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| 1 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 2 | Factors Affecting the Policy for Distributing Computing Resources 显示文摘 | Ahituv N S Neumann M Zviran | 1989 | Management Information System Quarterly1989，13，1： | 1 |
| 3 | The Effects of Time Pressure and Completeness of Information on Decision Makin g显示文摘 | Ahituv N Igbaria M Sella A | | 0，，： | 1 |
| 4 | A distal enhancer and an ultraconserved exon are derived from a novel retroposon显示文摘 | Bejerano G Lowe C B Ahituv N | 2006 | Nature2006，441，7089： | 1 |
| 5 | Measuring the power of information in organizations 显示文摘 | Ahituv N Carmi N | 2007 | Human Systems Management2007，26，4： | 1 |
| 6 | Off - farm Work and Capital Accumulation Decisions of Farmers Over the Life - cycle: the Role of Heterogeneity and State Dependence 显示文摘 | Avner Ahituv Ayal Kimhi | 2002 | Journal of Development Economics2002，68，2： | 1 |
| 7 | Building outsourcing relationships across the global community: The UPS-Motorola experience显示文摘 | Zviran M Ahituv N Armoni A | 2001 | Journal of Strategic Information Systems2001，10，： | 1 |
| 8 | MYO6, the human homologue of the gene responsible for deafness in Snelrs waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss显示文摘 | Melchionda S Ahituv N Bisceglia L | 2001 | Am J Hum Genet2001，69，3： | 1 |
| 9 | A systematic approach toward assessing the value of an information system显示文摘 | Ahituv N | 1980 | MIS Quarterly1980，4，4： | 1 |
| 10 | Off-farm Work and Capital Accumulation Decisions of Farmers over the Life-cycle: The Role of Heterogeneity and State Dependence 显示文摘 | Avner Ahituv Ayal Kimhi | 2002 | Journal of Development Economics2002，68，2： | 1 |
| 11 | Medical sequencing at the extremes of human body mass 显示文摘 | Ahituv N Kavaslar N Schackwitz W | 2007 | Am J Hum Genet2007，80，4： | 1 |
| 12 | In vivo enhancer analysis of human conserved non-coding sequences显示文摘 | Pennacchio LA Ahituv N Moses AM Prabhakar S Nobrega MA Shoukry M Minovitsky S Dubchak I Holt A Lewis KD Plajzer-Frick I Akiyama J De Val S Afzal V Black BL Couronne O Eisen MB Visel A Rubin EM | | 0，，7118： | 1 |
| 13 | Gain-of-function R225W mutation in human AMPKγ3 causing increased glycogen and decreased triglyceride in skeletal muscle 显示文摘 | Costford S R Kavaslar N Ahituv N | 2007 | PLoS ONE2007，2，9： | 1 |
| 14 | Measuring the power of information in organization显示文摘 | AHITUV N CARMI N | 2007 | Human Systems Management2007，26，： | 1 |
| 15 | Studies of TBX4 and chromosome 17q23.1q23.2: An uncommon cause of nonsyndromic clubfoot显示文摘 | W. Lu C.A. Bacino B.S. Richards C. Alvarez J.E. VanderMeer M. Vella N. Ahituv N. Sikka F.R. Dietz S.H. Blanton J.T. Hecht | 2012 | Am. J. Med. Genet2012，，7： | 1 |
| 16 | A distal enhancer and an ultraconserved exon are derived from a novel retroposon显示文摘 | Bejerano G Lowe CB Ahituv N King B Siepel A Salama SR Rubin EM Kent WJ Haussler D | | 0，，7089： | 1 |
| 17 | Measuring the power of information in organizations 显示文摘 | Ahituv N and Carmi N | 2007 | Human Systems Management2007，26，4： | 1 |
| 18 | Processing encrypted data显示文摘 | Niv Ahituv Yeheskel Lapid Seev Neumann | 1987 | Communications of the ACM1987，30，9： | 1 |
| 19 | Building Outsourcing Rela-tionship across the Global Community:the UPS-Motorola Experi-ence显示文摘 | Moshe Zviran Niv Ahituv | 2001 | The Journal of Strategic Information Systems2001，10，04： | 1 |
| 20 | Measuring the power of informa- tion in organization显示文摘 | Ahituv N Carmi N | 2007 | Human Systems Management2007，26，4： | 1 |
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