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| 1 | 温度限制串联相关神经网络及其在细菌辨识中的应用显示文摘蛋白质在微生物研究中可用作生物标记物, 故在生物技术中其表征工作很重要. 各种质谱技术已被用于细菌的表征[1~3]. 1994年, Cain等[4]首先报道了将色谱和基体辅助激光解离/电离飞行时间质谱(MALDI-TOF-MS)用于细菌的辨识. Holland等[5]采用高质量离子MALDI-TOF-MS对细菌全细胞进行辨识. 最近, Lay[6]对该技术的细菌辨识做了综述. MALDI-TOF-MS是目前对细菌全细胞分析的最佳手段. | 张卓勇 Aaron Urbas Peter de B Harrington Kent J.Voorhees Jon Rees | 2002 | 高等学校化学学报2002，23，4： | 4 |
| 2 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | Posterolateral Transfibular Approach to Tibial Plateau Fractures: Technique, Results, and Rationale显示文摘 | Lucian B Solomon Aaron W Stevenson Robert P V Baird Anthony P Pohl | 2010 | Journal of Orthopaedic Trauma2010，，8： | 2 |
| 5 | Plant FtsZ1 and FtsZ2 expressed in a eukaryotic host: GTPase activity and self-assembly显示文摘 | Aaron G S Carol B J Stanislav V et ol | 2010 | FEBS letters2010，584，1： | 1 |
| 6 | The application of GPS observations to equatorial aeronomy 显示文摘 | MENDILLO M LIN B S AARONS J | 2000 | Radio Science2000，35，3： | 1 |
| 7 | Enantioselective chronic toxicity of fipronil to Ceriodaphnia dubia显示文摘 | AARON WILSON W KONWICK B J GARRISON A W | 2008 | Arch Environ Contam Toxicol2008，54，1： | 1 |
| 8 | Inva- sivem eningococcal disease in adolescents and young adults 显示文摘 | Lee HH arriso Margaret A Pass Aaron B Mendelsohn | 2001 | The Journal of the American Medical Association2001，286，6： | 1 |
| 9 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 10 | Photochemically induced fluorescence investigation of a β-cyclodextrin: Azure a inclusion complex and determination of analytical Parameters 显示文摘 | MAAFI M LAASS B AARON J J | 1995 | J Incl Phenom Mol Recognit Chem1995，22，： | 1 |
| 11 | On the Growth Kineties of Grain Boundary Ferrite Allotriomorphs 显示文摘 | Atkinson C Aaron H B Kinsman K R | 1973 | Metall Trans1973，4，： | 1 |
| 12 | Growth of Grain Boundary Precipitates in Al-4% Cu By Interracial Diffusion 显示文摘 | Aaron H B Aaronson H I | 1968 | Acta Metall1968，16，6： | 1 |
| 13 | Distributed video coding显示文摘 | GIROD B AARON A M REBOLLO-MONEDERO D | 2005 | Proceeding of the IEEE2005，93，1： | 1 |
| 14 | Neurophysiology of spectrotemporal cue organization of spoken language in auditory memory显示文摘 | AARON C M JYOTI B BRADLEY D W | 2014 | Brain Lang2014，130，： | 1 |
| 15 | Polychlorinated biphenyl profiles in ringed seals (Pusa Hispida) reveal historical contamination by a military radar station in Labrador, Canada显示文摘 | Tanya M B Aaron T F Caren C H | 2014 | Environmental Toxicology and Chemistry2014，33，3： | 1 |
| 16 | Hypersonic boundary- layer trip development for Hyper-X 显示文摘 | Scott A B Aaron H A Authur D D | 2001 | Journal of Spacecraft and Rockets2001，38，6： | 1 |
| 17 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 18 | Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease显示文摘 | AARON S D ANGEL J B LUNAU M | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 19 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 20 | Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease显示文摘 | Aaron S D Angel J B Lunau M | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
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