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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system显示文摘Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill,an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5 cm thick red mud layer was removed from the flooded soil surface. The removed red mud and soil mixture(RMSM) was transferred into the reservoirs for storage. In this paper the application of RMSM is evaluated in a field study aiming at re-utilizing waste, decreasing cost of waste disposal and providing a value-added product. The purpose was to investigate the applicability of RMSM as surface layer component of landfill cover systems. The field study was carried out in two steps: in lysimeters and in field plots. The RMSM was mixed at ratios ranging between 0 and 50% w/w with low quality subsoil(LQS) originally used as surface layer of an interim landfill cover. The characteristics of the LQS + RMSM mixtures compared to the subsoil(LQS) and the RMSM were determined by physical–chemical, biological and ecotoxicological methods. The addition of RMSM to the subsoil(LQS) at up to 20% did not result any ecotoxic effect, but it increased the water holding capacity. In addition, the microbial substrate utilization became about triple of subsoil(LQS) after 10 months. According to our results the RMSM mixed into subsoil(LQS) at20% w/w dose may be applied as surface layer of landfill cover systems. | Eva Ujaczki Viktória Feigl Mónika Molnár Emese Vaszita Nikolett Uzinger Attila Erdélyi Katalin Gruiz | 2016 | Journal of Environmental Sciences2016，28，6： | 3 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 5 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 6 | Silicones on fibrous substrates: their mode of action显示文摘 | ATTILA B DIETER R ANDREAS M | 2001 | AATCC Review2001，1，1： | 1 |
| 7 | Effect of Ischemic Preconditioning on Rat Liver Microcirculation Monitored with Laser Doppler Flowmetry显示文摘 | Attila Szijártó Oszkár Hahn Gábor Lotz Zsuzsa Schaff Emilia Madarász Péter Károly Kupcsulik | 2006 | Journal of Surgical Research2006，，1： | 1 |
| 8 | TRP channels in the skin显示文摘 | Balázs I Tóth Attila Oláh Attila Gábor Sz?ll?si Tamás Bíró | 2014 | Br J Pharmacol2014，，10： | 1 |
| 9 | Transition of somatic plant cells to an embryogenic state显示文摘 | Attila Fehér Taras P. Pasternak Dénes Dudits | 2003 | Plant Cell Tissue and Organ Culture2003，，3： | 1 |
| 10 | Serum transferrin and ferritin in pubertal boys relations to body growth, pubertal stage, erythropoiesis,and iron deficiency显示文摘 | ATTILA R SIIMES M A | 1996 | Am J Clin Nutr1996，63，2： | 1 |
| 11 | HPV16 L1 and L2 DNA methylation predicts high‐grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology显示文摘 | Attila T Lorincz Adam R Brentnall Nata?a Vasiljevi? Dorota Scibior‐Bentkowska Alejandra Castanon Alison Fiander Ned Powell Amanda Tristram Jack Cuzick Peter Sasieni | 2013 | Int J Cancer2013，，3： | 1 |
| 12 | Yttrium Normalisation: a New Tool for Detection of Chromium Contamination in Soil Samples显示文摘 | József Prokisch Béla Kovács Attila J. Palencsár Ildikó Szegvári Zoltán Gy?ri | 2000 | Environmental Geochemistry and Health2000，，4： | 1 |
| 13 | Characterization of rapid PDMS casting technique utilizing molding forms fabricated by 3D rapid prototyping technology (RPT)显示文摘 | Attila Bonyár Hunor Sántha Máté Varga Balázs Ring András Vitéz Gábor Harsányi | 2014 | International Journal of Material Forming2014，，2： | 1 |
| 14 | Artificial fractal dimension obtained by using perimeter-area relationship on digitalized images显示文摘 | Attila R Imre | 2006 | Applied Mathematics and Computation2006，173，1： | 1 |
| 15 | Volatile Composition of Macedonian and Hungarian Wines Assessed by GC/MS显示文摘 | Violeta Ivanova Marina Stefova Borimir Vojnoski Traj?e Stafilov Ildiko Bíró Anita Bufa Attila Felinger Ferenc Kilár | 2013 | Food and Bioprocess Technology2013，，6： | 1 |
| 16 | Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission显示文摘 | Gergely Toldi Gabriella Bek? Gabriella Kádár Emília Mácsai László Kovács Barna Vásárhelyi Attila Balog | 2013 | Clinical Chemistry and Laboratory Medicine2013，，2： | 1 |
| 17 | Stimulation of endothelial nitric oxide production by homocyst(e)ine显示文摘 | Gilbert R Upchurch George N Welch Attila J Fabian Alessio Pigazzi John F Keaney Joseph Loscalzo | 1997 | Atherosclerosis1997，，2： | 1 |
| 18 | Artificial fractal dimension obtained by using perimeter–area relationship on digitalized images显示文摘 | Attila R Imre | 2006 | Applied Mathematics and Computation2006，173，： | 1 |
| 19 | Role of endoscopic clipping in the treatment of oesophagealperforations显示文摘With advances in endoscopic technologies,endoscopic clips have been used widely and successfully in the treatment of various types of oesophageal perforations,anastomosis leakages and fistulas. Our aim was to summarize the experience with two types of clips: The through-the-scope(TTS) clip and the over-the-scope clip(OTSC). We summarized the results of oesophageal perforation closure with endoscopic clips. We processed the data from 38 articles and 127 patients using PubM ed search. Based on evidence thus far,it can be stated that both clips can be used in the treatment of early(< 24 h),iatrogenic,spontaneous oesophageal perforations in the case of limited injury or contamination. TTS clips are efficacious in the treatment of 10 mm lesions,while bigger(< 20 mm) lesions can be treated successfully with OTSC clips,whose effectiveness is similar to that of surgical treatment. However,the clinical success rate is significantly lower in the case of fistulas and in the treatment of anastomosis insufficiency. Tough prospective randomized multicentre trials,which produce the largest amount of evidence,are still missing. Based on experience so far,endoscopic clips represent a possible therapeutic alternative to surgery in the treatment of oesophageal perforations under well-defined conditions. | György Lázár Attila Paszt Eszter Mán | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 1 |
| 20 | Effects of leaching from alkaline red mud on soil biota: modelling the conditions after the Hungarian red mud disaster显示文摘 | Márk Rékási Viktória Feigl Nikolett Uzinger Katalin Gruiz András Makó Attila Anton | 2013 | Chemistry and Ecology2013，，8： | 1 |
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