised to serve the high-risk category first. | Ajay Kumar Gupta Neena Katoch Rachna Gulati Vikas Kumar Sharmendra Singh Ketan Garg | 2021 | Journal of Acute Disease2021，10，6： | 0 |
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